DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR THE DETERMINATION OF VALSARTAN

Objective: A stability indicating RP-HPLC method was developed and validated for the determination of Valsartan using Telmisartan (10 µg/ml) as the internal standard.Methods: In this procedure Phenomenex ODS C-18(250×4.6 mm, packed with 5 micron) column was used with a new mobile phase consisting of methanol: acetonitrile: water (70:15:15 v/v) and the pH was adjusted to 3 by 0.1% glacial acetic acid with a flow rate of 1 ml/min. The eluents were monitored at 249 nm. Valsartan was subjected to stress conditions including hydrolytic degradation in acidic, basic and neutral conditions, oxidation, photolytic, UV degradation and thermal degradation.Results: Linearity was obtained in the concentration range of 10-90 µg/ml (R2 =0.999) and with a regression equation y=0.074x+0.005. The LOD and LOQ values were 0.261 and 0.791 µg/ml respectively. The drug had shown promising degradation in the acidic, basic, neutral, thermal and oxidative stress conditions.Conclusion: The method was validated for accuracy, precision, linearity, specificity and robustness and revealed that it is specific, accurate, rapid, precise, reliable and reproducible enough to analyze commercial dosage forms as per ICH guidelines

Manufacture of the Futuristic Castable Type of Screening Smoke Composition

The present trend abroad is to replace conventional smoke compositions with castable type of smoke compositions because of superior performance of the latter over the former. The technology of castable screening smokes has been recently developed for the first time in India by the Explosives Research & Development Laboratory, Pune. This paper discusses the various advantages in large scale manufacture of castable type of screening smoke composition. A comparison is also made with the conventional method of manufacture of screening smoke composition currently followed

Analysis of Connecting Rod for Static Stress and Deformation for Different Materials

In the ever-evolving field of automotive engineering, the connecting rod assumes a pivotal role in the seamless transformation of reciprocating piston motion into the rotary motion that propels an engine's crankshaft. Traditionally crafted from carbon steel, recent strides in materials science have unveiled the potential of aluminium alloys as a compelling alternative. These alloys, lauded for their lightweight attributes and remarkable impact resistance, particularly excel in the demanding realm of high-speed motorcycle engines.Our investigation meticulously assesses crucial parameters including von Mises stress, Equivalent Elastic Strain and total Deformation

Efficient use of Magnetite in Coal Beneficiation Plants for Heavy Media Separation - A case study

Coal is a major commercial source of energy as a solid fuel for steel plants. The beneficiation of run of mine coal is mostly done by gravity separation using heavy media. Magnetite is the most widely used material for heavy media because of its higher stability in suspension, higher specific gravity, lower viscosity and easy avai-lability.Worldwide, almost 60% of total coal beneficiation is carried out by heavy media process. In India in 80% cases the heavy media used is magnetite. The paper esse-ntially deals with the magnetite stability factors, its preparation and recovery processes, its operational utilization and the existing systems in some Indian coal washing plants. A case study to operating system has been made with a view to identifying the major demerits and difficulties existing therein. Some remedial measures as applicable under Indian conditions have also beensuggested

Current-Induced Spin Polarization in Gallium Nitride

Electrically generated spin polarization is probed directly in bulk GaN using Kerr rotation spectroscopy. A series of n-type GaN epilayers are grown in the wurtzite phase both by molecular beam epitaxy (MBE) and metalorganic chemical vapor deposition (MOCVD) with a variety of doping densities chosen to broadly modulate the transverse spin lifetime, T2*. The spin polarization is characterized as a function of electrical excitation energy over a range of temperatures. Despite weak spin-orbit interactions in GaN, a current-induced spin polarization (CISP) is observed in the material at temperatures of up to 200 K.Comment: 16 pages, 3 figure

On Indexed Absolute Matrix Summability of an Infinite Series

Some results have been established on absolute index Riesz summability factor of an infinite series. Furthermore, these kind of results can be extended by taking other parameters and an absolute index matrix summability factor of an infinite series or some weaker conditions. In the present paper a new result on generalized absolute index matrix summability factor of an infinite series has been established