MOCCA-SURVEY database I. Accreting white dwarf binary systems in globular clusters -- IV. cataclysmic variables -- properties of bright and faint populations

We investigate here populations of cataclysmic variables (CVs) in a set of 288 globular cluster (GC) models evolved with the MOCCA code. This is by far the largest sample of GC models ever analysed with respect to CVs. Contrary to what has been argued for a long time, we found that dynamical destruction of primordial CV progenitors is much stronger in GCs than dynamical formation of CVs, and that dynamically formed CVs and CVs formed under no/weak influence of dynamics have similar white dwarf mass distributions. In addition, we found that, on average, the detectable CV population is predominantly composed of CVs formed via typical common envelope phase (CEP) ($\gtrsim70$ per cent), that only $\approx2-4$ per cent of all CVs in a GC is likely to be detectable, and that core-collapsed models tend to have higher fractions of bright CVs than non-core-collapsed ones. We also consistently show, for the first time, that the properties of bright and faint CVs can be understood by means of the pre-CV and CV formation rates, their properties at their formation times and cluster half-mass relaxation times. Finally, we show that models following the initial binary population proposed by Kroupa and set with low CEP efficiency better reproduce the observed amount of CVs and CV candidates in NGC 6397, NGC 6752 and 47 Tuc. To progress with comparisons, the essential next step is to properly characterize the candidates as CVs (e.g. by obtaining orbital periods and mass ratios).Comment: 18 pages, 13 figures; accepted for publication in MNRA

Visible camera cryostat design and performance for the SuMIRe Prime Focus Spectrograph (PFS)

We describe the design and performance of the SuMIRe Prime Focus Spectrograph (PFS) visible camera cryostats. SuMIRe PFS is a massively multi-plexed ground-based spectrograph consisting of four identical spectrograph modules, each receiving roughly 600 fibers from a 2394 fiber robotic positioner at the prime focus. Each spectrograph module has three channels covering wavelength ranges 380~nm -- 640~nm, 640~nm -- 955~nm, and 955~nm -- 1.26~um, with the dispersed light being imaged in each channel by a f/1.07 vacuum Schmidt camera. The cameras are very large, having a clear aperture of 300~mm at the entrance window, and a mass of $\sim$280~kg. In this paper we describe the design of the visible camera cryostats and discuss various aspects of cryostat performance

Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver

Disturbances in protein folding and membrane compositions in the endoplasmic reticulum (ER) elicit the unfolded protein response (UPR). Each of three UPR sensory proteins-PERK (PEK/EIF2AK3), IRE1, and ATF6-is activated by ER stress. PERK phosphorylation of eIF2 represses global protein synthesis, lowering influx of nascent polypeptides into the stressed ER, coincident with preferential translation of ATF4 (CREB2). In cultured cells, ATF4 induces transcriptional expression of genes directed by the PERK arm of the UPR, including genes involved in amino acid metabolism, resistance to oxidative stress, and the proapoptotic transcription factor CHOP (GADD153/DDIT3). In this study, we characterize whole-body and tissue-specific ATF4-knockout mice and show in liver exposed to ER stress that ATF4 is not required for CHOP expression, but instead ATF6 is a primary inducer. RNA-Seq analysis indicates that ATF4 is responsible for a small portion of the PERK-dependent UPR genes and reveals a requirement for expression of ATF4 for expression of genes involved in oxidative stress response basally and cholesterol metabolism both basally and under stress. Consistent with this pattern of gene expression, loss of ATF4 resulted in enhanced oxidative damage, and increased free cholesterol in liver under stress accompanied by lowered cholesterol in sera

Using the methods to calculate parameters of drilling and blasting operations for emulsion explosives

Mathematical modelling of rock mass breaking using blasting has been applied to obtain formulas for the calculation of crush zone radii, intensive fragmentation, and crack formation around the charging cavity in the structure, diameter of the charging cavity, diameter of the charge itself, detonation characteristics of an explosive, boundaries of the rock strength, rock mass jointing, and mineral compression under the effect of rock pressure. The methods have been developed to calculate parameters of drilling and blasting operations (DBOs) while driving the mine workings based upon the idea of the arrangement of blastholes in terms of areas they occupy in a fore-breast as well as upon their location relative to break-off outline. Stage one of the methods involves calculating and designing burn cuts where a distance between blastholes is determined with the help of a fragmentation zone radius. Stage two means calculation of both specific and total explosion consumption per borehole bottom, line of least resistance (LLR) for a borehole in terms of intensive fragmentation, areas of borehole groups, borehole number, analytical and actual distance between boreholes, actual charge amount per borehole, and actual specific and the total explosive (E) consumption per borehole bottom. The methods have been tested in the operating ore mine while driving a mine working. Emulsion explosive (EE) Ukrayinit-PP-2 (Україніт-ПП-2) has been applied. The developed methods have been used to calculate DBOs parameters for the explosive. Trial blasts demonstrated the good firing of a borehole bottom and uniform ore fragmentation; a high coefficient of borehole use has been supported

GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment

The antileukemic agent asparaginase triggers the amino acid response (AAR) in the liver by activating the eukaryotic initiation factor 2 (eIF2) kinase general control nonderepressible 2 (GCN2). To explore the mechanism by which AAR induction is necessary to mitigate hepatic lipid accumulation and prevent liver dysfunction during continued asparaginase treatment, wild-type and Gcn2 null mice were injected once daily with asparaginase or phosphate buffered saline for up to 14 days. Asparaginase induced mRNA expression of multiple AAR genes and greatly increased circulating concentrations of the metabolic hormone fibroblast growth factor 21 (FGF21) independent of food intake. Loss of Gcn2 precluded mRNA expression and circulating levels of FGF21 and blocked mRNA expression of multiple genes regulating lipid synthesis and metabolism including Fas, Ppara, Pparg, Acadm, and Scd1 in both liver and white adipose tissue. Furthermore, rates of triglyceride export and protein expression of apolipoproteinB-100 were significantly reduced in the livers of Gcn2 null mice treated with asparaginase, providing a mechanistic basis for the increase in hepatic lipid content. Loss of AAR-regulated antioxidant defenses in Gcn2 null livers was signified by reduced Gpx1 gene expression alongside increased lipid peroxidation. Substantial reductions in antithrombin III hepatic expression and activity in the blood of asparaginase-treated Gcn2 null mice indicated liver dysfunction. These results suggest that the ability of the liver to adapt to prolonged asparaginase treatment is influenced by GCN2-directed regulation of FGF21 and oxidative defenses, which, when lost, corresponds with maladaptive effects on lipid metabolism and hemostasis