INFERRING GENE NETWORKS FROM MICROARRAY WITH GRAPHICAL MODELS

ABSTRACT. Microarray technology allows to collect a large amount of genetic data, such as gene expression data. The activity of the genes are coordinate by a complex network that regulates their expressions controlling common functions, such as the formation of a transcriptional complex or the availability of a signalling pathway. Understanding this organization is crucial to explain normal cell physiology as well as to analyse complex pathological phenotypes. Graphical models are a class of statistical models that can be used to infer gene regulatory networks. In this paper, we examine a class of graphical models: the strongly decomposable graphical models for mixed variables. Among oth- ers properties, explicit expressions of maximum likelihood estimators are available for decomposable graphical models. This property makes the use of decomposable model suitable for high-dimensional data. We apply decomposable graphical models to a real dataset example

Faddeev calculation of pentaquark Θ+\Theta^+ in the Nambu-Jona-Lasinio model-based diquark picture

A Bethe-Salpeter-Faddeev (BSF) calculation is performed for the pentaquark $\Theta^+$ in the diquark picture of Jaffe and Wilczek in which $\Theta^+$ is a diquark-diquark-${\bar s}$ three-body system. Nambu-Jona-Lasinio (NJL) model is used to calculate the lowest order diagrams in the two-body scatterings of ${\bar s}D$ and $D D$. With the use of coupling constants determined from the meson sector, we find that ${\bar s}D$ interaction is attractive in s-wave while $DD$ interaction is repulsive in p-wave. With only the lowest three-body channel considered, we do not find a bound $\frac 12^+$ pentaquark state. Instead, a bound pentaquark $\Theta^+$ with $\frac 12^-$ is obtained with a unphysically strong vector mesonic coupling constants.Comment: 22 pages, 11 figures, accepted version in Phys. Rev. C. Summary of main changes/corrections: 1. "which only holds at tree level" below the eq. (23) is added. 2. In the last paragraph of p.23 we added a remark that the coupling constant obtained from Lambda mass is different from the estimate as obtained from the meson spectru

The complex time behaviour of the microquasar GRS 1915+105 in the \rho-class observed with BeppoSAX. III: The hard X-ray delay and limit cycle mapping

The microquasar GRS1915+105 was observed by BeppoSAX in October 2000 for about ten days while the source was in \rho-mode, which is characterized by a quasi-regular type I bursting activity. This paper presents a systematic analysis of the delay of the hard and soft X-ray emission at the burst peaks. The lag, also apparent from the comparison of the [1.7-3.4] keV light curves with those in the [6.8-10.2] keV range, is evaluated and studied as a function of time, spectral parameters, and flux. We apply the limit cycle mapping technique, using as independent variables the count rate and the mean photon rate. The results using this technique were also cross-checked using a more standard approach with the cross-correlation methods. Data are organized in runs, each relative to a continuous observation interval. The detected hard-soft delay changes in the course of the pointing from about 3 s to about 10 s and presents a clear correlation with the baseline count rate.Comment: accepted for publication in A&

Marketing strategy, social responsibility, and value chain in the agri-food system

The agri-food sector has changed significantly over the years, moving from a simple production system to a more and more industrialized one. For agents/operators involved in this sector, ensuring product quality and environmental externalities has become the key point to gaining a competitive advantage. In this context, corporate social responsibility (CSR) fits perfectly. This study analyzes the influence of CSR practices on the economic performance of a random sample of 130 agri-food companies in Italy. The results of an analysis of multiple linear regression models show that the economic performance (measured through value added and income) of agri-food enterprises seems to be influenced statistically by workplace CSR practices. Analysis of another model, during which we studied the relationship between income and the CSR practices (independent variables), highlights that operating results (economic performance) can be improved by CSR practices regarding the workplace, environment, and local community. Thus, empirical evidence shows that some CSR practices have positive effects on economic performance, with several implications for theory and practice

A BeppoSAX observation of the super-soft source CAL87

We report on a BeppoSAX Concentrator Spectrometer observation of the super-soft source (SSS) CAL87. The X-ray emission in SSS is believed to arise from nuclear burning of accreted material on the surface of a white dwarf (WD). An absorbed blackbody spectral model gives a chi^2_v of 1.18 and a temperature of 42 +/- ^13 _11 eV. However, the derived luminosity and radius are greater than the Eddington limit and radius of a WD. Including an O viii edge at 0.871 keV gives a significantly better fit (at > 95% confidence) and results in more realistic values of the source luminosity and radius. We also fit WD atmosphere models to the CAL87 spectrum. These also give reasonable bolometric luminosities and radii in the ranges 2.7-4.8 10^{36} erg/s and 8-20 10^7 cm, respectively. These results support the view that the X-ray emission from CAL87 results from nuclear burning in the atmosphere of a WD.Comment: 4 pages. Accepted for publication in A&A (Letters