Development and characterization of nine polymorphic microsatellite markers in the seven-spotted lady beetle, Coccinella septempunctata (Coleoptera: Coccinellidae)

In this study, nine microsatellite loci were isolated and characterized from the seven-spotted lady beetle, Coccinella septempunctata (Coleoptera: Coccinellidae). The loci were validated and characterized using 20 samples collected from five Korean localities. These results indicate that some loci were highly variable in terms of number of alleles (2 to 13), heterozygosity (0.10 to 0.40), and polymorphic information content (0.31 to 0.85). These microsatellite markers will be very valuable for population genetic studies of C. septempunctata.Key words: Seven-spotted lady beetle, Coccinella septempunctata, microsatellite Deoxyribonucleic acid (DNA)

Deficits of case marker processing in persons with mild cognitive impairment

The purpose of the current study was to investigate whether persons with mild cognitive impairment (MCI) showed deficits in processing case markers compared to normal elderly adults (NEA). Results revealed that individuals with MCI presented significantly lower accuracy than the NEA group on a case marker processing (CMP) task. Both groups showed greater difficulties in the passive sentences than sentences with the transitive verbs. The current results suggested that individuals with early stage of dementia started presenting deficits in case marker processing compared to the control group

Designing Personalized Online Learning Environments for Adult Learners

2002Customizing instruction to meet individual needs is one of the foundational cornerstones of today's learner-centered paradigms. Adult learners have a wide range of differences in their backgrounds, interests, abilities, and learning styles; instruction, therefore, needs to be designed in such a way as to meet the highly diverse needs of adult education settings. The World Wide Web presents enormous potential for providing a technological environment for the optimal delivery of personalized instruction for individual learners. It is argued, however, that existing Web-based instruction fails to effectively customize instructions for individual learners. Therefore, we are in need of an ongoing refinement and creativity in our generation and treatment of theories of instruction geared towards the generation of personalized learning environments. Here, the attempt is made to develop an instructional-design theory for personalized online learning for online adult learners, with a special focus on the question of solving ill-structured problems. Theory, on a general level, is discussed insofar as it has emerged from the goals, preconditions, and underlying values, with an eye to the methods of instruction that are optimal for achieving the goals. The methods of instruction in this instructional-design theory are composed of four major components (goal-setting activities, engaging in the learning task, performing the task, and reviewing and reflecting upon the output of the task), with some corollaries detailing each major component. These methods incorporate the use of such Web technology as the learner management system, the learning objects system, and pedagogical agents to foster personalized learning process in online learning environments

Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Purpose The aim of this study was to describe the characteristics of epilepsy in cerebral palsy (CP) patients and identify risk factors for epilepsy and drug-resistant epilepsy. Methods CP patients aged 18 years old or younger who visited the pediatric neurology department and/or rehabilitation department of a tertiary care hospital between January 2016 and December 2022 with a minimum follow-up period of 2 years were included. Demographic and clinical data, seizure characteristics, brain imaging, electroencephalography, and genetic evaluation results were reviewed retrospectively. Results Among 268 patients included in this study, 36.9% had epilepsy and 10.8% had drug-resistant epilepsy. Asphyxia (29.3%), hemorrhage, infarction, and brain infection (25.3%) were associated with epilepsy. Epileptic CP patients were more likely to experience neonatal seizures (18.2% vs. 4.1%, P<0.001) and febrile seizures (12.1% vs. 7.1%, P=0.02) than non-epilepsy CP patients. The most common cerebral subtype in patients with epilepsy was spastic quadriplegia (59.6%). Epilepsy patients were more severely impaired in gross motor function, with worse intellectual disability. Patients with macrocephaly or cerebral malformation were more likely to have drug resistance. Valproate (51.7% and 25.7%) and levetiracetam (41.4% and 25.7%) were the two most commonly used antiseizure medications, both in monotherapy and polytherapy. Conclusion A history of asphyxia, febrile seizure, neonatal seizure, spastic quadriplegia, more severely impaired gross motor function, and intellectual disability were found to be risk factors for epilepsy. Further research with prospective data collection to develop a model for predicting seizures or epilepsy in CP patients is needed

Disparities in the utilisation of preventive health services by the employment status: an analysis of 2007-2012 South Korean national survey

Objectives This study aims to investigate the differences in the utilisation of preventive health services among standard, nonstandard workers, the self-employed, and unpaid family workers. Methods We used the 4th and 5th Korea National Health and Nutrition Examination Survey, a nationwide survey conducted from the year 2007 to 2012. Economically active workers between the ages of 25 and 64 were grouped into standard, nonstandard, the self-employed, and the unpaid family workers (N = 16,964). Outcome variables are the uptake of preventive health services including influenza vaccination, regular medical check-up, and four types of cancer screenings. We used multivariate logistic models. Results Overall, non-standard workers, the self-employed, and unpaid family workers were less likely to use the preventive health care compared to the standard workers. In particular, the selfemployed were less likely to use all the six services compared to the standard workers and showed the lowest level of uptakes among the four working groups. Moreover, the service uptake of the non-standard workers was lower than that of standard workers in all services; except the colon cancer screening. On the other hand, unpaid family workers showed mixed results. While the uptake of influenza vaccination and regular health screening were lower, participation to the cancer screening was not lower compared to that of standard workers. Conclusion There were gaps in the utilisation of preventive services among workers depending on their employment types. Access to preventive health care services of nonstandard workers, the self-employed, and unpaid family workers should be prioritised

Clinical characteristics of chronic rhinitis following stroke

BackgroundWe previously observed that patients with stroke complained of rhinitis symptoms that developed following the occurrence of stroke.ObjectivesTo investigate the relationship between chronic rhinitis (CR) and stroke.MethodsThis retrospective study analyzed the medical records and questionnaires of patients with stroke who visited our outpatient clinic from June to December 2020. Stroke lesions were mainly classified as supratentorial, infratentorial, and supra/infratentorial lesions. Supratentorial lesions were further divided into cortex, subcortex, and mixed. Participants were screened for CR and were subsequently divided into the CR and non-CR groups. The Sino-Nasal Outcome Test questionnaire and a questionnaire on autonomic nervous system symptoms were administered to all patients.ResultsClinically evaluated indicators were not significantly different between the two groups. The number of patients with lesions in both the cortex and subcortex was significantly higher in the CR group than in the non-CR group. The risk of CR was higher in male patients with stroke than their female counterparts; additionally, the risk of CR was higher in patients with stroke who had both cortical and subcortical lesions, as well as autonomic dysfunction.ConclusionsIndividuals with subcortical stroke damage had a greater probability of developing CR. The risk was increased in men, as compared with that in women, when autonomic symptoms were present