Expressing metaphorically, writing creatively: Metaphor identification for creativity assessment

Metaphor, which can implicitly express profound meanings and emotions, is a unique writing technique frequently used in human language. In writing, meaningful metaphorical expressions can enhance the literariness and creativity of texts. Therefore, the usage of metaphor is a significant impact factor when assessing the creativity and literariness of writing. However, little to no automatic writing assessment system considers metaphorical expressions when giving the score of creativity. For improving the accuracy of automatic writing assessment, this paper proposes a novel creativity assessment model that imports a token-level metaphor identification method to extract metaphors as the indicators for creativity scoring. The experimental results show that our model can accurately assess the creativity of different texts with precise metaphor identification. To the best of our knowledge, we are the first to apply automatic metaphor identification to assess writing creativity. Moreover, identifying features (e.g., metaphors) that influence writing creativity using computational approaches can offer fair and reliable assessment methods for educational settings

Metaphor research in the 21st century : a bibliographic analysis

Metaphor is widely used in human communication. The cohort of scholars studying metaphor in various fields is continuously growing, but very few work has been done in bibliographical analysis of metaphor research. This paper examines the advancements in metaphor research from 2000 to 2017. Using data retrieved from Microsoft Academic Graph and Web of Science, this paper makes a macro analysis of metaphor research, and expounds the underlying patterns of its development. Taking into consideration sub-fields of metaphor research, the internal analysis of metaphor research is carried out from a micro perspective to reveal the evolution of research topics and the inherent relationships among them. This paper provides novel insights into the current state of the art of metaphor research as well as future trends in this field, which may spark new research interests in metaphor from both linguistic and interdisciplinary perspectives. © 2020, ComSIS Consortium. All rights reserved

Protein-ligand binding representation learning from fine-grained interactions

The binding between proteins and ligands plays a crucial role in the realm of drug discovery. Previous deep learning approaches have shown promising results over traditional computationally intensive methods, but resulting in poor generalization due to limited supervised data. In this paper, we propose to learn protein-ligand binding representation in a self-supervised learning manner. Different from existing pre-training approaches which treat proteins and ligands individually, we emphasize to discern the intricate binding patterns from fine-grained interactions. Specifically, this self-supervised learning problem is formulated as a prediction of the conclusive binding complex structure given a pocket and ligand with a Transformer based interaction module, which naturally emulates the binding process. To ensure the representation of rich binding information, we introduce two pre-training tasks, i.e.~atomic pairwise distance map prediction and mask ligand reconstruction, which comprehensively model the fine-grained interactions from both structure and feature space. Extensive experiments have demonstrated the superiority of our method across various binding tasks, including protein-ligand affinity prediction, virtual screening and protein-ligand docking

SHOT-VAE: Semi-supervised Deep Generative Models With Label-aware ELBO Approximations

Semi-supervised variational autoencoders (VAEs) have obtained strong results, but have also encountered the challenge that good ELBO values do not always imply accurate inference results. In this paper, we investigate and propose two causes of this problem: (1) The ELBO objective cannot utilize the label information directly. (2) A bottleneck value exists and continuing to optimize ELBO after this value will not improve inference accuracy. On the basis of the experiment results, we propose SHOT-VAE to address these problems without introducing additional prior knowledge. The SHOT-VAE offers two contributions: (1) A new ELBO approximation named smooth-ELBO that integrates the label predictive loss into ELBO. (2) An approximation based on optimal interpolation that breaks the ELBO value bottleneck by reducing the margin between ELBO and the data likelihood. The SHOT-VAE achieves good performance with a 25.30% error rate on CIFAR-100 with 10k labels and reduces the error rate to 6.11% on CIFAR-10 with 4k labels.Comment: 12 pages, 6 figures, Accepted for presentation at AAAI202

Tetraspanin CO-029 Inhibits Colorectal Cancer Cell Movement by Deregulating Cell-Matrix and Cell-Cell Adhesions

Alterations in tetraspanin CO-029 expression are associated with the progression and metastasis of cancers in the digestive system. However, how CO-029 promotes cancer metastasis is still poorly understood. To determine the mechanism, we silenced CO-029 expression in HT29 colon cancer cells and found that the CO-029 knockdown significantly reduced cell migratory ability. The diminished cell migration was accompanied by the upregulation of both integrin-dependent cell-matrix adhesion on laminin and calcium-dependent cell-cell adhesion. The cell surface levels of laminin-binding integrin α3β1 and fibronectin-integrin α5β1 were increased while the level of CD44 was decreased upon CO-029 silencing. These changes contribute to the altered cell-matrix adhesion. The deregulated cell-cell adhesion results, at least partially, from increased activity of cadherins and reduced level of MelCAM. In conclusion, CO-029 functions as a regulator of both cell-matrix and cell-cell adhesion. During colon cancer progression, CO-029 promotes cancer cell movement by deregulating cell adhesions

Interactive Contrastive Learning for Self-supervised Entity Alignment

Self-supervised entity alignment (EA) aims to link equivalent entities across different knowledge graphs (KGs) without seed alignments. The current SOTA self-supervised EA method draws inspiration from contrastive learning, originally designed in computer vision based on instance discrimination and contrastive loss, and suffers from two shortcomings. Firstly, it puts unidirectional emphasis on pushing sampled negative entities far away rather than pulling positively aligned pairs close, as is done in the well-established supervised EA. Secondly, KGs contain rich side information (e.g., entity description), and how to effectively leverage those information has not been adequately investigated in self-supervised EA. In this paper, we propose an interactive contrastive learning model for self-supervised EA. The model encodes not only structures and semantics of entities (including entity name, entity description, and entity neighborhood), but also conducts cross-KG contrastive learning by building pseudo-aligned entity pairs. Experimental results show that our approach outperforms previous best self-supervised results by a large margin (over 9% average improvement) and performs on par with previous SOTA supervised counterparts, demonstrating the effectiveness of the interactive contrastive learning for self-supervised EA.Comment: Accepted by CIKM 202