Quantitative Estimate of CO2 Emission Reduction from Reuse of Automobile Parts in Japan

In general, reusing automobile parts reduces not only the cost of replacing the failed parts but also the environmental load of manufacturing new parts. However, these effects have not yet been quantified. The present study focuses on determining the emitted CO2 during production and quantitatively evaluating its reduction by the reuse of automobile parts. First, CO2 emissions are calculated during the reused parts production process at the factory site. Thirty-nine automobiles from 27 models prepared in Japan are examined to measure the amount of CO2 emitted in the production of new parts. Furthermore, the CO2 emission reduction effect for different automobile models is estimated through multiple regression analysis. The CO2 emissions are assumed to be the objective variable, whereas the explanatory variables are derived from the data provided in the automobile inspection certificates. The presented quantitative estimate of CO2 emission reduction owing to the exploitation of reused parts is expected to promote policies for further reducing CO2 emissions and arouse public awareness regarding the benefits of recycling automobile parts

Reverse pharmacological effect of loop diuretics and altered rBSC1 expression in rats with lithium nephropathy

Reverse pharmacological effect of loop diuretics and altered rBSC1 expression in rats with lithium nephropathy.BackgroundRenal urinary concentration is associated with enhanced expression of rBSC1, a rat sodium cotransporter, in the thick ascending limb of Henle. Increased expression of rBSC1 was reported recently in nephrogenic diabetes insipidus induced by lithium chloride (Li nephropathy). However, the pathophysiological implication of altered rBSC1 expression has not yet been investigated.MethodsLi nephropathy was induced in rats by an oral administration of 40 mmol lithium/kg dry food. In rats with reduced urinary osmolality to less than 300 mOsm/kg H2O, we examined the expression of rBSC1 mRNA and protein, plasma arginine vasopressin (AVP) and RNA expression of kidney-specific water channel, aquaporin-2 (AQP2), of collecting ducts. Rats with Li nephropathy were treated with furosemide (3 mg/kg body weight), which blocks the activity of rBSC1, and changes in urine concentration, plasma AVP, medullary accumulation of Li ions, and apical AQP2 expression were determined.ResultsRats with Li nephropathy showed increased rBSC1 RNA and protein expression and reduced AQP2 RNA. In these rats, furosemide, which induces dilution of urine and polyuria in normal rats, resulted in a progressive and significant rise in urine osmolality from 167 ± 11 (mean ± SD) at baseline to 450 ± 45 mOsm/kg H2O at three hours after administration, and significant oliguria. In the same rats, plasma AVP decreased significantly from 5.7 to 3.0 pg/mL. In addition, recovery of apical AQP2 expression was noted in a proportion of epithelial cells of the collecting ducts. Although Li+ in the renal medulla was slightly lower in rats with Li nephropathy treated with furosemide, statistical significance was not achieved.ConclusionsOur results suggest that dehydration or high plasma AVP results in an enhanced rBSC1 expression in Li nephropathy, and that rBSC1 expression is closely associated with the adverse effects of Li ions on collecting duct function

Environmental Load Evaluation of Reuse Parts for Automobiles

Abstract Reuse parts are parts removed from scrap automobiles that can be still used. In general, reuse parts reduce not only the cost for replacement of failed parts but also the environmental load. This study quantitatively evaluates environmental loads, such as the amount of CO2 emission during the production of brand new parts, in order to quantify the beneficial effect of the reuse parts. The amount of CO2 emission can be calculated from the power consumption and operating time of each tool and machine employed. Reuse parts generate 0.62 kg of CO2 per automobile when produced, which corresponds to 1,212 kg per year. However, the amount of CO2 emitted from scrapping automobiles without producing new replacement parts is 3,063 kg per year. Therefore, the production of replacement parts emits three times less CO2 than scrapping

Partial and Total Electronic Stopping Cross Sections of Atoms for a Singly Charged Helium Ion : Part II

Partial and total electronic stopping cross sections of atoms with Z ( 55 leq Z leq 92 ) for a He^+ ion are tabulated as the second part of NIFS-DATA-11(1991) on the basis of the wave-packet theory [Phys.Rev. A40,2188(1989); Phys.Stat.Sol. (B)156,49(1989)]

Immunochemoradiotherapy for Patients with Oral Squamous Cell Carcinoma: Augmentation of OK-432-Induced Helper T Cell 1 Response by 5-FU and X-ray Irradiation

Eighty-one patients with oral squamous cell carcinoma (OSCC) received oral fluoropyrimidine UFT and radiotherapy (RT) with or without an immunotherapeutic agent OK-432. Both overall survival and progression-free survival of patients who received RT + UFT + OK-432 were significantly longer than those of patients who received RT + UFT (P = .0075 and P = .0175, respectively). Clinical response was also more favorable in RT + UFT + OK-432 group than in RT + UFT group (P = .0066). Next, in vitro experiments were conducted to examine the effect of 5-fluorouracil (5-FU) and X-ray irradiation in OK-432-induced immunity. Human peripheral blood mononuclear cells stimulated with OK-432 produced helper T cell 1 (Th1)-type cytokines as well as interleukin-10 (IL-10) and transforming growth factor-β (TGF-β), which are produced by Th2 and regulatory T cells (Tregs), respectively, and are inhibitory in antitumor immunity. OK-432-induced IL-10 and TGF-β but not Th1 cytokines were significantly inhibited by 5-FU and/or X-ray. 5-FU and X-ray also inhibited the expression of mRNAs for GATA-3 and Foxp3, which are transcription factors for Th2 and Tregs, respectively, but not for T-bet, a transcription factor for Th1. In addition, 5-FU and X-ray decreased the expression of mRNAs for suppressor of cytokine signaling 1 (SOCS1) and SOCS3. Antisense oligonucleotides for SOCS1 and SOCS3 markedly reduced OK-432-induced IL-10 and TGF-β. This is the first report clearly demonstrating that OK-432-based immunotherapy significantly enhanced the therapeutic effects of chemoradiotherapy in patients with OSCC as well as elucidating the mechanism of the synergistic effect of immunochemoradiotherapy in which 5-FU and radiation enhanced OK-432-induced Th1 response mediated by the inhibition of SOCS1 and SOCS3 gene expression