Tidal tilts observations in the Gran Sasso underground laboratory

A new tiltmeter, based on the technology for building a space-borne high-sensitivity accelerometer and manufactured at IFSI/CNR, has been operating during several years in the INFN Gran Sasso underground laboratory. The results of the analysis of a three-year data set, processed with the program package ETERNA, to estimate earthtidal parameters are reported. For the best series of data (1998) tide measurement accuracies are: 0.5–1% for the M2 (lunar principal) amplitude and 3–4% for the O1 (lunar declination) amplitude. The tiltmeter installed at a depth of 1400m shows no clear evidence of meteorological effects. Observed tidal parameters are compared with theoretical tidal parameters predicted for a non-hydrostatic inelastic Earth model and demonstrate good agreement for the M2 component. Due to the high accuracy of the tidal components prediction (better than 1%) tidal measurements were used to estimate the long-term stability of the instrument response

Experimental gravitation and geophysics

Seismic noise is the major obstacle to performing sensitive measurements of the gravitational field on the ground. The INFN (Istituto Nazionale di Fisica Nucleare) underground laboratory in Gran Sasso, L’Aquila(Italy), seems to be a favourable place from the environmental noise point of view. This paper describes briefly two, relatively low cost, gravity experiments that can be performed in the underground laboratory: a) A measurement of preferred-frame and preferred-location effects. b) A test of the equivalence principle. Preliminary experimental data of the seismic noise are also presented

Deep Sea Gravity Measurements: GEOSTAR-2 Mission Results

A new concept gravity meter with sensitivity close to Hz ms / 10 2 8 − − in the range of 10 -5 −1Hz intended for observation of the vertical component of the Earth gravity and teleseismic waves was implemented at the Istituto di Fisica dello Spazio Interplanetario (IFSI), CNR and successfully operated during the GEOSTAR-2 mission. The gravimeter has demonstrated a capability to operate for long time in an autonomous regime and a good reliability for operation in extreme environments; at the same time the experimental measurements gave the information for the further gravimeter’s implementation. Results of observation and data analysis included the registration of seismic waves excited by global earthquakes and the evaluation of the low frequency modes of free oscillations of the Earth are reported

Electrochemically driven molecular rotors based on ferrocene-1,1'-diyl-bisphosphinic acids

© 2015, Pleiades Publishing, Ltd. Based on ferrocene-1,1'-diyl-bisphosphinic acids Fc[P(R)(O)OH]2 (R = H, Me, Et, Ph) in methanol, two types of electrochemically driven molecular rotors are developed. Monoanions of acids are fixed in the cis-conformation due to the presence of an intramolecular hydrogen bond, whereas dianions are fixed in the trans-conformation due to electrostatic repulsion forces. Upon the transformation of monoanions to dianions, the controlled rotation of cyclopentadienyl rings from cis to trans-conformation occurs; the reverse switching leads to the reverse rotation. In one type of rotors, the rotation is controlled by the reversible variation of the solution pH and composition in the electrochemical oxidation-re-reduction cycle of N-phe-nyl-N'-isopropyl-1,4-phenylenediamine; in the other type, the rotation is determined by the one electron oxidation-re-reduction of the ferrocene nucleus in monoanions. The latter rotor type at room temperature can operate stably only for a short time (τ< 1 s) and at longer times is irreversibly destructed during the oxidation stage

Biological activity and pharmacological application of pectic polysaccharides: A review

© 2018 by the authors. Pectin is a polymer with a core of alternating a-1,4-linked D-galacturonic acid and α-1,2-L-rhamnose units, as well as a variety of neutral sugars such as arabinose, galactose, and lesser amounts of other sugars. Currently, native pectins have been compared to modified ones due to the development of natural medicines and health products. In this review, the results of a study of the bioactivity of pectic polysaccharides, including its various pharmacological applications, such as its immunoregulatory, anti-inflammatory, hypoglycemic, antibacterial, antioxidant and antitumor activities, have been summarized. The potential of pectins to contribute to the enhancement of drug delivery systems has been observed

ИНДИВИДУАЛЬНО-ТИПОЛОГИЧЕСКАЯ И СОЧЕТАННАЯ ИЗМЕНЧИВОСТЬ МОРФОЛОГИЧЕСКИХ ХАРАКТЕРИСТИК КОРОНАРНЫХ АРТЕРИЙ

Cardiovascular diseases are the leading cause of death and disability in the population in most developed countries. The organization of the vascular bed is an objective indicator of the state of the trophic tissue of any organ. The aim is to identify the individually-typological and concomitant variability of morphological characteristics of the coronary arteries in adults of the second period of mature and elderly. Materials and Methods: 161 coronary angiograms were investigated without evidence of pathological changes in coronary arteries of people of both sexes aged 36 to 74 years using the programs «Syngo Fast View», «ImageJ», «Adobe Photoshop CS7», «Microsoft Excel», «SPSS». Results: We identified the indivi-dually-typological and concomitant characteristics of the coronary arteries in people of different ages and sex in norm. Conclusions: Right and left coronary arteries have 3 types for the length of the main trunk (short, medium, long) and types of interposition of the branches of first order: 1 - compact (less than 47.420, less than 45.430), uniform (47.42 - 83.78; 45.43 -82.77), 3 - sparse (more than 83.78, 82.77 or more, respectively) depending on the angle between them (in diastole). Received data about anatomy of coronary arteries allows a more objective approach to the definition of tactics of treatment of cardiac patients.Главной причиной смерти и инвалидизации населения в большинстве стран мира являются заболевания сердца и сосудов. Состояние трофики тканей каждого органа определяется организацией сосудистого русла, что служит объективным критерием. Цель работы - определить индивидуально-типологическую и сочетанную изменчивость морфологических характеристик коронарных артерий взрослых людей второго периода зрелого и пожилого возраста. Исследованы коронароангиограммы 161 человека (мужчин и женщин в возрасте от 36 до 74 лет) без признаков патологических изменений коронарных артерий при помощи программ «Syngo Fast View», «ImageJ», «Adobe Photoshop CS7», «Microsoft Excel», «SPSS». Определены индивидуально-типологическая и сочетанная изменчивость морфологических характеристик коронарных артерий у людей различного возраста и пола в норме. Правая и левая коронарные артерии имеют 3 варианта по длине основного ствола (короткие, средние, длинные) и 3 варианта взаиморасположения ветвей первого порядка: 1 - компактное (менее 47,42о; менее 45,43о), 2 - равномерное (47,42-83,78о; 45,43-82,77о), 3 - разреженное (83,78о и более; 82,77о и более соответственно) в зависимости от угла между ними (в диастолу, в град.). Полученные данные расширяют сведения об анатомии коронарных артерий в норме

IR and UV study of reversible water-induced structural transformations of poly(manganese 1,1′-ferrocenediyl-bis(H-phosphinate)) and poly(cobalt 1,1′-ferrocenediyl-bis(H-phosphinate))

© 2018 Elsevier B.V. Recently new flexible and hydrolytically stable metal-organic framework [M(H2O)2(Fc(PHOO)2)·2H2O]n, M = Co has been synthesized by the use of synthetic technique, described earlier for M = Mn [1]. The heating of both complexes leads to elimination of water molecules and in the case of Co complex is accompanied by change of its color from orange to dark blue. The corresponding structural changes are reversible and are reflected in vibrational and electronic absorption spectra. Analysis of IR, Raman and UV–vis spectra of complexes shows the same structures of Mn and Co complexes before and after heating and suggests that both Mn and Co coordination polyhedra undergo reversible changes under heating from octahedral to tetrahedral form with ferrocene part remaining unchanged

Influence of the medium self-organization on the catalytic activity of palladium nanoparticles stabilized by amphiphilic phosphonium salts in the Suzuki reaction

© 2014 Springer Science+Business Media New York. The influence of the aggregation properties of the medium on the catalytic activity of palladium nanoparticles stabilized by amphiphilic phosphonium salts was demonstrated for the Suzuki coupling of bromoarenes and phenylboronic acid

ОЦЕНКА ВЛИЯНИЯ РАЗЛИЧНЫХ ПАРАМЕТРОВ РАДИОТЕРАПИИ НА РЕЗУЛЬТАТЫ ЛЕЧЕНИЯ ИНФИЛЬТРАТИВНЫХ ГЛИОМ ГОЛОВНОГО МОЗГА НИЗКОЙ СТЕПЕНИ ЗЛОКАЧЕСТВЕННОСТИ WHO GRADE II

The purpose of the study was to develop more effective fractionation regimens and radiation therapy programs in the treatment of infiltrative low-grade gliomas (WHO grade II). Material and methods. The study included 53 patients with morphologically verified supratentorial infiltrative low-grade gliomas (WHO grade II). Diffuse astrocytoma was diagnosed in 35 (66 %) patients, oligoastrocytoma in 7 (13 %) patients and oligodendroglioma in 11 (21 %) patients. Results. The overall survival (OS) was influenced by fractionated radiotherapy regimens (conventionally fractionated versus hypofractionated radiotherapy) (p=0.000) and type of radiotherapy (3D conformal versus 2D radiotherapy) (p=0.023). Multivariate analysis showed a statistically significant difference between the equivalent total dose (LQ-model) and OS (p=0.068). Risk factors proposed by the Association of Russian oncologists (р=0.947) and the extent of surgical excision (р=0.423) had no significant impact on the overall survival. Conclusion. Conventionally fractionated radiation therapy (2 Gy per fraction daily) significantly improved the OS compared to hypofractionated radiotherapy (3 Gy per fraction daily). The value of α/β ratio=6.8 Gy can be used to calculate the total dose using a linear-quadratic model.Цель исследования – разработка новых эффективных режимов фракционирования и программ радиотерапии, направленных на повышение эффективности результатов комбинированного лечения больных с супратенториальными инфильтративными глиомами низкой степени злокачественности WHO Grade II. Материал и методы. В исследование включены 53 пациента с морфологически верифицированной астроцитомой (66 %), олигодендроглиомой (21 %) и олигоастроцитомой (13 %) WHO Grade II головного мозга. Результаты. Статистически значимо влияли на показатели общей выживаемости (ОВ) такие параметры радиотерапии, как режим фракционирования (р=0,000) и методики радиотерапии (р=0,023). Уровень суммарной очаговой дозы (СОД) оказал влияние на показатели ОВ, близкие к статистически значимому (р=0,068). Группы прогноза, предложенные ассоциацией онкологов России (АОР) (р=0,947), и степень хирургической резекции (р=0,423) значимо не влияли на показатели ОВ. Заключение. Проведение радиотерапии в режиме гипофракционирования ухудшает результаты лечения по сравнению со стандартным режимом фракционирования. Значение α/β=6,8 Гр может быть использовано для расчета уровня СОД при помощи LQ-модели в клинической практике