Human malarial disease: a consequence of inflammatory cytokine release

Malaria causes an acute systemic human disease that bears many similarities, both clinically and mechanistically, to those caused by bacteria, rickettsia, and viruses. Over the past few decades, a literature has emerged that argues for most of the pathology seen in all of these infectious diseases being explained by activation of the inflammatory system, with the balance between the pro and anti-inflammatory cytokines being tipped towards the onset of systemic inflammation. Although not often expressed in energy terms, there is, when reduced to biochemical essentials, wide agreement that infection with falciparum malaria is often fatal because mitochondria are unable to generate enough ATP to maintain normal cellular function. Most, however, would contend that this largely occurs because sequestered parasitized red cells prevent sufficient oxygen getting to where it is needed. This review considers the evidence that an equally or more important way ATP deficency arises in malaria, as well as these other infectious diseases, is an inability of mitochondria, through the effects of inflammatory cytokines on their function, to utilise available oxygen. This activity of these cytokines, plus their capacity to control the pathways through which oxygen supply to mitochondria are restricted (particularly through directing sequestration and driving anaemia), combine to make falciparum malaria primarily an inflammatory cytokine-driven disease

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Global dynamic scenarios in a discrete-time model of renewable resource exploitation: a mathematical study

We consider the two-dimensional map introduced in Bischi et al. (J Differ Equ Appl 21(10):954–973, 2015) formulated as a model for a renewable resource exploitation process in an evolutionary setting. The global dynamic scenarios displayed by the model are not so often encountered in smooth two-dimensional dynamical systems. We explain the occurrence of such scenarios at the light of the theory of noninvertible maps. Moreover, complex structures of basins of attraction of coexisting invariant sets are observed. We analyze such structures by examining stability properties of chaotic sets, in the case in which a non-topological Milnor attractor is present. Stability changes of a chaotic set occur through global bifurcations (such as riddling and blowout) and are detected by means of the study of the spectrum of Lyapunov exponents associated with the set