123 research outputs found
Three Essays on Communicative Planning: From the Perspective of East Asians
Communicative planning aims to strengthen the inclusiveness of planning by shifting the paradigm from the perception that the public is considered an object affected by the planning process to an active participant. In modern society, where people\u27s values are more diverse, communicative planning can be an alternative way to reflect the opinions of people with diverse identities for decision-making. At the same time, however, it is criticized for its difficulty in universal application, particularly in non-Western countries. Scholars argue that since communicative planning theory is biased toward Anglo-Americans\u27 context, it requires a specific contextual condition.
In this background, this dissertation seeks to understand communicative planning in the East Asian context through various approaches. Specifically, the dissertation consists of three essays on communicative planning in the East Asian context from both theoretical and empirical perspectives. Considering the cultural uniqueness of non-white racial groups, this dissertation pays attention to East Asians, who have been marginalized in both communicative planning and, more broadly, the field of urban planning.
The first essay conducts a systematic literature review to look at the situated communicative planning theory and practices in three East Asian countries: China, South Korea, and Japan. The second essay provides an empirical examination of how the communicative planning process operates in East Asian countries, using South Korea as an example. This essay particularly focuses on the role of facework, which plays a crucial role in human relationships in East Asia. Using qualitative content analysis with official reports, news articles, and video recordings of the community forum, this essay reveals that facework complicates the attainment of the ideal conditions of communicative planning, but it facilitates a cooperative attitude among participants. The final essay explores the racial disparity of neighborhood associations from the perspective of East Asians in Portland, Oregon. Using the mixed method approach, this essay shows that East Asian Portlanders are underrepresented in neighborhood associations, even though Asians are the second most populous racial group in Portland. Additionally, this essay identifies a significant barrier to initial participation: the mismatch between the characteristics of neighborhood associations and those of East Asian Portlanders
Fifteen Years After the Gozan-Dong Glass Fiber Outbreak, Incheon in 1995
Objectives: In 1995, an outbreak survey in Gozan-dong concluded that an association between fiberglass exposure in drinking water and cancer outbreak cannot be established. This study follows the subjects from a study in 1995 using a data linkage method to examine whether an association existed. The authors will address the potential benefits and methodological issues following outbreak surveys using data linkage, particularly when informed consent is absent. Methods: This is a follow-up study of 697 (30 exposed) individuals out of the original 888 (31 exposed) participants (78.5%) from 1995 to 2007 assessing the cancer outcomes and deaths of these individuals. The National Cancer Registry (KNCR) and death certificate data were linked using the ID numbers of the participants. The standardized incidence ratio (SIR) and standardized mortality ratio (SMR) from cancers were calculated by the KNCR. Results: The SIR values for all cancer or gastrointestinal cancer (GI) occurrences were the lowest in the exposed group (SIR, 0.73; 95% CI, 0.10 to 5.21; 0.00 for GI), while the two control groups (control 1: external, control 2: internal) showed slight increases in their SIR values (SIR, 1.18 and 1.27 for all cancers; 1.62 and 1.46 for GI). All lacked statistical significance. All-cause mortality levels for the three groups showed the same pattern (SMR 0.37, 1.29, and 1.11). Conclusions: This study did not refute a finding of non-association with a 13-year follow-up. Considering that many outbreak surveys are associated with a small sample size and a cross-sectional design, follow-up studies that utilize data linkage should become standard procedure.OAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000040632/15SEQ:15PERF_CD:SNU2011-01EVAL_ITEM_CD:102USER_ID:0000040632ADJUST_YN:YEMP_ID:A077602DEPT_CD:902CITE_RATE:0FILENAME:fifteen years after the gozan-dong glass fiber outbreak, incheon in 1995..pdfDEPT_NM:보건학과CONFIRM:
Liquid biopsy in lung cancer: Clinical applications of circulating biomarkers (CTCs and ctDNA)
Lung cancer is by far the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Recent advances in the understanding of the biology of tumors and in highly sensitive detection technologies for molecular analysis offer targeted therapies, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. However, our understanding of an individual patient's lung cancer is often limited by tumor accessibility because of the high risk and invasive nature of current tissue biopsy procedures. Liquid biopsy, the analysis of circulating biomarkers from peripheral blood, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), offers a new source of cancer-derived materials that may reflect the status of the disease better and thereby contribute to more personalized treatment. In this review, we examined the clinical significance and uniqueness of CTCs and ctDNA from NSCLC patients, isolation and detection methods developed to analyze each type of circulating biomarker, and examples of clinical studies of potential applications for early diagnosis, prognosis, treatment monitoring, and prediction of resistance to therapy. We also discuss challenges that remain to be addressed before such tools are implemented for routine use in clinical settings
A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC
Rationale: Unlike traditional biopsy, liquid biopsy, which is a largely non-invasive diagnostic and monitoring tool, can be performed more frequently to better track tumors and mutations over time and to validate the efficiency of a cancer treatment. Circulating tumor cells (CTCs) are considered promising liquid biopsy biomarkers; however, their use in clinical settings is limited by high costs and a low throughput of standard platforms for CTC enumeration and analysis. In this study, we used a label-free, high-throughput method for CTC isolation directly from whole blood of patients using a standalone, clinical setting-friendly platform. Methods: A CTC-based liquid biopsy approach was used to examine the efficacy of therapy and emergent drug resistance via longitudinal monitoring of CTC counts, DNA mutations, and single-cell-level gene expression in a prospective cohort of 40 patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer. Results: The change ratio of the CTC counts was associated with tumor response, detected by CT scan, while the baseline CTC counts did not show association with progression-free survival or overall survival. We achieved a 100% concordance rate for the detection of EGFR mutation, including emergence of T790M, between tumor tissue and CTCs. More importantly, our data revealed the importance of the analysis of the epithelial/mesenchymal signature of individual pretreatment CTCs to predict drug responsiveness in patients. Conclusion: The fluid-assisted separation technology disc platform enables serial monitoring of CTC counts, DNA mutations, as well as unbiased molecular characterization of individual CTCs associated with tumor progression during targeted therapy
Full Count of Eviction Cases Filed in Oregon Available for the First Time
Residential eviction cases can be filed in two court types in Oregon, circuit courts and justice courts. Up until now, statewide research on evictions has only included filings in circuit courts, because those court records are accessible through a centralized online database run by the judicial department. Eviction cases can be filed in fourteen justice courts in Oregon. Because each justice court maintains their court’s records onsite, these eviction cases have previously been invisible to researchers and policymakers. This study reports the first-ever full accounting of the number of eviction cases filed in Oregon, including cases filed in both court systems
Soft X-ray absorption spectroscopy study of spin crossover Fe-compounds: Persistent high spin configurations under soft X-ray irradiation
Metal-organic complex exhibiting spin crossover (SCO) behavior has drawn attention for its functionality as a nanoscale spin switch. The spin states in the metal ions can be tuned by external stimuli such as temperature or light. This article demonstrates a soft X-ray?induced excited spin state trapping (SOXEISST) effect in Hofmann-like SCO coordination polymers of FeII (4-methylpyrimidine)2 [Au(CN)2 ]2 and FeII (pyridine)2 [Ni(CN)4 ]. A soft X-ray absorption spectroscopy (XAS) study on these polymers showed that the high spin configuration (HS; S = 2) was prevalent in Fe2+ ions during the measurement even at temperatures much lower than the critical temperatures (>170 K), manifesting HS trapping due to the X-ray irradiation. This is in strong contrast to the normal SCO behavior observed in FeII (1,10-phenanthroline)2 (NCS)2, implying that the structure of the ligand chains in the polymers with relatively loose Fe-N coordination might allow a structural adaptation to stabilize the metastable HS state under the soft X-ray irradiation. (C) 2018 by the authors. Licensee MDPI, Basel, Switzerlan
Evicted in Oregon: County Eviction Profiles (2022-2023)
Eviction filings, case outcomes, and court procedures vary widely across the state. Housing markets, demographics, and available programs and services differ, resulting in variable patterns of housing instability due to eviction. Eviction cases in Oregon are processed through county-level circuit court and justice court systems, and significant variation in procedures and outcomes can occur. To capture some of this county-level variation - and to provide a resource for local organizers and policymakers - we created a series of ten County Eviction Profiles. Each profile includes information on county demographics, rental housing, eviction filings, the causes listed on termination notices, disparities in legal representation, and eviction case outcomes
Circulating Tumor Cells Enumerated by a Centrifugal Microfluidic Device as a Predictive Marker for Monitoring Ovarian Cancer Treatment: A Pilot Study
We investigated the size-based isolation and enumeration of circulating tumor cells (CTCs) using a centrifugal microfluidic device equipped with a fluid-assisted separation technology (FAST) disc. We further assessed the correlations among CTCs, cancer antigen-125 (CA125) levels, and clinical course of the disease in a prospective analysis of 47 serial blood samples collected at multiple time-points from 13 ovarian cancer patients. CTCs were isolated from whole blood using the FAST disc and were classified as epithelial cell adhesion molecule (EpCAM)/cytokeratin+, CD45-, and 4 ',6-diamidino-2-phenylindole (DAPI)+. Mean CTC count at baseline was 20.2; 84.62% of patients had more than one CTC at baseline and had decreased CTCs counts after surgery and chemotherapy. The CTC counts in eight patients with complete responses were <3. CTC counts were correlated with CA125 levels in three patients without recurrence; they were elevated in three patients with recurrence and normal CA125 concentrations. CTC counts and CA125 levels showed high concordance with directional changes (increasing 71.4%; non-increasing 75.0%). CTC counts showed higher associations with clinical status, sensitivity (100.0% vs. 60.0%), positive predictive value (55.6% vs. 42.9%), and negative predictive value (100.0% vs. 87.5%) than CA125 levels. CTC counts were better associated with treatment response and recurrence than CA125 levels
Unilateral Psoriasis in a Woman with Ipsilateral Post-Mastectomy Lymphedema
Psoriasis is a multi-factorial disease with various clinical manifestations. We present a case of unilateral psoriasis associated with ipsilateral lymphedema that developed after mastectomy for breast cancer. A 42-year-old Korean woman was referred to our clinic with a 1-month history of multiple erythematous scaly patches on the right arm, back, and breast and was diagnosed with psoriasis by a skin biopsy. Three years previously, she had been diagnosed with breast cancer (T1N2), underwent a right quadrantectomy and axillary lymph node dissection, and completed adjuvant chemotherapy followed by high-dose adjuvant radiotherapy. She had started rehabilitation therapy on the right arm for secondary lymphedema 30 months previously. Because of the long interval between radiation and psoriasis, we speculated that changes in the local milieu caused by the lymphedema might be a causative factor. We hereby report a rare case of unilateral psoriasis following post-mastectomy lymphedema
Comparative Studies of Different Imputation Methods for Recovering Streamflow Observation
Faulty field sensors cause unreliability in the observed data that needed to calibrate and assess hydrology models. However, it is illogical to ignore abnormal or missing values if there are limited data available. This study addressed this problem by applying data imputation to replace incorrect values and recover missing streamflow information in the dataset of the Samho gauging station at Taehwa River (TR), Korea from 2004 to 2006. Soil and Water Assessment Tool (SWAT) and two machine learning techniques, Artificial Neural Network (ANN) and Self Organizing Map (SOM), were employed to estimate streamflow using reasonable flow datasets of Samho station from 2004 to 2009. The machine learning models were generally better at capturing high flows, while SWAT was better at simulating low flows.open
- …