U.S. Migration and Reproductive Health among Mexican Women: Assessing the Evidence for Health Selectivity

Health selectivity posits that individuals who practice preventive health behaviors are more likely to migrate to the United States, and this has been proposed as one explanation of the Latino Paradox. This paper examines evidence for health selection in the context of reproductive health using national survey data from Mexico (the longitudinal Mexico Family Life Survey [MxFLS], 2002 and 2005 waves) and the United States (the National Survey of Family Growth [NSFG], 2002). We compared sexual behaviors and contraceptive practices of Mexican women residing in Mexico who subsequently migrated to the United States with those who remained in Mexico and with Mexican immigrants in the United States. MxFLS respondents who migrated to the United States had a younger mean age, and a larger proportion had no children compared to MxFLS nonmigrants. Within the MxFLS sample, a smaller proportion of women who migrated had ever had vaginal sex, though this difference was nonsignificant with adjustment for sociodemographic factors. No sexual behavior or contraceptive use measures varied between Mexican migrants and nonmigrants within the MxFLS. The mean lifetime number of sexual partners was lower for MxFLS respondents than for Mexican immigrants in the NSFG. Smaller proportions of MxFLS respondents reported using hormonal methods or condoms relative to NSFG respondents. We found no evidence for health selectivity with regard to sexual behaviors or contraceptive practices, underscoring the importance of continued attention to the factors that influence the adaptation trajectories following U.S. migration.L’hypothèse de la sélection par la santé selon laquelle les individus qui adoptent des comportements de prévention sont plus susceptibles d’immigrer aux Etats-Unis, a été proposée comme une explication au paradoxe latino. Cet article examine les signes de sélection par la santé dans le contexte de la santé en matière de procréation sur la base des données de deux enquêtes nationales, l’une réalisée au Mexique (l’étude longitudinale Mexico Family Life Survey [MxFLS], vagues 2002 et 2005) et l’autre aux Etats-Unis (l’étude National Survey of Family Growth [NSFG], 2002). Nous avons comparé les comportements sexuels et les pratiques de contraception de femmes mexicaines résidant au Mexique qui ont par la suite immigré aux Etats-Unis avec ceux de femmes qui sont restées au Mexique et ceux d’immigrantes mexicaines aux Etats-Unis. Les personnes de l’étude MxFLS qui ont immigré aux Etats-Unis, avaient un âge moyen inférieur et étaient plus nombreuses à ne pas avoir d’enfants, en comparaison aux non-migrantes de l’étude MxFLS. Dans l’étude MxFLS, une plus faible proportion des femmes qui avaient immigré ont déclaré avoir déjà eu des rapports sexuels, mais cette différence était non significative après ajustement des facteurs sociodémographiques. Aucune variation n’a été constatée dans les mesures de comportement sexuel et d’utilisation de contraceptifs entre les immigrantes mexicaines et les non immigrantes dans l’étude MxFLS. Le nombre moyen de partenaires sexuels dans une vie était inférieur chez les femmes de l'étude MxFLS à celui relevé chez les immigrantes mexicaines de l’étude NSFG. Le recours à des contraceptifs hormonaux ou à des préservatifs était plus faible dans l’étude MxFLS que dans l’étude NSFG. Nous n’avons trouvé aucune preuve de sélection par la santé concernant les comportements sexuels ou les pratiques de contraception, ce qui souligne l’importance qu'il y a à continuer à surveiller les facteurs qui influencent les trajectoires d’adaptation après immigration aux Etats-Unis.La selección en términos de salud postula que los individuos que practican hábitos saludables preventivos tienen más probabilidades de emigrar a los Estados Unidos, y esto se ha propuesto como una explicación de la Paradoja Latina. Este artículo examina la evidencia de la selección en términos de salud en el contexto de la salud reproductiva, utilizando datos de encuestas nacionales efectuadas en México (Encuesta Longitudinal sobre la Vida Familiar en México [MxFLS], fases 2002 y 2005) y en los Estados Unidos (Encuesta Nacional sobre Crecimiento Familiar [NSFG], 2002). Comparamos los comportamientos sexuales y las prácticas anticonceptivas de mujeres mexicanas que residían en México y que posteriormente emigraron a los Estados Unidos con los de aquellas que se quedaron en México y con los de inmigrantes mexicanas en los Estados Unidos. Las encuestadas de la MxFLS que emigraron a los Estados Unidos tenían una edad media menor y una gran proporción no tuvo hijos en comparación con las no inmigrantes de la MxFLS. En la muestra de la MxFLS, una proporción más pequeña de mujeres que emigraron jamás había tenido sexo vaginal, aunque esta diferencia no fue significativa con el ajuste de los factores sociodemográficos. Los indicadores de ninguna conducta sexual o uso de anticonceptivos variaron entre emigrantes y no emigrantes mexicanas en la MxFLS. El número medio de parejas sexuales de por vida fue más bajo en las entrevistadas de la MxFLS que en las inmigrantes mexicanas en la NSFG. Una menor proporción de las entrevistadas de la MxFLS informaron sobre el uso de métodos hormonales o preservativos con respeto a las entrevistadas de la NSFG. No encontramos ninguna evidencia de la selección en términos de salud con respecto a los comportamientos sexuales o las prácticas anticonceptivas, subrayando la importancia de una atención continuada a los factores que influyen en las trayectorias de adaptación que hay tras la migración a los EE. UU

Change in condom and other barrier method use during and after an HIV prevention trial in Zimbabwe

<p>Abstract</p> <p>Background</p> <p>We examined the use of male condoms and the diaphragm following completion of a clinical trial of the diaphragm's HIV prevention effectiveness. In the trial, called Methods for Improving Reproductive Health in Africa (MIRA), women were randomized to a diaphragm group (diaphragm, gel and condoms) or a condom-only control group. At trial exit, all women were offered the diaphragm and condoms.</p> <p>Methods</p> <p>Our sample consisted of 801 Zimbabwean MIRA participants who completed one post-trial visit (median lapse: nine months; range two to 20 months). We assessed condom, diaphragm and any barrier method use at last sex act at enrolment, final MIRA and post-trial visits. We used multivariable random effects logistic regression to examine changes in method use between these three time points.</p> <p>Results and discussion</p> <p>In the condom group, condom use decreased from 86% at the final trial visit to 67% post trial (AOR = 0.20; 95% CI: 0.12 to 0.33). In the diaphragm group, condom use was 61% at the final trial visit, and did not decrease significantly post trial (AOR = 0.77; 95% CI: 0.55 to 1.09), while diaphragm use decreased from 79% to 50% post trial (AOR = 0.18; 95% CI: 0.12 to 0.28). Condom use significantly decreased between the enrolment and post-trial visits in both groups. Use of any barrier method was similar in both groups: it significantly decreased between the final trial and the post-trial visits, but did not change between enrolment and the post-trial visits.</p> <p>Conclusions</p> <p>High condom use levels achieved during the trial were not sustained post trial in the condom group. Post-trial diaphragm use remained relatively high in the diaphragm group (given its unknown effectiveness), but was very low in the condom group. Introducing "new" methods for HIV prevention may require time and user skills before they get adopted. Our findings underscore the potential benefit of providing a mix of methods to women as it may encourage more protected acts.</p

Impact of Adverse Childhood Experiences on Intimate Partner Violence Perpetration among Sri Lankan Men

In Sri Lanka, over one in three women experience intimate partner violence (IPV) victimization in their lifetime, making it a serious public health concern. Adverse childhood experiences (ACEs) such as child abuse and neglect, witnessing domestic violence, parental separation, and bullying are also widespread. Studies in Western settings have shown positive associations between ACEs and IPV perpetration in adulthood, but few have examined this relationship in a non-Western context. In the present study, we examined the association of ACEs with IPV perpetration among Sri Lankan men surveyed for the UN Multi-Country Study on Men and Violence in Asia and the Pacific. We found statistically significant positive associations between the number of ACE categories (ACE score) and emotional, financial, physical, and sexual IPV perpetration among Sri Lankan men. We analyzed the contributions of each ACE category and found that childhood abuse was strongly associated with perpetration of IPV in adulthood, with sexual abuse associated with the greatest increase in odds of perpetration (Adjusted odds ratio 2.36; 95% confidence interval: 1.69, 3.30). Witnessing abuse of one’s mother was associated with the greatest increase in the odds of perpetrating physical IPV (AOR 1.82; 95% CI: 1.29, 2.58), while lack of a male parental figure was not associated with physical IPV perpetration (AOR 0.76; 95% CI: 0.53, 1.09). These findings support a social learning theory of IPV perpetration, in which children who are exposed to violence learn to perpetrate IPV in adulthood. They also suggest that in Sri Lanka, being raised in a female-headed household does not increase the risk of IPV perpetration in adulthood compared to being raised in a household with a male parental figure. The relationship between being raised in a female-headed household (the number of which increased dramatically during Sri Lanka’s recent civil war) and perpetration of IPV warrants further study. Interventions that aim to decrease childhood abuse in Sri Lanka could both protect children now and reduce IPV in the future, decreasing violence on multiple fronts

Migration Decision-Making Among Mexican Youth: Individual, Family, and Community Influences

We explored migration decisions using in-depth, semi-structured interviews with male and female youth ages 14 to 24 (n=47) from two Mexican communities, one with high and one with low U.S. migration density. Half were return migrants and half were non-migrants with relatives in the U.S. Migrant and non-migrant youth expressed different preferences, especially in terms of education and their ability to wait for financial gain. Reasons for migration were mostly similar across the two communities; however, the perceived risk of the migration journey was higher in the low density migration community while perceived opportunities in Mexico were higher in the high density migration community. Reasons for return were related to youths’ initial social and economic motivations for migration. A greater understanding of factors influencing migration decisions may provide insight into the vulnerability of immigrant youth along the journey, their adaptation process in the U.S., and their reintegration in Mexico

The male factor: Outcomes from a cluster randomized field experiment with a couples-based HIV prevention intervention in a South African township

This study examined the effects of the Couples Health CoOp intervention on heavy drinking, condom use, and HIV incidence

Pregnancy Intentions and Teenage Pregnancy Among Latinas: A Mediation Analysis

The extent to which pregnancy intentions mediate the relationship between individual, familial and cultural characteristics and adolescent pregnancy is not well understood. The role of intentions may be particularly important among Latina teenagers, whose attitudes toward pregnancy are more favorable than those of other groups and whose pregnancy rates are high

A Trajectory Analysis of Alcohol and Marijuana Use Among Latino Adolescents in San Francisco, California

We examined alcohol and marijuana use trajectories among Latino adolescents in the San Francisco Bay Area

Biomarker Validation of Reports of Recent Sexual Activity: Results of a Randomized Controlled Study in Zimbabwe

Challenges in the accurate measurement of sexual behavior in human immunodeficiency virus (HIV) prevention research are well documented and have prompted discussion about whether valid assessments are possible. Audio computer-assisted self-interviewing (ACASI) may increase the validity of self-reported behavioral data. In 2006–2007, Zimbabwean women participated in a randomized, cross-sectional study that compared self-reports of recent vaginal sex and condom use collected through ACASI or face-to-face interviewing (FTFI) with a validated objective biomarker of recent semen exposure (prostate-specific antigen (PSA) levels). Of 910 study participants, 196 (21.5%) tested positive for PSA, an indication of semen exposure during the previous 2 days. Of these 196 participants, 23 (11.7%) reported no sex in the previous 2 days, with no difference in reported sexual activity between interview modes (12.5% ACASI vs. 10.9% FTFI; Fisher's exact test: P = 0.72). In addition, 71 PSA-positive participants (36.2%) reported condom-protected vaginal sex only; their reports also indicated no difference between interview modes (33.7% ACASI vs. 39.1% FTFI; P = 0.26). Only 52% of PSA-positive participants reported unprotected sex during the previous 2 days. Self-report was a poor predictor of recent sexual activity and condom use in this study, regardless of interview mode, providing evidence that such data should be interpreted cautiously

MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments

Background: Oral and vaginal preparations of tenofovir as pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) infection have demonstrated variable efficacy in men and women prompting assessment of variation in drug concentration as an explanation. Knowledge of tenofovir concentration and its active form, tenofovir diphosphate, at the putative vaginal and rectal site of action and its relationship to concentrations at multiple other anatomic locations may provide key information for both interpreting PrEP study outcomes and planning future PrEP drug development. Objective: MTN-001 was designed to directly compare oral to vaginal steady-state tenofovir pharmacokinetics in blood, vaginal tissue, and vaginal and rectal fluid in a paired cross-over design. Methods and Findings: We enrolled 144 HIV-uninfected women at 4 US and 3 African clinical research sites in an open label, 3-period crossover study of three different daily tenofovir regimens, each for 6 weeks (oral 300 mg tenofovir disoproxil fumarate, vaginal 1% tenofovir gel [40 mg], or both). Serum concentrations after vaginal dosing were 56-fold lower than after oral dosing (p<0.001). Vaginal tissue tenofovir diphosphate was quantifiable in ≥90% of women with vaginal dosing and only 19% of women with oral dosing. Vaginal tissue tenofovir diphosphate was ≥130-fold higher with vaginal compared to oral dosing (p<0.001). Rectal fluid tenofovir concentrations in vaginal dosing periods were higher than concentrations measured in the oral only dosing period (p<0.03). Conclusions: Compared to oral dosing, vaginal dosing achieved much lower serum concentrations and much higher vaginal tissue concentrations. Even allowing for 100-fold concentration differences due to poor adherence or less frequent prescribed dosing, vaginal dosing of tenofovir should provide higher active site concentrations and theoretically greater PrEP efficacy than oral dosing; randomized topical dosing PrEP trials to the contrary indicates that factors beyond tenofovir's antiviral effect substantially influence PrEP efficacy. Trial Registration: ClinicalTrials.gov NCT00592124

Stigma in the health clinic and implications for PrEP access and use by adolescent girls and young women : conflicting perspectives in South Africa

DATA AVAILABILITY : Data and materials are available on request from Dr. Wendee Wechsberg at [email protected] : Globally, an urgent need exists to expand access to HIV prevention among adolescent girls and young women (AGYW), but the need is particularly acute in sub-Saharan Africa. Oral pre-exposure prophylaxis (PrEP) offers an effective HIV prevention method. In many countries, however, accessing PrEP necessitates that AGYW visit their local health clinic, where they may face access challenges. Some countries have implemented youth-friendly services to reduce certain challenges in local health clinics, but barriers to access persist, including clinic stigma. However, evidence of clinic stigma toward AGYW, particularly with respect to PrEP service delivery, is still limited. This mixed methods study explores stigma toward AGYW seeking clinic services, in particular PrEP, from the perspective of both clinic staff (clinical and nonclinical) and AGYW who seek services at clinic sites in Tshwane province, South Africa. METHODS : Six focus group discussions were conducted with AGYW (43 total participants) and four with clinic staff (42 total participants) and triangulated with survey data with AGYW (n = 449) and clinic staff (n = 130). Thematic analysis was applied to the qualitative data and descriptive statistics were conducted with the survey data. RESULTS : Four common themes emerged across the qualitative and quantitative data and with both AGYW and clinic staff, although with varying degrees of resonance between these two groups. These themes included (1) clinic manifestations of stigma toward AGYW, (2) concerns about providing PrEP services for AGYW, (3) healthcare providers’ identity as mothers, and (4) privacy and breaches of confidentiality. An additional theme identified mainly in the AGYW data pertained to stigma and access to healthcare. CONCLUSION : Evidence is needed to inform strategies for addressing clinic stigma toward AGYW, with the goal of removing barriers to PrEP services for this group. While awareness has increased and progress has been achieved around the provision of comprehensive, youth-friendly sexual and reproductive health services, these programs need to be adapted for the specific concerns of young people seeking PrEP services. Our findings point to the four key areas noted above where programs seeking to address stigma toward AGYW in clinics can tailor their programming.The Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health.http://www.biomedcentral.com/bmcpublichealtham2023Medical Microbiolog