Auditory processing assessment in the perisylvian syndrome

Orientador: Marilisa Mantovani GuerreiroTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias MedicasResumo: A síndrome perisylviana (SP) refere-se a manifestações clínicas decorrentes de lesões na região perisylviana ou opercular. Caracteriza-se pela presença da polimicrogiria, uma malformação do desenvolvimento cortical em que o padrão normal de giros é substituído por múltiplos microgiros ao redor da fissura sylviana, agrupados e com sulcos pouco pronunciados entre eles, podendo ser vista em exame de neuroimagem. Estudos sugerem que distúrbios de linguagem e aprendizagem podem fazer parte desta síndrome, cuja clínica varia desde quadros específicos de linguagem até quadros mais amplos envolvendo sinais pseudobulbares e epilepsia. As áreas do processamento auditivo, representado por complexa resposta envolvendo habilidades corticais interconexas frente a um estímulo sonoro, podem estar comprometidas devido à proximidade com a fissura sylviana. Dessa forma, este estudo teve por objetivo avaliar os aspectos da linguagem, leitura e escrita e do processamento auditivo na SP e em escolares com ressonância magnética normal e correlacioná-los aos achados neurológicos, neuropsicológicos e de neuroimagem. Foram avaliados escolares com histórico de distúrbios de linguagem ou aprendizagem em presença de polimicrogiria perisylviana e em presença de neuroimagem normal, sendo submetidos a avaliações neurológica, neuropsicológica e fonoaudiológica, a qual incluiu avaliações de linguagem, leitura, escrita e processamento auditivo. Os resultados mostraram que o distúrbio específico de linguagem e os distúrbios de aprendizagem podem coexistir com o distúrbio do processamento auditivo e que os escolares com malformação do desenvolvimento cortical podem apresentar alterações neurolingüísticas mais significativas, concluindo que o córtex polimicrogírico pode se apresentar funcionalmente anormal e que as malformações corticais quando presentes devem ser consideradas fatores de risco para os distúrbios específicos de linguagem, distúrbios de aprendizagem e do processamento auditivoAbstract: Perisylvian syndrome (PS) comprises a variety of clinical manifestations due to lesions on the perisylvian or opercular regions. Bilateral perisylvian polymicrogyria is a malformation of cortical development characterized by excessively small gyri seen around the Sylvian fissure on magnetic resonance imaging. Studies suggest that language and learning impairment may be part of this syndrome, whose clinical may vary from specific language impairment to the severe cases involving pseudobulbar signs and epilepsy. The areas of auditory processing, a complex set of interdependent cortical abilities due to a sound stimulus, may be compromised because perisylvian areas harbor the auditory processing function. Thus, this study was to evaluate language, learning and auditory processing abilities in PS and in children with normal magnetic resonance imaging and associates them with the neuropsychological, neurological and neuroimaging findings. Children with a history of language and learning impairment in the presence of perisylvian polymicrogyria and in the presence of normal neuroimaging were assessed with neurological, neuropsychological and assessments of language, literacy and auditory processing. The results showed that the specific language impairment and learning disabilities can coexist with auditory processing disorder and children with malformation of cortical development may have more significant neurolinguistic deficits. Our study concluded that the polymicrogyric cortex can be functionally abnormal and display that cortical malformations if present should be considered risk factors for the specific language impairment, learning impairments and auditory processing disordersDoutoradoCiencias BiomedicasDoutor em Ciências Médica

Temporal auditory processing: correlation with developmental dyslexia and cortical malformation

processamento temporal auditivo e dislexia do desenvolvimento. caracterizar o processamento temporal auditivo em escolares com dislexia do desenvolvimento e correlacionar com malformação cortical.foram avaliados 20 escolares, com idade entre 8 e 14 anos, divididos em grupo experimental (GE) composto por 11 escolares (oito do gênero masculino) com o diagnóstico de dislexia do desenvolvimento e grupo controle (GC) composto por nove escolares (seis do gênero masculino) sem alterações neuropsicolinguísticas. Após avaliações neurológica, neuropsicológica e fonoaudiológica (avaliação de linguagem e leitura e escrita) para obtenção do diagnóstico, os escolares foram submetidos à avaliação audiológica periférica e posteriormente aplicou-se o teste Random Gap Detection Test e/ou Random Gap Detection Test Expanded. observou-se diferença estatisticamente significante entre os escolares do GE e GC, com pior desempenho para o GE. A maioria dos escolares do GE apresentou polimicrogiria perisylviana. escolares com dislexia do desenvolvimento podem apresentar alterações no processamento temporal auditivo com prejuízo no processamento fonológico. Malformação do desenvolvimento cortical pode ser o substrato anatômico dos distúrbios224537542CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP132461/2007-207/00806-4; 06/56257-6temporal auditory processing and developmental dyslexia. Aim: to characterize the temporal auditory processing in children with developmental dyslexia and to correlate findings with cortical malformations. Method: twenty school-aged children, ranging in age from 8 to 14 years were evaluated. These children were divided into two groups: the experimental group (EG) was composed by 11 children (eight were male) with developmental dyslexia and the control group (CG) was composed by nine normal children (six were male). After neurological assessment and verification of the intellectual level, language, reading and writing skills in order to determine the diagnosis, children underwent a peripheral audiological evaluation and Random Gap Detection Test and/or Random Gap Detection Test Expanded. Results: a statistically significant difference between children in the EG and CG were observed, with children in the EG presenting worst performances. Most of the children in the EG presented perisylvian polymicrogyria. Conclusion: children with developmental dyslexia may present temporal auditory processing disorders with deficits in phonological processing. Cortical malformations may be the anatomical substrate of these disorder

Cleft Palate Children: Performance In Auditory Processing Tests.

Many children with auditory processing disorders have a high prevalence of otitis media, a middle ear alterations greatly prevalent in children with palatine and lip clefts. To check the performance of children with palate cleft alone (PC) in auditory processing tests. Prospective study. Twenty children (7 to 11 years) with CP were submitted to sound location tests (SL), memory for verbal sounds (MSSV) and non verbal sounds in sequence (MSSNV), Revised auditory fusion (AFT-R), Pediatric test of speech intelligibility/synthetic sentences (PSI/SSI), alternate disyllables (SSW) and digit dichotic (DD). The children performances in the tests were classified in bad and good. There was no statistically significant difference between genders and ears. The average values obtained were 2.16, 2.42, 4.37, 60.50 ms; 40.71 to 67.33%; 96.25 to 99.38%; 73.55 to 73.88% and 58.38 to 65.47% respectively for the MSSNV, MSSV, LS, AFT-R, PSI/SSI tests with ipsilateral (PSI/SSIMCI) and contralateral (PSI/SSI/MCC) competitive message, DD and SSW tests. A high percentage of children showed worse results in the AFT-R, DD, SSW tests and in the PSI/SSIMCI tests. The best performances happened in the sound location tests, verbal and non-verbal sounds for sequential memory and for PSI/SSIMCC tests.75213-2

Language And Central Temporal Auditory Processing In Childhood Epilepsies

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Because of the relationship between rolandic, temporoparietal, and centrotemporal areas and language and auditory processing, the aim of this study was to investigate language and central temporal auditory processing of children with epilepsy (rolandic epilepsy and temporal lobe epilepsy) and compare these with those of children without epilepsy. Thirty-five children aged between eight and 14 years old were studied. Two groups of children participated in this study: a group with childhood epilepsy (n=19), and a control group without epilepsy or linguistic changes (n=16). There was a significant difference between the two groups, with the worst performance in children with epilepsy for the gaps-in-noise test, right ear (p < 0.001) and left ear (p < 0.001) tests, and duration pattern test - naming (p = 0.002) and humming (p = 0.002). In auditory P300, there was no significant difference in latency (p=0.343) and amplitude (p=0.194) between the groups. There was a significant difference between the groups, with the worst performance in children with epilepsy, for the auditory-receptive vocabulary (PPVT) (p < 0.001) and phonological working memory (nonwords repetition task) tasks (p = 0.001). We conclude that the impairment of central temporal auditory processing and language skillsmay be comorbidities in children with rolandic epilepsy and temporal lobe epilepsy. (C) 2015 Elsevier Inc. All rights reserved.53180183Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)FAPESP [2010/07438-3

Temporal auditory processing: correlation with developmental dyslexia and cortical malformation

TEMA: processamento temporal auditivo e dislexia do desenvolvimento. OBJETIVO: caracterizar o processamento temporal auditivo em escolares com dislexia do desenvolvimento e correlacionar com malformação cortical. MÉTODO: foram avaliados 20 escolares, com idade entre 8 e 14 anos, divididos em grupo experimental (GE) composto por 11 escolares (oito do gênero masculino) com o diagnóstico de dislexia do desenvolvimento e grupo controle (GC) composto por nove escolares (seis do gênero masculino) sem alterações neuropsicolinguísticas. Após avaliações neurológica, neuropsicológica e fonoaudiológica (avaliação de linguagem e leitura e escrita) para obtenção do diagnóstico, os escolares foram submetidos à avaliação audiológica periférica e posteriormente aplicou-se o teste Random Gap Detection Test e/ou Random Gap Detection Test Expanded. RESULTADOS: observou-se diferença estatisticamente significante entre os escolares do GE e GC, com pior desempenho para o GE. A maioria dos escolares do GE apresentou polimicrogiria perisylviana. CONCLUSÃO: escolares com dislexia do desenvolvimento podem apresentar alterações no processamento temporal auditivo com prejuízo no processamento fonológico. Malformação do desenvolvimento cortical pode ser o substrato anatômico dos distúrbios.BACKGROUND: temporal auditory processing and developmental dyslexia. AIM: to characterize the temporal auditory processing in children with developmental dyslexia and to correlate findings with cortical malformations. METHOD: twenty school-aged children, ranging in age from 8 to 14 years were evaluated. These children were divided into two groups: the experimental group (EG) was composed by 11 children (eight were male) with developmental dyslexia and the control group (CG) was composed by nine normal children (six were male). After neurological assessment and verification of the intellectual level, language, reading and writing skills in order to determine the diagnosis, children underwent a peripheral audiological evaluation and Random Gap Detection Test and/or Random Gap Detection Test Expanded. RESULTS: a statistically significant difference between children in the EG and CG were observed, with children in the EG presenting worst performances. Most of the children in the EG presented perisylvian polymicrogyria. CONCLUSION: children with developmental dyslexia may present temporal auditory processing disorders with deficits in phonological processing. Cortical malformations may be the anatomical substrate of these disorders

Auditory processing disorder in perisylvian syndrome

We hypothesized that the processing of auditory information by the perisylvian polymicrogyric cortex may be different from the normal cortex. To characterize the auditory processing in bilateral perisylvian syndrome, we examined ten patients with perisylvian polymicrogyria (Group 1) and seven control children (Group 11). Group I was composed by four children with bilateral perisylvian polymicrogyria and six children with bilateral posterior perisylvian polymicrogyria. The evaluation included neurological and neuroimaging investigation, intellectual quotient and audiological assessment (audiometry and behavior auditory tests). The results revealed a statistically significant difference between the groups in the behavioral auditory tests, Such as, digits dichotic test, nonverbal dichotic test (specifically in right attention), and random gap detection/random gap detection expanded tests. Our data showed abnormalities in the auditory processing of children with perisylvian polymicrogyria, suggesting that perisylvian polymicrogyric cortex is functionally abnormal. We also found a correlation between the severity of our auditory findings and the extent of the cortical abnormality. (C) 2009 Elsevier B.V. All rights reserved.CNPq[132461/2007-2]FAPESP[07/00806-4]FAPESP[06/56257-6

Auditory Processing Disorder In Perisylvian Syndrome.

We hypothesized that the processing of auditory information by the perisylvian polymicrogyric cortex may be different from the normal cortex. To characterize the auditory processing in bilateral perisylvian syndrome, we examined ten patients with perisylvian polymicrogyria (Group I) and seven control children (Group II). Group I was composed by four children with bilateral perisylvian polymicrogyria and six children with bilateral posterior perisylvian polymicrogyria. The evaluation included neurological and neuroimaging investigation, intellectual quotient and audiological assessment (audiometry and behavior auditory tests). The results revealed a statistically significant difference between the groups in the behavioral auditory tests, such as, digits dichotic test, nonverbal dichotic test (specifically in right attention), and random gap detection/random gap detection expanded tests. Our data showed abnormalities in the auditory processing of children with perisylvian polymicrogyria, suggesting that perisylvian polymicrogyric cortex is functionally abnormal. We also found a correlation between the severity of our auditory findings and the extent of the cortical abnormality.32299-30