Sequential prostate MRI reporting in men on active surveillance: initial experience of a dedicated PRECISE software program

BACKGROUND AND OBJECTIVES: There is interest in using sequential multiparametric magnetic resonance imaging (mpMRI) to assess men on active surveillance (AS) for prostate cancer. The Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) recommendations propose standardised reporting mpMRI data for these men. This includes accurate size measurements of lesions over time, but such approach is time consuming for the radiologist and there is a strong need of dedicated tools to report serial scans in a systematic manner. We present the results from an initial validation cohort using dedicated PRECISE reporting software to allow automated comparison between sequential scans on AS. MATERIALS AND METHODS: We retrospectively analysed baseline and follow-up scans of 20 men randomised to 6 months of daily dutasteride (n = 10) or placebo (n = 10) from the MAPPED trial. Men underwent 3T mpMRI at baseline and after 6 months, and a dedicated radiologist reported the scans using both a widespread commercially-available platform (Osirix®) and a semi-automated dedicated PRECISE reporting tool (MIM®). Tumour volume by planimetry in all sequences and conspicuity on diffusion-weighted imaging were assessed. Reporting time was recorded, and we used the Wilcoxon test for statistical analysis. RESULTS: Median tumour volumes and conspicuity were similar using both approaches. The reporting time of the follow-up scan was quicker using the PRECISE reporting workflow both in the whole population (12'33″ vs 10'52″; p = 0.005) and in the dutasteride arm (15'50″ vs 12'59″; p = 0.01). A structured report including clinical and imaging data was generated according to the PRECISE recommendations and a comparison table between lesion characteristics at baseline and follow-up scans was also included. CONCLUSION: We conclude that a dedicated PRECISE reporting tool for sequential scans in men on AS results in a significant reduction in the reporting time and allows the radiologist to easily compare scans over time. This tool will help with our understanding of the natural history of mpMRI changes during AS

Real-time buffer gas pressure tuning in a micro-machined vapor cell

We demonstrate a controllable depletion of the nitrogen buffer gas pressure in a micro-machined cesium (Cs) vapor cell from the dynamic heating of an alkali dispenser pill. When the alkali source is laser activated, the gettering compounds within the alkali pill dispenser reduce the nitrogen (N$_2$) content from the vapor for fine-tuning of the alkali to buffer gas pressure ratio. Additionally, we decrease the buffer gas pressure below 100$\,$mTorr to evaluate the presence of other potential broadening mechanisms. Real-time control of the gas pressure ratio in the vapor cell will have notable benefits for refining atomic sensor performance and provide a routine to achieve various target pressures across a wafer bonded with a uniform back-filled buffer gas pressure.Comment: 5 pages, 4 figure

Micro-machined deep silicon atomic vapor cells

Using a simple and cost-effective water jet process, silicon etch depth limitations are overcome to realize a 6 mm deep atomic vapor cell. While the minimum silicon feature size was limited to a 1.5 mm width in these first generation vapor cells, we successfully demonstrate a two-chamber geometry by including a [Formula: see text] mm meandering channel between the alkali pill chamber and the main interrogation chamber. We evaluate the impact of the channel conductance on the introduction of the alkali vapor density during the pill activation process and mitigate glass damage and pill contamination near the main chamber. Finally, we highlight the improved signal achievable in the 6 mm silicon cell compared to standard 2 mm path length silicon vapor cells

Nitrogen buffer gas pressure tuning in a micro-machined vapor cell

We demonstrate a controllable depletion of the nitrogen buffer gas pressure in a micro-machined cesium (Cs) vapor cell from the dynamic heating of an alkali dispenser pill. When the alkali source is laser activated, the gettering compounds within the alkali pill dispenser reduce the nitrogen (N2) content from the vapor for fine-tuning of the alkali to buffer gas pressure ratio, with a demonstrated pressure step size as low as 1 Torr. Additionally, we decrease the buffer gas pressure below 100 mTorr to evaluate the presence of other potential broadening mechanisms. Real-time control of the gas pressure ratio in the vapor cell will have notable benefits for refining atomic sensor performance and provide a routine to achieve various target pressures across a wafer bonded with a uniform back-filled buffer gas pressure

Nondestructive Evaluation & Radar Imaging using Terahertz Signals

Nondestructive imaging is a method of examining a material without direct contact that additionally does not alter the properties of the material. The terahertz imaging system currently in development uses the principle of interferometry (a Michelson Interferometer) such that frequency modulated terahertz signals are split and directed to the object under study and a reference mirror; then the detector will acquire the intensity of the combined reflected signals that contains information about the objects in the path of the beam.https://corescholar.libraries.wright.edu/urop_celebration/1018/thumbnail.jp

Influence of supernatants from polymorphonuclear leucocytes on blastogenesis of syngeneic and allogeneic murine splenocytes.

Supernatant was produced from activated peritoneal polymorphonuclear leucocyte-rich cell populations from different strains of mice. These supernatants were studied for their ability to modify spontaneous and mitogen-induced blastogenesis of syngeneic and allogeneic splenocytes. Our results indicate that polymorphonuclear leucocyte-rich cell cultures from two strains of mice, A/J and BALB/c, produced a supernatant that could enhance PHA-induced blastogenesis of syngeneic and allogeneic splenocytes. Cells from a third strain C57B1/6, did not produce an active supernatant. In general, the response by splenocytes from these three strains paralleled the production of active supernatant that we observed. The response to the active supernatant was dependent upon the mitogen stimulation of the splenocytes, the mitogen dilution and the supernatant activity. These functions are believed to be genetically determined