497 research outputs found
Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia
Heavy drinkers are at risk for a spectrum of histologic alcohol-related liver injury: steatosis, alcoholic steatohepatitis (ASH), alcohol-related fibrosis, and cirrhosis. Alcoholic hepatitis (AH), the clinical entity associated with severe ASH, has high short-term mortality. The standard-of-care therapy, prednisolone, has limited efficacy and many side effects; no other treatment has consistently shown survival benefit. The National Institute on Alcohol Abuse and Alcoholism (NIAAA)-funded Alcoholic Hepatitis Consortia carry out translational research on pathophysiologic mechanisms, genetic and environmental risk factors, phase II clinical trials, and development of biomarkers. The consortia members were convened by the National Institutes of Health to address diagnostic criteria and practical issues related to clinical AH research, and to develop a set of common data elements to harmonize ongoing and future trials. This was accomplished through 3 face-to-face meetings of the investigators and representatives of the National Institutes of Health, and subsequent electronic communications over the course of 6 months. Evidence for the recommendations was based on published trials and observational data from several of the consortia members. A draft manuscript was iteratively reviewed by members of the consortia. The goal was to reach agreements on recommendations and definitions that could facilitate trial design, and simultaneously be tested by research groups pooling their data. The recommendations made here are specifically directed to achieve better uniformity in clinical trials, rather than serving as clinical practice guidelines
Correlated Strength in Nuclear Spectral Function
We have carried out an (e,e'p) experiment at high momentum transfer and in
parallel kinematics to measure the strength of the nuclear spectral function
S(k,E) at high nucleon momenta k and large removal energies E. This strength is
related to the presence of short-range and tensor correlations, and was known
hitherto only indirectly and with considerable uncertainty from the lack of
strength in the independent-particle region. This experiment confirms by direct
measurement the correlated strength predicted by theory.Comment: 4 pages, 2 figures, accepted by Phys. Rev. Let
Qweak: A Precision Measurement of the Proton's Weak Charge
The Qweak experiment at Jefferson Lab aims to make a 4% measurement of the
parity-violating asymmetry in elastic scattering at very low of a
longitudinally polarized electron beam on a proton target. The experiment will
measure the weak charge of the proton, and thus the weak mixing angle at low
energy scale, providing a precision test of the Standard Model. Since the value
of the weak mixing angle is approximately 1/4, the weak charge of the proton
is suppressed in the Standard Model, making it
especially sensitive to the value of the mixing angle and also to possible new
physics. The experiment is approved to run at JLab, and the construction plan
calls for the hardware to be ready to install in Hall C in 2007. The
theoretical context of the experiment and the status of its design are
discussed.Comment: 5 pages, 2 figures, LaTeX2e, to be published in CIPANP 2003
proceeding
How Should Addiction-Related Research at the National Institutes of Health be Reorganized?
The decades-old debate about the optimum organizational structure of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and National Institute on Drug Abuse (NIDA) has reached a crescendo with the recent deliberations of the Scientific Management Review Board, which, despite the lack of a crisis, proposed a structural reorganization that would dissolve the two institutes and create a new institute for substance use, abuse, and addiction, in hope of new scientific and public health advances (Collins, 2010). For a new institute to succeed, a multitude of potential challenges need to be negotiated effectivel
Inclusive Electron-Nucleus Scattering at Large Momentum Transfer
Inclusive electron scattering is measured with 4.045 GeV incident beam energy
from C, Fe and Au targets. The measured energy transfers and angles correspond
to a kinematic range for Bjorken and momentum transfers from . When analyzed in terms of the y-scaling function the data show
for the first time an approach to scaling for values of the initial nucleon
momenta significantly greater than the nuclear matter Fermi-momentum (i.e. GeV/c).Comment: 5 pages TEX, 5 Postscript figures also available at
http://www.krl.caltech.edu/preprints/OAP.htm
Cross Section Measurement of Charged Pion Photoproduction from Hydrogen and Deuterium
We have measured the differential cross section for the gamma n --> pi- p and
gamma p --> pi+ n reactions at center of mass angle of 90 degree in the photon
energy range from 1.1 to 5.5 GeV at Jefferson Lab (JLab). The data at photon
energies greater than 3.3 GeV exhibit a global scaling behavior for both pi-
and pi+ photoproduction, consistent with the constituent counting rule and the
existing pi+ photoproduction data. Possible oscillations around the scaling
value are suggested by these new data The data show enhancement in the scaled
cross section at a center-of-mass energy near 2.2 GeV. The cross section ratio
of exclusive pi- to pi+ photoproduction at high energy is consistent with the
prediction based on one-hard-gluon-exchange diagrams
Determination of the pion charge form factor for Q^2=0.60-1.60 GeV^2
The data analysis for the reaction H(e,e' pi^+)n, which was used to determine
values for the charged pion form factor Fpi for values of Q^2=0.6-1.6 GeV^2,
has been repeated with careful inspection of all steps and special attention to
systematic uncertainties. Also the method used to extract Fpi from the measured
longitudinal cross section was critically reconsidered. Final values for the
separated longitudinal and transverse cross sections and the extracted values
of Fpi are presented.Comment: 11 pages, 6 figure
Cross Section Measurements of Charged Pion Photoproduction in Hydrogen and Deuterium from 1.1 to 5.5 GeV
The differential cross section for the gamma +n --> pi- + p and the gamma + p
--> pi+ n processes were measured at Jefferson Lab. The photon energies ranged
from 1.1 to 5.5 GeV, corresponding to center-of-mass energies from 1.7 to 3.4
GeV. The pion center-of-mass angles varied from 50 degree to 110 degree. The
pi- and pi+ photoproduction data both exhibit a global scaling behavior at high
energies and high transverse momenta, consistent with the constituent counting
rule prediction and the existing pi+ data. The data suggest possible
substructure of the scaling behavior, which might be oscillations around the
scaling value. The data show an enhancement in the scaled cross section at
center-of-mass energy near 2.2 GeV. The differential cross section ratios at
high energies and high transverse momenta can be described by calculations
based on one-hard-gluon-exchange diagrams.Comment: 18 pages, 19 figure
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