Deep phenotyping and genomic data from a nationally representative study on dementia in India

The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is a nationally representative in-depth study of cognitive aging and dementia. We present a publicly available dataset of harmonized cognitive measures of 4,096 adults 60 years of age and older in India, collected across 18 states and union territories. Blood samples were obtained to carry out whole blood and serum-based assays. Results are included in a venous blood specimen datafile that can be linked to the Harmonized LASI-DAD dataset. A global screening array of 960 LASI-DAD respondents is also publicly available for download, in addition to neuroimaging data on 137 LASI-DAD participants. Altogether, these datasets provide comprehensive information on older adults in India that allow researchers to further understand risk factors associated with cognitive impairment and dementia.Peer reviewe

Cervical cancer: a tale from HPV infection to PARP inhibitors

Globally, cervical cancer (CxCa) ranks 4th common cancer among females and led to 569,847 incidences and 311,365 deaths in 2018. 80% of CxCa cases occur due to persistent infection with a high-risk subtype of human papillomavirus (HPV-16 and 18). Smoking, high parity, and co-infection with type 2 herpes simplex or HIV are other known risk factors for CxCa. Major histological subtypes are squamous (70%) and adenocarcinoma (25%). Presently, concurrent radiation plus cisplatin (CDDP)-based chemotherapy is the standard treatment for CxCa patients. However, CDDP resistance and toxic side effects limit its efficacy, leading to a poorer response rate and an expected overall survival ranging from 10 to 17.5 months. Reduced drug uptake, increased DNA damage repair, increased CDDP inactivation, and overexpressed Bcl-2 or caspase inhibition, are primarily accountable mechanisms for CDDP resistance and improving CDDP’s efficacy remains the major challenge. Poly (ADP-ribosyl) polymerase-1, an effective mediator of nucleotide excision repair pathway, is involved in DNA repair as well as maintaining genomic stability and is significantly expressed in malignant lymphomas, hepatocellular-, cervical- and colorectal carcinoma, which has been approved effective in maintenance therapy and may serve as an effective target to enhance CDDP sensitivity in CxCa. Here, we summarize the etiology and epidemiology of and treatment for CxCa, the mechanism responsible for chemotherapy resistance, PARP inhibitor as a possible therapy for CxCa, and other possible chemotherapeutic options for CxCa treatment

sj-docx-1-ggm-10.1177_23337214231194965 – Supplemental material for Association Between Cognitive Performance and Nutritional Status: Analysis From LASI-DAD

Supplemental material, sj-docx-1-ggm-10.1177_23337214231194965 for Association Between Cognitive Performance and Nutritional Status: Analysis From LASI-DAD by Manjusha Bhagwasia, Abhijith R. Rao, Joyita Banerjee, Swati Bajpai, Aruna V. Raman, Arunanshu Talukdar, Arvind Jain, Chhaya Rajguru, Lalit Sankhe, Debabrata Goswami, Ganapathy Sankaralingam Shanthi, Govind Kumar, Mathew Varghese, Minakshi Dhar, Monica Gupta, Parvaiz A-Koul, Rashmi Ranjan Mohanty, Sankha Shubhra Chakrabarti, Sathyanarayana Raju Yadati, Sharmistha Dey and Aparajit Ballav Dey in Gerontology and Geriatric Medicine</p