U.S. Dairy Farmer Perceptions and Actions Around Climate Change

In the spring of 2023, a national survey of United States dairy farmers was conducted to understand how producers are thinking about and approaching changing climate and weather, with a focus on animal, manure management, and land use strategies that can help reduce greenhouse gas emissions.. A total of 920 dairy farmers, approximately 1 in every 29, responded to this survey. This report summarizes the findings of this survey

Effect of Ad Libitum vs. Limit Feeding Program at Receiving on Morbidity and Performance of Feedlot Calves

A two-phase study was conducted to determine the effects of two different feed delivery strategies during the receiving period of feedlot calves. Calves were fed either by limit-feeding at approximately 75% of ad libitum, or ad libitum feed offerings for the 30-d receiving period to determine effects on health and performance. During the receiving period, average daily gain and total weight gained was increased for the ad libitum treatment. No differences between ad libitum and limit-fed treatment groups were observed in either feed to gain or morbidity rates. During the second phase of the trial, a subset of calves was followed through finishing to observe the effect of the receiving strategies on the finishing period performance. At slaughter, no significant differences were observed between calves that were received on a limit fed diet or fed ad libitu

Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review

Parkinson’s disease (PD) is a prevalent neurodegenerative disease in which treatment often includes an exercise regimen. Exercise is neuroprotective in animal models of PD, and, more recently, human clinical studies have verified exercise’s disease-modifying effect. Aerobic exercise and resistance training improve many of PD’s motor and non-motor symptoms, while neuromotor therapy and stretching/flexibility exercises positively contribute to the quality of life in people with PD. Therefore, understanding the role of exercise in managing this complex disorder is crucial. Exerkines are bioactive substances that are synthesized and released during exercise and have been implicated in several positive health outcomes, including neuroprotection. Exerkines protect neuronal cells in vitro and rodent PD models in vivo. Aerobic exercise and resistance training both increase exerkine levels in the blood, suggesting a role for exerkines in the neuroprotective theory. Many exerkines demonstrate the potential for protecting the brain against pathological missteps caused by PD. Every person (people) with Parkinson’s (PwP) needs a comprehensive exercise plan tailored to their unique needs and abilities. Here, we provide an exercise template to help PwP understand the importance of exercise for treating PD, describe barriers confronting many PwP in their attempt to exercise, provide suggestions for overcoming these barriers, and explore the role of exerkines in managing PD. In conclusion, exercise and exerkines together create a powerful neuroprotective system that should contribute to slowing the chronic progression of PD

Strategies for DDGS Supplementation Frequency to Frazing Yearling Streers

Infrequent supplementation saves labor and may reduce animal performance, but recent research with reduced fat distillers grains has provided inconsistent results. This experiment evaluated the effects of daily and three times a week supplementation of dried distillers grains on yearling steer performance grazing smooth bromegrass pastures from May to August. Daily supplemented steers received 5.6 pounds of dry matter per steer of dried distillers grains with solubles 7 days/week. The three times a week supplemented steers received 13.0 pounds of dry matter per steer of dried distillers grains with solubles three days/week (Monday, Wednesday, Friday). A control treatment received no supplementation. Providing distillers grains supplement increased gain by 0.89 pounds per day compared to non-supplemented cattle. Daily supplementation of dried distillers grains increases gain by 0.31 pounds per day compared to three times a week supplementation and a non-supplemented control. Supplementing distillers gains three times per week may reduce ADG by 10% compared to daily supplementation

Evaluation of Encapsulated \u3ci\u3eMegasphaera Elsdenii\u3c/i\u3e in an Accelerated Beef Step-Up Program and an Acidosis Challenge Event

A 100-day metabolism study with 40 ruminally cannulated steers, individually fed, was conducted to determine the efects of daily feeding of encapsulated Megasphaera elsdenii along with a one-time dose of Lactipro NXT on dry matter intake, rumen organic acid concentration, lactate disappearance and native and specific strains of Megasphaera elsdenii concentration following an acidosis challenge. Steers fed Megasphaera elsdenii daily had greater intake after an acidosis event. Cattle fed daily Megasphaera elsdenii also had a faster rate of lactic acid disappearance after an acidosis event. Feeding Megasphaeara elsdenii daily may result in a faster recovery time, after an acidosis event, comapred to a one-time drench of Megaspharea elsdenii

Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model: a central role for gene-environment interactions

There are no current treatments for autism, despite its high prevalence. Deletions of chromosome 16p11.2 dramatically increase risk for autism, suggesting that mice with an equivalent genetic rearrangement may offer a valuable model for the testing of novel classes of therapeutic drug. 16p11.2 deletion (16p11.2 DEL) mice and wild-type controls were assessed using an ethological approach, with 24 h monitoring of activity and social interaction of groups of mice in a home-cage environment. The ability of the excitation/inhibition modulator N-acetyl cysteine (NAC) and the 5-HT1B/1D/1F receptor agonist eletriptan to normalise the behavioural deficits observed was tested. 16p11.2 DEL mice exhibited largely normal behaviours, but, following the stress of an injection, showed hyperlocomotion, reduced sociability, and a strong anxiolytic phenotype. The hyperactivity and reduced sociability, but not the suppressed anxiety, were effectively attenuated by both NAC and eletriptan. The data suggest that 16p11.2 DEL mice show an autism-relevant phenotype that becomes overt after an acute stressor, emphasising the importance of gene-environmental interactions in phenotypic analysis. Further, they add to an emerging view that NAC, or 5-HT1B/1D/1F receptor agonist treatment, may be a promising strategy for further investigation as a future treatment

Evaluation of Gas Emissions from Cattle on Different Diet Adaptation Strategies Using Either Forage or RAMP

A 173-day finishing experiment was conducted to evaluate the effects of feeding RAMP (Cargill Corn Milling, Blair, NE) during diet adaptation compared to a traditional forage adaptation program on methane and carbon dioxide emissions, animal performance and carcass traits in beef steers. Cattle were monitored using a calorimetry emission barn to quantify production of methane and carbon dioxide during step 1 of grain adaptation and at two subsequent times while fed a common finishing diet. Feeding RAMP reduced methane by 12% during the initial diet (step 1) compared to a traditional diet that contained 43% forage. When cattle were fed the same finishing diet, there was a 9% reduction in methane due to carryover effects from feeding RAMP during grain adaptation. Cattle fed RAMP tended to increase hot carcass weight by 13 pounds. These data suggest feeding RAMP during grain adaptation instead of forage could be a strategy to reduce methane emissions. The performance benefits from RAMP would further decrease methane production per pound of gain

Genetic Determinants of Radiographic Knee Osteoarthritis in African Americans

OBJECTIVE: The etiology of knee osteoarthritis (OA), the most common form of arthritis, is complex and may differ by race or ethnicity. In recent years, genetic studies have identified many genetic variants associated with OA, but nearly all the studies were conducted in European whites and Asian Americans. Few studies have focused on the genetics of knee OA in African Americans. METHODS: We performed a genome-wide association study of radiographic knee OA in 1217 African Americans from 2 North American cohort studies: 590 subjects from the Johnston County Osteoarthritis Project and 627 subjects from the Osteoarthritis Initiative. Analyses were conducted in each cohort separately and combined in an inverse variance fixed effects metaanalysis, which were then included in pathway analyses. We additionally tested 12 single-nucleotide polymorphisms robustly associated with OA in European white populations for association in African Americans. RESULTS: We identified a genome-wide significant variant in LINC01006 (minor allele frequency 12%; p = 4.11 — 10-9) that is less common in European white populations (minor allele frequency < 3%). Five other independent loci reached suggestive significance (p < 1 — 10-6). In pathway analyses, dorsal/ventral neural tube patterning and iron ion transport pathways were significantly associated with knee OA in African Americans (false discovery rate < 0.05). We found no evidence that previously reported OA susceptibility variants in European whites were associated with knee OA in African Americans. CONCLUSION: These results highlight differences in the genetic architecture of knee OA between African American and European whites. This finding underscores the need to include more diverse populations in OA genetics studies