Reconceptualizing Indigeneity Within the Fraternity and Sorority Community

The purpose of this article provides fraternity and sorority communities with an understanding of the impact of a Native American sisterhood on the cultivation in how it conceptualized itself, its centering an Indigenous structure, and how it affirms the women who join through building relationality. Through the first research inquiry of a Native American sisterhood, the findings reveal/highlight how the sisterhood has centered Indigeneity in its conception to how it lives today. Fraternity and sorority communities need to shift their culture to honor Indigenous ways of being

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases

During the course of our research on the lead optimisation of the NBTI (Novel Bacterial Type II Topoisomerase Inhibitors) class of antibacterials, we discovered a series of tricyclic compounds that showed good Gram-positive and Gram-negative potency. Herein we will discuss the various subunits that were investigated in this series and report advanced studies on compound 1 (GSK945237) which demonstrates good PK and in vivo efficacy properties

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

During the course of our research to find novel mode of action antibacterials, we discovered a series of hydroxyl tricyclic compounds that showed good potency against Gram-positive and Gram-negative pathogens. These compounds inhibit bacterial type IIA topoisomerases. Herein we will discuss structure–activity relationships in this series and report advanced studies on compound 1 (GSK966587) which demonstrates good PK and in vivo efficacy properties. X-ray crystallographic studies were used to provide insight into the structural basis for the difference in antibacterial potency between enantiomers