Gamma-400 Science Objectives Built on the Current HE Gamma-Ray and CR Results

The main scientific interest of the Russian Gamma-400 team: Observe gamma-rays above approximately 50 GeV with excellent energy and angular resolution with the goals of: (1) Studying the fine spectral structure of the isotropic high-energy gamma-radiation, (2) Attempting to identify the many still-unidentified Fermi-LAT gamma-ray sources. Gamma-400 will likely be the only space-based gamma-ray observatory operating at the end of the decade. In our proposed Gamma-400-LE version, it will substantially improve upon the capabilities of Fermi LAT and AGILE in both LE and HE energy range. Measuring gamma-rays from approx 20 MeV to approx 1 TeV for at least 7 years, Gamma-400-LE will address the topics of dark matter, cosmic ray origin and propagation, neutron stars, flaring pulsars, black holes, AGNs, GRBs, and actively participate in multiwavelength campaigns

Mars nightside electrons over strong crustal fields

We investigated 7 years worth of data from the electron reflectometer and magnetometer aboard Mars Global Surveyor to quantify the deposition of photoelectron and solar wind electron populations on the nightside of Mars, over the strong crustal field region located in the southern hemisphere. Just under 600,000 observations, each including energy and pitch angle distributions, were examined. For solar zenith angles (SZA) less than 110°, photoelectrons have the highest occurrence rate; beyond that, plasma voids occur most often. In addition, for SZA >110°, energy deposition of electrons mainly occurs on vertical field lines with median pitch angle averaged energy flux values on the order of 107–108 eV cm−2 s−1. The fraction of downward flux that is deposited at a given location was typically low (16% or smaller), implying that the majority of precipitated electrons are magnetically reflected or scattered back out. The average energy of the deposited electrons is found to be 20–30 eV, comparable to typical energies of photoelectrons and unaccelerated solar wind electrons. Median electron flux values, from near‐vertical magnetic field lines past solar zenith angle of 110°, calculated in this study produced a total electron content of 4.2 × 1014 m−2 and a corresponding peak density of 4.2 × 103 cm−3.Key PointsElectron populations on the nightside of Mars are exploredOccurrence rates and energy deposition values are calculatedMedian precipitating flux yields a peak ne of 4.2 × 103 cm−3Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137525/1/jgra52560.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137525/2/jgra52560_am.pd

Primjena proizvoda dobivenog fermentacijom, koji sadrži lipaze iz Rhizopus microsporus, u hidrolizi otpadnih voda mliječne industrije s velikim udjelom masnoća

The filamentous fungus Rhizopus microsporus CPQBA 312-07 DRM was grown in solid-state cultivation and the fermented solid produced was used to hydrolyze triacylglycerols in a high-fat dairy wastewater. For the solid-state cultivation, a mixture of sunflower seed meal and sugarcane bagasse (1:3 by mass on dry basis) was selected. After 18 h of culture, the fermented product had an activity, measured titrimetrically against triolein, of 26 U per gram of dry solids. This substrate mixture does not suffer from compaction and therefore can be used in large scale solid-state cultivation bioreactors. When used to pretreat a high-fat dairy wastewater, with an oil and grease level above 1300 mg/L, the fermented solid reduced the oil and grease level to below 300 mg/L after 72 h at 35 °C. Further work is required to improve the production of lipolytic activity in the solid-state cultivation step and to find the optimum pretreatment time in the wastewater pretreatment step.Uzgojem filamentozne plijesni Rhizopus microsporus CPQBA 312-07 DRM na čvrstoj podlozi dobiven je fermentirani proizvod koji se može upotrijebiti za hidrolizu triacilglicerola iz otpadnih voda mliječne industrije s velikim udjelom masnoća. Kao podloga za uzgoj upotrijebljena je smjesa suncokretove sačme i otpadaka šećerne trske u omjeru od 1:3, na bazi suhe tvari. Nakon 18 sati uzgoja dobiveni je proizvod imao aktivnost od 26 U/g suhe tvari, mjerenu titracijom pomoću trioleina. Utvrđeno je da se podloga može koristiti u bioreaktorima većeg volumena, a da dobiveni proizvod smanjuje udio masti i ulja u otpadnim vodama mliječne industrije s velikim udjelom masnoća (preko 1300 mg/L) čak za 300 mg/L nakon 72 sata fermentacije pri 35 °C. Postupak treba podrobnije ispitati kako bi se postigla veća lipolitička aktivnost i utvrdilo optimalno vrijeme prethodne obrade otpadnih voda

The effects of graded levels of calorie restriction : IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction

We would like to acknowledge the BSU staff for their invaluable help with caring for the animals. The work was supported by the UK Biotechnology and Biological Sciences Research Council BBSRC (BB/G009953/1 and BB/J020028/1).Peer reviewedPublisher PD

Current Techniques for the Cultivation of Ganoderma lucidum for the Production of Biomass, Ganoderic Acid and Polysaccharides

Ganoderma lucidum is a medicinal mushroom that has been used in the Orient for more than 2000 years. Due to the long time required for basidiocarp formation, attention has recently been given to the use of submerged fermentation for the production of mycelial biomass and its bioactive components, such as polysaccharides and ganoderic acids. We review the current state of knowledge about the cultivation of G. lucidum by modern fermentation techniques, focussing on the effects of fermentation conditions and how knowledge of these effects has been used to develop strategies for improving the production of biomass, polysaccharides and ganoderic acid. We also outline the methods that have been used for biomass and product recovery and point out potential problems involved in these steps. Studies to date have been almost entirely limited to laboratory scale and much more understanding of the physiology of G. lucidum and its relationship with growth morphology will be necessary before it will be possible to develop economical large scale processes

Microvascular resistance predicts myocardial salvage and infarct characteristics in ST-elevation myocardial infarction

<b>Background:</b> The pathophysiology of myocardial injury and repair in patients with ST‐elevation myocardial infarction is incompletely understood. We investigated the relationships among culprit artery microvascular resistance, myocardial salvage, and ventricular function.<p></p> <b>Methods and Results:</b> The index of microvascular resistance (IMR) was measured by means of a pressure‐ and temperature‐sensitive coronary guidewire in 108 patients with ST‐elevation myocardial infarction (83% male) at the end of primary percutaneous coronary intervention. Paired cardiac MRI (cardiac magnetic resonance) scans were performed early (2 days; n=108) and late (3 months; n=96) after myocardial infarction. T2‐weighted‐ and late gadolinium–enhanced cardiac magnetic resonance delineated the ischemic area at risk and infarct size, respectively. Myocardial salvage was calculated by subtracting infarct size from area at risk. Univariable and multivariable models were constructed to determine the impact of IMR on cardiac magnetic resonance–derived surrogate outcomes. The median (interquartile range) IMR was 28 (17–42) mm Hg/s. The median (interquartile range) area at risk was 32% (24%–41%) of left ventricular mass, and the myocardial salvage index was 21% (11%–43%). IMR was a significant multivariable predictor of early myocardial salvage, with a multiplicative effect of 0.87 (95% confidence interval 0.82 to 0.92) per 20% increase in IMR; P<0.001. In patients with anterior myocardial infarction, IMR was a multivariable predictor of early and late myocardial salvage, with multiplicative effects of 0.82 (95% confidence interval 0.75 to 0.90; P<0.001) and 0.92 (95% confidence interval 0.88 to 0.96; P<0.001), respectively. IMR also predicted the presence and extent of microvascular obstruction and myocardial hemorrhage.<p></p> <b>Conclusion:</b> Microvascular resistance measured during primary percutaneous coronary intervention significantly predicts myocardial salvage, infarct characteristics, and left ventricular ejection fraction in patients with ST‐elevation myocardial infarction.<p></p&gt

Meniscal Repair in Pediatric Populations: A Systematic Review of Outcomes

Background: Loss of meniscal tissue in the pediatric population can have long-term consequences on joint health, highlighting the importance of meniscal preservation in this group. Purpose: To systematically review reported knee outcome measures and complication rates after repair of meniscal tears in children and adolescents. Study Design: Systematic review; Level of evidence, 4. Methods: A review of the literature regarding the existing evidence for pediatric meniscal tear outcomes was performed through use of the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, PubMed (1980-present), and MEDLINE (1980-present). Included were articles in English that reported the outcomes of meniscal tears in the pediatric population (\u3c18 years old) with a follow-up of more than 12 months. Clinical outcome scores were reviewed. Results: A total of 1003 total studies were initially retrieved, with 8 meeting the inclusion criteria. The review included 287 patients (165 male, 122 female), mean age 15.1 years (range, 4-18 years), with 301 meniscal tears (reported: 134 medial, 127 lateral, and 32 both medial and lateral, 8 location unspecified). Concomitant anterior cruciate ligament reconstruction was performed in 52% (158/ 301) of meniscal repairs. The average reported postoperative Lysholm scores ranged from 85.4 to 96.3, and the average reported postoperative Tegner activity scores ranged from 6.2 to 8. Conclusion: Arthroscopic repair of a meniscal tear in the pediatric and adolescent population is an effective treatment option that has a low failure rate, enhances postoperative clinical outcomes, and preserves meniscal tissues