7 research outputs found
Ligand-enabled multiple absolute stereocontrol in metal-catalysed cycloaddition for construction of contiguous all-carbon quaternary stereocentres
No full textNi-Catalyzed Reductive Homocoupling of Unactivated Alkyl Bromides at Room Temperature and Its Synthetic Application
No full textRecent Developments in the Catalytic, Asymmetric Construction of Pyrroloindolines Bearing All-Carbon Quaternary Stereocenters
No full textCatalytic enantioselective synthesis of quaternary carbon stereocentres
No full textQuaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single stereoisomers of this important structural motif. Here we discuss the many catalytic enantioselective reactions developed during the past decade for the synthesis of single stereoisomers of such organic molecules. This progress now makes it possible to incorporate quaternary stereocentres selectively in many organic molecules that are useful in medicine, agriculture and potentially other areas such as flavouring, fragrances and materials
2.5 RadicalâPolar Crossover Reactions
No full textInternational audienceAbstract Radicalâpolar crossover reactions, that is, single-electron redox events allowing for the interconversion between radical and ionic intermediates, make it possible to connect radical and polar processes in the same synthetic transformation. Such a combination is the basis of much original synthetic methodology, which is particularly useful in the context of domino, tandem, or multicomponent reactions. This chapter comprehensively covers the field of radicalâpolar crossover reactions, with a primary emphasis on transformations wherein both the radical and polar processes provide synthetic elaboration
