Populating middle kingdom fauna: Inclusion and exclusion of zoological iconographic motifs in its material culture

The first part of this article aims at discussing an ambiguous contextual synchronism between two categories of artefacts diagnostic of the Middle Kingdom material culture: miniatures made of faience and ivory tusks decorated with carved images. These two types of objects have often been paired together in Egyptological literature, as they were occasionally found in the same archaeological contexts, although their iconographic elements seem to be completely separate: the ivory tusks feature a fauna with particular ferocity and inclination to kill, while the faience figurines are more shifted towards domestic and harmless zoological specimens. The second part of the article aims at dissecting the mechanisms behind the inclusion and exclusion of their zoological (and human) iconographic elements. The fauna related to the ideology of the uppermost levels of society seem to have been almost systematically excluded from the faience figurine corpus, while their focus is arranged around the natural environment of marshes, swamps and farming. The author attempts to reconnect the environment of the faience figurines with a rural social setting, outlined in some literary and folk texts: the ‘Tale of the Herdsman’, ‘The Journey of the Libyan Goddess’, and pre-Islamic Berber tales about a being called the tamza (Islamic ghoul)

Profiling the people behind clay figurines: Technological trace and fingerprint analysis applied to ancient Egypt (Lahun village, MBA II, c. 1800–1700 BC)

Clay figurines represent one of the ideal object categories for tracing the profile of their makers since they preserve traces of the maker's gestures. The scope of the article is to reconstruct the different manufacturing steps of clay figurines, assess the complexity of the shaping sequences and study fingerprints to trace the profile of people who produced such artefacts in the ancient village of Lahun (Egypt, MBA II, c. 1800–1700 BC). The high number of production chains revealed that, despite an apparent roughness, clay figurine production was characterised by high stylistic and technological variability, indicating several levels of skill possessed by their producers. On this basis, Lahun clay figurines were not an extemporary or standardised product. A neat division can be established between anthropomorphic figurines and those representing animals, which show a lower degree of complexity and an attempt not to define clear shapes. Most of the figurines were revealed to be mainly shaped by adults, while children contributed in a marginal way to their production. However, the presence of sub-adult fingerprints on some of the clay figurines indicates that children were active agents producing material culture and integrating part of the adult production process through cooperation and/or playing

The Sheet Metal Figurines from Byblos: Evidence for an Egyptian Import and Adaptation

This paper considers some peculiar types of figurines found in Byblos, which are cut from a tiny, thin sheet of metal (copper alloy, silver, or gold). They represent human figures, mainly male, in a standing position. These figurines have been documented in various deposits in the acropolis of Byblos and their chronological range spans from 2100 to 1650 BC. Usually presented as a Gublite product, these figurines may actually be part of an Egyptian tradition, directly imported to Byblos and then developed and readapted locally. The evidence for an Egyptian import is provided by a foundation deposit discovered at Deir elBahri, in the mortuary complex of Montuhotep II (c. 2020 BC), which presents similar sheet metal figurines, but of clear Egyptian manufacture and conception

Childhood obesity and respiratory diseases: Which link?

Prevalence of childhood obesity is progressively increasing, reaching worldwide levels of 5.6% in girls and of 7.8% in boys. Several evidences showed that obesity is a major preventable risk factor and disease modifier of some respiratory conditions such as asthma and Obstructive Sleep Apnea Syndrome (OSAS). Co-occurrence of asthma and obesity may be due to common pathogenetic factors including exposure to air pollutants and tobacco smoking, Western diet, and low Vitamin D levels. Lung growth and dysanapsis phenomenon in asthmatic obese children play a role in impaired respiratory function which appears to be different than in adults. Genes involved in both asthma and obesity have been identified, though a gene-by-environment interaction has not been properly investigated yet. The identification of modifiable environmental factors influencing gene expression through epigenetic mechanisms may change the natural history of both diseases. Another important pediatric respiratory condition associated with obesity is Sleep-Disordered Breathing (SDB), especially Obstructive Sleep Apnea Syndrome (OSAS). OSAS and obesity are linked by a bidirectional causality, where the effects of one affect the other. The factors most involved in the association between OSAS and obesity are oxidative stress, systemic inflammation, and gut microbiota. In OSAS pathogenesis, obesity’s role appears to be mainly due to mechanical factors leading to an increase of respiratory work at night-time. However, a causal link between obesity-related inflammatory state and OSAS pathogenesis still needs to be properly confirmed. To prevent obesity and its complications, family education and precocious lifestyle changes are critical. A healthy diet may lead to an improved quality of life in obese children suffering from respiratory diseases. The present review aimed to investigate the links between obesity, asthma and OSAS, focusing on the available evidence and looking for future research fields

The predictive role of biomarkers and genetics in childhood asthma exacerbations

Asthma exacerbations are associated with significant childhood morbidity and mortality. Recurrent asthma attacks contribute to progressive loss of lung function and can sometimes be fatal or near‐fatal, even in mild asthma. Exacerbation prevention becomes a primary target in the management of all asthmatic patients. Our work reviews current advances on exacerbation predictive factors, focusing on the role of non‐invasive biomarkers and genetics in order to identify subjects at higher risk of asthma attacks. Easy‐to‐perform tests are necessary in children; therefore, interest has increased on samples like exhaled breath condensate, urine and saliva. The variability of biomarker levels suggests the use of seriate measurements and composite markers. Genetic predisposition to childhood asthma onset has been largely investigated. Recent studies highlighted the influence of single nucleotide polymorphisms even on exacerbation susceptibility, through involvement of both intrinsic mechanisms and gene‐environment interaction. The role of molecular and genetic aspects in exacerbation prediction supports an individual‐shaped approach, in which follow‐up planning and therapy optimization take into account not only the severity degree, but also the risk of recurrent exacerbations. Further efforts should be made to improve and validate the application of biomarkers and genomics in clinical settings

Evans Syndrome in Childhood: Long Term Follow-Up and the Evolution in Primary Immunodeficiency or Rheumatological Disease

Evans syndrome (ES) is a rare but challenging condition, characterized by recurrent and refractory cytopenia episodes. Recent discoveries highlighted that an appropriate diagnostic workup is fundamental to identify an underlying immune dysregulation such as primary immunodeficiencies or a rheumatological disease. We hereby describe clinical features and laboratory results of 12 pediatric patients affected by ES referred to the Pediatric Onco-Hematology Unit of Bologna. Patients experienced a median of four acute episodes of cytopenia with 9 years as median age at the onset of symptoms. In 8/12 (67%) patients an underlying etiology, primary immunodeficiencies, or rheumatological disease was identified. In 4/12 children, other immune manifestations were associated (Thyroiditis, Celiac disease, Psoriasis, Vitiligo, Myositis, Membranoproliferative Glomerulonephritis). ES remained the primary diagnosis in four patients (33%). At a median follow-up time of 4 years, 5/12 (42%) patients revealed a chronic ITP, partially responsive to second line therapy. Immunoglobulin Replacement Therapy (IRT) was effective with a good hematological values control in three patients with a secondary ES (ALPS, CVID, and a patient with Rubinstein Taybi Syndrome and a progressive severe B cell deficiency with hypogammaglobulinemia). Our experience highlights that, in pediatric patients, ES is often only the first manifestation of an immunological or rheumatological disease, especially when cytopenias are persistent or resistant to therapy, with an early-onset or when are associated with lymphadenopathy

Multilayered Inclusions in Locally Resonant Metamaterials: Two-Dimensional Versus Three-Dimensional Modeling

Locally resonant metamaterials (LRMs) controlling low-frequency waves due to resonant scattering are usually characterized by narrow band gaps (BGs) and a poor wave filtering performance. To remedy this shortcoming, multiresonant metamaterial structures with closely located BGs have been proposed and widely studied. However, the analysis is generally limited to two-dimensional (2D) structures neglecting the finite height of any real resonator. The aim of this paper is the comparison of the wave dispersion for two-and threedimensional (3D) metamaterial models and evaluation of the applicability ranges of 2D results. Numerical study reveals that dual-resonant structures with cylindrical inclusions possess only a single (compared to two in the 2D case) BG for certain height-to-width ratios. In contrast, the wave dispersion in metamaterials with multiple spherical resonators can be accurately evaluated using a 2D approximation, enabling a significant simplification of resource-consuming 3D models

Spin-orbit coupling in a hexagonal ring of pendula

journal_title: New Journal of Physics article_type: paper article_title: Spin–orbit coupling in a hexagonal ring of pendula copyright_information: © 2017 IOP Publishing Ltd and Deutsche Physikalische Gesellschaft license_information: cc-by Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. date_received: 2016-09-30 date_accepted: 2017-04-07 date_epub: 2017-05-1

Combined antiretroviral therapy reduces hyperimmunoglobulinemia in HIV-1 infected children

Objective: To evaluate the effect of combined antiretroviral therapy on serum immunoglobulin (Ig) levels in HIV-1 perinatally infected children. Methods: Data from 1250 children recorded by the Italian Register for HIV Infection in Children from 1985 to 2002 were analysed. Since Ig levels physiologically vary with age, differences at different age periods were evaluated as differences in z-scores calculated using means and standard deviations of normal population for each age period. Combined antiretroviral therapy has become widespread in Italy since 1996, thus differences in Ig z-scores between the periods 1985-1995 and 1996-2002 were analysed. Data according to type of therapeutic regimen were also analysed. Results: Between the two periods 1985-1995 and 1996-2002, significant (P < 0.0001) decreases in IgG (6.29 ± 4.72 versus 4.44 ± 4.33), IgM (9.25 ± 13.32 versus 5.61 ± 7.93), and IgA (10.25 ± 15.68 versus 6.48 ± 11.56) z-scores, together with a parallel significant (P < 0.0001) increase in CD4 T-lymphocyte percentages, were found. These decreases were confirmed regardless of whether the children were receiving intravenous Ig or not. Ig z-scores were significantly higher in children receiving mono-therapy than in those receiving double-combined therapy (IgC, P < 0.0001; IgM, P = 0.003; IgA, P = 0.031) and in the latter children than in those receiving three or more drugs (P < 0.0001 for all z-scores). Ig z-scores correlated inversely with CD4 T-lymphocyte percentages and, directly, with viral loads. Conclusions: Our data show that in HIV-1 infected children combined antiretroviral therapy leads to reduction of hyperimmunoglobulinemia which parallels restoration of CD4 T-lymphocyte percentage and viral load decrease, which it turn probably reflects improved B-lymphocyte functions. © 2004 Lippincott Williams & Wilkins