The comparison of neuropsychological performance in the girl students with social anxiety disorder and normal students

Background and aims: The Neuropsychological performance in patients with anxiety disorders has received much less attention. The present study set out to compare one of the executive performances that means shifting function in two groups of social anxious and normal. Also, The aim of the present study was to investigate performance in this function both of processing efficacy and performance effectiveness. Methods: In this causal-comparative study, recruited 24 patients with social anxiety disorder and 24 non patients in multi-stage cluster sampling method and were implemented tests of Connor Social Anxiety Scale, Self-reported mental effort scale, and Wisconsin Card Sorting Test, The results were analyzed with SPSS software and MANOVA test. Results: The results showed significant differences between the two groups in both components of performance in the shifting function namely processing efficacy (P<0.001) and performance effectiveness (P<0.001), So that socially anxious group showed poorer performance. Conclusion: The group of social anxious in compare with normal group showed deficient in the shifting function of working memory. The deficiency observed were related to cognitive models of anxiety disorders specially Attentional Control Theory

Impact of Rifampin Induction on the Fermentation Production of Ganoderic Acids by Medicinal Mushroom Ganoderma lucidum

Backgrounds and Objectives: Ganoderic acids are the most valuable secondary metabolites in Ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. However, application of ganoderic acids is limited due to low yield production. Recently, it was shown that static liquid culture could be a proven technology for producing ganoderic acids in Ganoderma lucidum, and that applying elicitors could be a potential strategy to improve their production. Materials and Methods: In this work, the effect of rifampin, a cyto-chromes P450 inducer, on production of ganoderic acids was studied, and Response Surface Methodology was applied to optimize the elicitor induction. Then total ganoderic acid in the harvested mycelia was extracted and its absorbency was measured. Results and Conclusion: The results showed an increase in the concen-tration of ganoderic acid in all samples. Moreover, optimum concentration and induction time of rifampin were obtained. The proposed model predicted the maximum ganoderic acid production as 18.6 mg g-1 in which the optimal concentration and time induction obtained were 100 μM and day 9, respectively. This work demonstrated a useful method for the enhanced production of ganoderic acids by Ganoderma lucidum.