Mini-review: Wild laughs: Ontogenesis and phylogenesis of humour

This mini-review discusses the existing evidence on various forms of humour and humour-like behaviour in non-human animals, combining ontogenetic and phylogenetic perspectives. The first section describes humour-like behaviours, from the simplest to the most complex form (from laughing, tickling, joking, and chasing to ToM humour). In the second section, we propose the SPeCies (Social, Physiological, and Cognitive) Perspective, which frames the various types of humour based on Social motivation, Physiological state, and Cognitive skills. Finally, in the third section, we discuss future directions for further development

Impact of an irreversible β-galactosylceramidase inhibitor on the lipid profile of zebrafish embryos

Krabbe disease is a sphingolipidosis characterized by the genetic deficiency of the acid hydrolase beta-galactosylceramidase (GALC). Most of the studies concerning the biological role of GALC performed on Krabbe patients and Galc-deficient twitcher mice (an authentic animal model of the disease) indicate that the pathogenesis of this disorder is the consequence of the accumulation of the neurotoxic GALC substrate beta-galactosylsphingosine (psychosine), ignoring the possibility that this enzyme may exert a wider biological impact. Indeed, limited information is available about the effect of GALC downregulation on the cell lipidome in adult and developing organisms. The teleost zebrafish (Danio rerio) has emerged as a useful platform to model human genetic diseases, including sphingolipidoses, and two GALC co-orthologs have been identified in zebrafish (galca and galcb). Here, we investigated the effect of the competitive and irreversible GALC inhibitor beta-galactosecyclophellitol (GCP) on the lipid profile of zebrafish embryos. Molecular modelling indicates that GCP can be sequestered in the catalytic site of the enzyme and covalently binds human GALC, and the zebrafish Galca and Galcb proteins in a similar manner. Accordingly, GCP inhibits the beta-galactosylceramide hydrolase activity of zebrafish in vitro and in vivo, leading to significant alterations of the lipidome of zebrafish embryos. These results indicate that the lack of GALC activity deeply affects the lipidome during the early stages of embryonic development, and thereby provide insights into the pathogenesis of Krabbe disease

The key role of the right posterior fusiform gyrus in music reading: an electrical neuroimaging study on 90 readers

IntroductionIn this study, we employed a combined electromagnetic recording technique, i.e., electroencephalogram (EEG)/event-related potentials (ERPs) plus standardized weighted low-resolution electromagnetic tomography (swLORETA), to investigate the neural mechanism subserving the orthographic processing of symbols in language and music. While much is known about word processing, the current literature remains inconclusive regarding music reading, as its mechanisms appear to be left lateralized in some cases (as suggested by music-alexia clinical case reports) and either right-sided or bilateral in others, depending on the study and the methodology used.MethodsIn this study, 90 right-handed participants with varying musical abilities and sexes performed an attentional selection task that involved the recognition of target letters and musical notes, while their EEG signals were recorded from 128 sites.ResultsThe occipito/temporal N170 component of ERPs (170–210 ms) was found strictly left-sided during letter selection and bilateral (with a right-hemispheric tendency) during note selection. Source reconstruction data indicated the preponderant engagement of the right posterior fusiform gyrus (BA19) for processing musical notes. Also involved were other brain regions belonging to the word reading circuit, including the left-sided visual word form area (VWFA) and frontal eye-fields (FEFs).DiscussionThis finding provides an explanation for the infrequent appearance of musical alexia cases (previously observed only in patients with left hemispheric lesions). It also suggests how musical literacy could be a rehabilitative and preventive factor for dyslexia, by promoting neuroplasticity and bilaterality in the reading areas

The History of Developmental Psychology

The authors of this paper were invited to provide a chapter on how to teach “Developmental Psychology” (Daum & Manfredi, forthcoming) to the “International Handbook of Psychology Learning and Teaching” (Zumbach et al., forthcoming). When writing, the authors got lost in the details and wrote just a tiny little bit more than the editors asked for. In the end, we had to cut a substantial part of the chapter and decided to delete entire sections, one of them was the part on the “History of Developmental Psychology”. We nevertheless thought that the section could be of interest to somebody out there and put it as a preprint on the open science platform PsyArXiv. Enjoy reading

Neural correlates of sex differences in communicative gestures and speech comprehension: A preliminary study

The goal of this study was to investigate whether the semantic processing of the audiovisual combination of communicative gestures with speech differs between men and women. We recorded event-related brain potentials in women and men during the presentation of communicative gestures that were either congruent or incongruent with the speech.Our results showed that incongruent gestures elicited an N400 effect over frontal sites compared to congruent ones in both groups. Moreover, the females showed an earlier N2 response to incongruent stimuli than congruent ones, while larger sustained negativity and late positivity in response to incongruent stimuli was observed only in males. These results suggest that women rapidly recognize and process audiovisual combinations of communicative gestures and speech (as early as 300 ms) whereas men analyze them at the later stages of the process

The History of Developmental Psychology

The authors of this paper were invited to provide a chapter on how to teach “Developmental Psychology” (Daum & Manfredi, forthcoming) to the “International Handbook of Psychology Learning and Teaching” (Zumbach et al., forthcoming). When writing, the authors got lost in the details and wrote just a tiny little bit more than the editors asked for. In the end, we had to cut a substantial part of the chapter and decided to delete entire sections, one of them was the part on the “History of Developmental Psychology”. We nevertheless thought that the section could be of interest to somebody out there and put it as a preprint on the open science platform PsyArXiv. Enjoy reading