Weakening of the stratospheric polar vortex by Arctic sea-ice loss

Successive cold winters of severely low temperatures in recent years have had critical social and economic impacts on the mid-latitude continents in the Northern Hemisphere. Although these cold winters are thought to be partly driven by dramatic losses of Arctic sea-ice, the mechanism that links sea-ice loss to cold winters remains a subject of debate. Here, by conducting observational analyses and model experiments, we show how Arctic sea-ice loss and cold winters in extra-polar regions are dynamically connected through the polar stratosphere. We find that decreased sea-ice cover during early winter months (November-December), especially over the Barents-Kara seas, enhances the upward propagation of planetary-scale waves with wavenumbers of 1 and 2, subsequently weakening the stratospheric polar vortex in mid-winter (January-February). The weakened polar vortex preferentially induces a negative phase of Arctic Oscillation at the surface, resulting in low temperatures in mid-latitudes.open11167174Ysciescopu

Attributing northern high-latitude precipitation change over the period 1966–2005 to human influence

Using an optimal fingerprinting method and improved observations, we compare observed and CMIP5 model simulated annual, cold season and warm season (semi-annual) precipitation over northern high-latitude (north of 50A degrees N) land over 1966-2005. We find that the multi-model simulated responses to the effect of anthropogenic forcing or the effect of anthropogenic and natural forcing combined are consistent with observed changes. We also find that the influence of anthropogenic forcing may be separately detected from that of natural forcings, though the effect of natural forcing cannot be robustly detected. This study confirms our early finding that anthropogenic influence in high-latitude precipitation is detectable. However, in contrast with the previous study, the evidence now indicates that the models do not underestimated observed changes. The difference in the latter aspect is most likely due to improvement in the spatial-temporal coverage of the data used in this study, as well as the details of data processing procedures.111911Ysciescopu

Evaluating extreme rainfall changes over Taiwan using a standardized index

The annual daily maximum precipitation (rx1day) is widely used to represent extreme events and is an important parameter in climate change studies. However, the climate variability in rx1day is sensitive to outliers and has difficulty representing the characteristics of large areas. We propose to use the probability index (PI), based on the cumulative density function (CDF) of a generalized extreme value (GEV) distribution to fit and standardize the rx1day to represent extreme event records in this study. A good correlation between the area-averaged PIs of the observed stations and those of the gridded dataset can be found over Taiwan. From the past PI records, there is no distinct trend in western Taiwan before the end of the 20th century, but a climate regime change happened during 2002 - 2003. The dual change effects from both the variance and linear trend of extreme events are identified over the northeastern and southern parts of Taiwan, along with the island's central and southern regions, showing different abrupt changing trends and intensity. The PI can also be calculated using climate projection data to represent the characteristics of future extreme changes. The climate variability of PIs on the present (ALL) and future (RCP4.5 and RCP8.5) scenarios were evaluated using the 16 Couple Model Intercomparison Projects Phase-5 models (CMIP5). The simulated present fluctuations in PIs are smaller than those of actual observations. In the 21st century, the RCP8.5 scenario shows that the PI significantly increases by 10% during the first half of the century, and 14% by the end of the century.1112Ysciescopu

Electronic structures and magnetic properties of RB4 (R=Yb,Pr,Gd,Tb,Dy)

Most rare-earth tetraborides RB4 have antiferromagnetic ground states except for YbB4 and PrB4. We have investigated the electronic structures and magnetic properties of RB4 (R=Yb, Pr, Gd, Tb, Dy) employing the first-principles total energy band method. It is found that YbB4 has the paramagnetic ground state, while the other tetraborides are in the magnetic ground state, which is in agreement with experiments. We have obtained the spin and orbital magnetic moments and discussed the importance of the spin-orbit interaction and the on-site Coulomb repulsion (U) in these systems. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3058707]ope

Multi-model attribution of upper-ocean temperature changes using an isothermal approach

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In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease.

BackgroundLyme disease accounts for >90% of all vector-borne disease cases in the United States and affect ~300,000 persons annually in North America. Though traditional tetracycline antibiotic therapy is generally prescribed for Lyme disease, still 10%-20% of patients treated with current antibiotic therapy still show lingering symptoms.MethodsIn order to identify new drugs, we have evaluated four cephalosporins as a therapeutic alternative to commonly used antibiotics for the treatment of Lyme disease by using microdilution techniques like minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). We have determined the MIC and MBC of four drugs for three Borrelia burgdorferi s.s strains namely CA8, JLB31 and NP40. The binding studies were performed using in silico analysis.ResultsThe MIC order of the four drugs tested is cefoxitin (1.25 µM/mL) > cefamandole (2.5 µM/mL), > cefuroxime (5 µM/mL) > cefapirin (10 µM/mL). Among the drugs that are tested in this study using in vivo C3H/HeN mouse model, cefoxitin effectively kills B. burgdorferi. The in silico analysis revealed that all four cephalosporins studied binds effectively to B. burgdorferi proteins, SecA subunit penicillin-binding protein (PBP) and Outer surface protein E (OspE).ConclusionBased on the data obtained, cefoxitin has shown high efficacy killing B. burgdorferi at concentration of 1.25 µM/mL. In addition to it, cefoxitin cleared B. burgdorferi infection in C3H/HeN mice model at 20 mg/kg

The impact of the Southern Annular Mode on future changes in Southern Hemisphere rainfall

A robust positive trend in the Southern Annular Mode (SAM) is projected for the end of the 21st century under the Representative Concentration Pathway 8.5 scenario, which results in rainfall decreases in the midlatitudes and increases in the high latitudes in the Southern Hemisphere (SH). We find that this SAM trend also increases rainfall over the SH subtropics in austral summer but not in winter, leading to a pronounced wintertime poleward expansion of the subtropical dry zone. These dynamically driven rainfall changes by the SAM appear to oppose the thermodynamically driven projected rainfall changes in the SH subtropics and midlatitudes, whereas the two components reinforce each other in the high latitudes. However, we show that most climate models fall short in capturing the observed SAM component driven by the El Nino-Southern Oscillation and associated rainfall in the austral warm seasons, which limits our confidence in quantifying the contribution of the SAM to projected rainfall changes.11145Ysciescopu

Emergence of heat extremes attributable to anthropogenic influences

Climate scientists have demonstrated that a substantial fraction of the probability of numerous recent extreme events may be attributed to human-induced climate change. However, it is likely that for temperature extremes occurring over previous decades a fraction of their probability was attributable to anthropogenic influences. We identify the first record-breaking warm summers and years for which a discernible contribution can be attributed to human influence. We find a significant human contribution to the probability of record-breaking global temperature events as early as the 1930s. Since then, all the last 16 record-breaking hot years globally had an anthropogenic contribution to their probability of occurrence. Aerosol-induced cooling delays the timing of a significant human contribution to record-breaking events in some regions. Without human-induced climate change recent hot summers and years would be very unlikely to have occurred.111411Ysciescopu

Comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia

Tracheal extubation carries higher complication rates compared to intubation during general anaesthesia (GA). Thus, various drugs are used to attenuate hemodynamic responses and cough reflex during extubation. We investigated if intravenous (IV) lignocaine and esmolol, given prior extubation, was able to achieve that in hypertensive patients under GA. In this prospective, double-blinded, randomised controlled study, 68 hypertensive patients on treatment undergoing GA were analysed. Group L received IV lignocaine 1 mg/kg while Group E received IV esmolol 1.5 mg/kg, 2 minutes before extubation. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were recorded at the following interval: before study drug administration (T-0), prior extubation (T-1), 1 minute (T-2), 3 minutes (T-3), 5 minutes (T-4) and 10 minutes (T-5) post-extubation. Group L showed significantly increase in HR at T-2 while SBP and MAP increased significantly from T-1 until T-5. Group E showed a significant reduction in HR at T-1 up to T-5 and significantly lower HR at T-1 and T-2 compared to Group L. Group E showed stable SBP, DBP and MAP at all intervals. In conclusion, IV esmolol at 1.5 mg/kg was able to attenuate the hemodynamic response more pronounced when compared to IV lignocaine at 1 mg/kg from extubation stress in patients with hypertension on treatment. Both lignocaine and esmolol were equally effective in suppressing cough reflex during extubation

Factors associated with failed treatment : an analysis of 121,744 women embarking on their first IVF cycles

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