A Novel Route for Preparation of Hollow Carbon Nanospheres Without Introducing Template

A newly developed route for the synthesis of hollow carbon nanospheres without introducing template under hydrothermal conditions was reported. Hollow carbon nanospheres with the diameter of about 100 nm were synthesized using alginate as reagent only. Many instruments were applied to characterize the morphologies and structures of carbon hollow nanospheres, such as XRD, TEM, and Raman spectroscopy. The possible formation and growth mechanism of carbon hollow spheres were discussed on the basis of the investigation of reaction influence factors, such as temperature, time, and content. The findings would be useful for the synthesis of more materials with hollow structure and for the potential use in many aspects. The loading of SnO2on the surface of carbon hollow spheres was processed, and its PL property was also characterized

D-STEM: a Design led approach to STEM innovation

Advances in the Science, Technology, Engineering and Maths (STEM) disciplines offer opportunities for designers to propose and make products with advanced, enhanced and engineered properties and functionalities. In turn, these advanced characteristics are becoming increasingly necessary as resources become ever more strained through 21st century demands, such as ageing populations, connected communities, depleting raw materials, waste management and energy supply. We need to make things that are smarter, make our lives easier, better and simpler. The products of tomorrow need to do more with less. The issue is how to maximize the potential for exploiting opportunities offered by STEM developments and how best to enable designers to strengthen their position within the innovation ecosystem. As a society, we need designers able to navigate emerging developments from the STEM community to a level that enables understanding and knowledge of the new material properties, the skill set to facilitate absorption into the design ‘toolbox’ and the agility to identify, manage and contextualise innovation opportunities emerging from STEM developments. This paper proposes the blueprint for a new design led approach to STEM innovation that begins to redefine studio culture for the 21st Century

Modelling the effect of land use change on hydrological model parameters via linearized calibration method in the upstream of Huaihe River Basin, China

Conceptual rainfall–runoff models have become a basic tool for evaluating effects of land use/cover changes on the hydrologic processes in small-scale as well as large watersheds. The runoff-producing mechanism is influenced by land use/cover changes. In this study, we analysed the effect of land use change on hydrological model parameters by calibrating the model parameters of different time periods with different land use via a linearized calibration method. The parameter calibration of a conceptual model usually involves the construction of objective function and optimization methods for good performance of observed data. However, the objective function of the minimum-sum-squared error will introduce an unrelated optimum solution for the parameter calibration problem of a conceptual model, which belongs to a highly complex nonlinear system. Thus, a linearized parameter calibration method, which searches for the optimal value on a parameter surface, is presented, based on the analysis of the problems of the objective function of the minimum-sum-squared error. Firstly, an ideal model is shown that illustrates the efficiency and applicability of this method. Secondly, the novel method is demonstrated for solving the Xinanjiang daily model parameter calibration. Finally, 50 years of data are divided into 4 different periods for parameter comparison, through which the effects of land use/cover changes on runoff in Dapoling watershed are evaluated. The results show that the linearized parameter calibration method is convergent, reasonable and effective. For example, the model parameter of evapotranspiration coefficient KC varied considerably, from 0.658 to 0.922, in response to land use/cover change within the watershed.Keywords: land use/cover change; parameter calibration; linearized; upper Huaihe River Basi

Advances in understanding of health-promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics

The health-promoting benefits of medicine and food homology (MFH) are known for thousands of years in China. However, active compounds and biological mechanisms are unclear, greatly limiting clinical practice of MFH. The advent of gut microbiota analysis and metabolomics emerge as key tools to discover functional compounds, therapeutic targets, and mechanisms of benefits of MFH. Such studies hold great promise to promote and optimize functional efficacy and development of MFH-based products, for example, foods for daily dietary supplements or for special medical purposes. In this review, we summarized pharmacological effects of 109 species of MFH approved by the Health and Fitness Commission in 2015. Recent studies applying genome sequencing of gut microbiota and metabolomics to explain the activity of MFH in prevention and management of health consequences were extensively reviewed. We discussed the potentiality in future to decipher functional activities of MFH by applying metabolomics-based polypharmacokinetic strategy and multiomics technologies. The needs for personalized MFH recommendations and comprehensive databases have also been highlighted. This review emphasizes current achievements and challenges of the analysis of gut microbiota and metabolomics as a new avenue to understand MFH

Roll coated large area ITO- and vacuum-free all organic solar cells from diketopyrrolopyrrole based non-fullerene acceptors with molecular geometry effects

In this paper, we investigate three diketopyrrolopyrrole (DPP) based small molecular non-fullerene acceptors, namely Ph(DPP)₃, Ph(DPP)₂, and PhDMe(DPP)₂, focusing on molecular geometry effects on the frontier orbital level, light absorption, molecular configuration, electron mobility, thin film morphology, and photovoltaic performance of both spin-coated ITO based and roll coated large area, ITO- and vacuum-free organic solar cells (OSCs). For spin-coated devices based on P3HT as the donor polymer the solar cells gave power conversion efficiencies (PCEs) in the following order for (P3HT:PhDMe(DPP)₂, 0.65%) > (P3HT:Ph(DPP)₂, 0.48%) > (P3HT:Ph(DPP)₃, 0.31%). All devices present an open circuit voltage (V_oc) higher than 1.0 V. For the roll-coated devices, the PCEs were found to fall in another order and with lower values (P3HT:Ph(DPP)₃, 0.54%) > (P3HT:Ph(DPP)2, 0.43%) > (P3HT:PhDMe(DPP)₂, 0.04%) and the highest V_oc was 0.82 V. Our preliminary results highlight the influence of geometry, structure and processing on the performance of non-fullerene acceptors

Curdlan Prevents the Cognitive Deficits Induced by a High-Fat Diet in Mice via the Gut-Brain Axis

A high-fat (HF) diet is a major predisposing factor of neuroinflammation and cognitive deficits. Recently, changes in the gut microbiota have been associated with neuroinflammation and cognitive impairment, through the gut-brain axis. Curdlan, a bacterial polysaccharide widely used as food additive, has the potential to alter the composition of the microbiota and improve the gut-brain axis. However, the effects of curdlan against HF diet-induced neuroinflammation and cognitive decline have not been investigated. We aimed to evaluate the neuroprotective effect and mechanism of dietary curdlan supplementation against the obesity-associated cognitive decline observed in mice fed a HF diet. C57Bl/6J male mice were fed with either a control, HF, or HF with curdlan supplementation diets for 7 days (acute) or 15 weeks (chronic). We found that acute curdlan supplementation prevented the gut microbial composition shift induced by HF diet. Chronic curdlan supplementation prevented cognitive declines induced by HF diet. In addition, curdlan protected against the HF diet-induced abnormities in colonic permeability, hyperendotoxemia, and colonic inflammation. Furthermore, in the prefrontal cortex (PFC) and hippocampus, curdlan mitigated microgliosis, neuroinflammation, and synaptic impairments induced by a HF diet. Thus, curdlan-as a food additive and prebiotic-can prevent cognitive deficits induced by HF diet via the colon-brain axis

Molecular Engineered Hole-Extraction Materials to Enable Dopant-Free, Efficient p-i-n Perovskite Solar Cells

Two hole-extraction materials (HEMs), TPP-OMeTAD and TPP-SMeTAD, have been developed to facilitate the fabrication of efficient p-i-n perovskite solar cells (PVSCs). By replacing the oxygen atom on HEM with sulfur (from TPP-OMeTAD to TPP-SMeTAD), it effectively lowers the highest occupied molecular orbital of the molecule and provides stronger Pb-S interaction with perovskites, leading to efficient charge extraction and surface traps passivation. The TPP-SMeTAD-based PVSCs exhibit both improved photovoltaic performance and reduced hysteresis in p-i-n PVSCs over those based on TPP-OMeTAD. This work not only provides new insights on creating perovskite-HEM heterojunction but also helps in designing new HEM to enable efficient organic–inorganic hybrid PVSCs