591 research outputs found
Use of hydrophilic polymer coatings for control of electroosmosis and protein adsorption
The purpose of this project was to examine the utility of polyethylene glycol (PEG) and dextran coatings for control of electroosmosis and protein adsorption; electroosmosis is an important, deleterious process affecting electrophoretic separations, and protein adsorption is a factor which needs to be controlled during protein crystal growth to avoid multiple nucleation sites. Performance of the project required use of X-ray photoelectron spectroscopy to refine previously developed synthetic methods. The results of this spectroscopic examination are reported. Measurements of electroosmotic mobility of charged particles in appropriately coated capillaries reveals that a new, one-step route to coating capillaries gives a surface in which electroosmosis is dramatically reduced. Similarly, both PEG and dextran coatings were shown by protein adsorption measurements to be highly effective at reducing protein adsorption on solid surfaces. These results should have impact on future low-g electrophoretic and protein crystal growth experiments
Highly Non-Linear Optical (NLO) organic crystals
This research project involves the synthesis and characterization of organic materials having powerful nonlinear optical (NLO) properties and the growth of highly ordered crystals and monomolecular films of these materials. Research in four areas is discussed: theoretical design of new materials, characterization of NLO materials, synthesis of new materials and development of coupling procedures for forming layered films, and improvement of the techniques for vapor phase and solution phase growth of high quality organic crystals. Knowledge gained from these experiments will form the basis for experiments in the growth of these crystals
Physical properties of immiscible polymers
The demixing of immiscible polymers in low gravity is discussed. Applications of knowledge gained in this research will provide a better understanding of the role of phase segregation in determining the properties of polymer blends made from immiscible polymers. Knowledge will also be gained regarding the purification of biological materials by partitioning between the two liquid phases formed by solution of the polymers polyethylene glycol and dextran in water. Testing of new apparatus for space flight, extension of affinity phase partitioning, refinement of polymer chemistry, and demixing of isopycnic polymer phases in a one gravity environment are discussed
Casimir Force on a Micrometer Sphere in a Dip: Proposal of an Experiment
The attractive Casimir force acting on a micrometer-sphere suspended in a
spherical dip, close to the wall, is discussed. This setup is in principle
directly accessible to experiment. The sphere and the substrate are assumed to
be made of the same perfectly conducting material.Comment: 11 pages, 1 figure; to appear in J. Phys. A: Math. Ge
Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2
Ectopic expression in T-cell precursors of LIM only protein 2 (LMO2), a key factor in hematopoietic development, has been linked to the onset of T-cell acute lymphoblastic leukaemia (T-ALL). In the T-ALL context, LMO2 drives oncogenic progression through binding to erythroid-specific transcription factor SCL/TAL1 and sequestration of E-protein transcription factors, normally required for T-cell differentiation. A key requirement for the formation of this oncogenic protein-protein interaction (PPI) is the conformational flexibility of LMO2. Here we identify a small molecule inhibitor of the SCL-LMO2 PPI, which hinders the interaction in vitro through direct binding to LMO2. Biophysical analysis demonstrates that this inhibitor acts through a mechanism of conformational modulation of LMO2. Importantly, this work has led to the identification of a small molecule inhibitor of the SCL-LMO2 PPI, which can provide a starting point for the development of new agents for the treatment of T-ALL. These results suggest that similar approaches, based on the modulation of protein conformation by small molecules, might be used for therapeutic targeting of other oncogenic PPIs
Casimir effect for the scalar field under Robin boundary conditions: A functional integral approach
In this work we show how to define the action of a scalar field in a such a
way that Robin boundary condition is implemented dynamically, i.e., as a
consequence of the stationary action principle. We discuss the quantization of
that system via functional integration. Using this formalism, we derive an
expression for the Casimir energy of a massless scalar field under Robin
boundary conditions on a pair of parallel plates, characterized by constants
and . Some special cases are discussed; in particular, we show that
for some values of and the Casimir energy as a function of the
distance between the plates presents a minimum. We also discuss the
renormalization at one-loop order of the two-point Green function in the
theory submitted to Robin boundary condition on a plate.Comment: 16 pages, 2 figures. Version 2: contains a new section on the
renormalization of the two-point Green function in the presence of a flat
boundary. Accepted for publication in J. Phys.
Recommended from our members
Word frequency and trends in the development of French vocabulary in lower intermediate students during Year 12 in English schools
Scaling limits of a tagged particle in the exclusion process with variable diffusion coefficient
We prove a law of large numbers and a central limit theorem for a tagged
particle in a symmetric simple exclusion process in the one-dimensional lattice
with variable diffusion coefficient. The scaling limits are obtained from a
similar result for the current through -1/2 for a zero-range process with bond
disorder. For the CLT, we prove convergence to a fractional Brownian motion of
Hurst exponent 1/4.Comment: 9 page
One Loop Multiphoton Helicity Amplitudes
We use the solutions to the recursion relations for double-off-shell fermion
currents to compute helicity amplitudes for -photon scattering and
electron-positron annihilation to photons in the massless limit of QED. The
form of these solutions is simple enough to allow {\it all}\ of the
integrations to be performed explicitly. For -photon scattering, we find
that unless , the amplitudes for the helicity configurations (+++...+) and
(-++...+) vanish to one-loop order.Comment: 27 pages + 4 uuencoded figures (included), Fermilab-Pub-93/327-T,
RevTe
Colorado State University (CSU) accelerator and FEL facility
The Colorado State University (CSU) Accelerator Facility will include a 6-MeV L-Band (1.3 GHz) electron linear accelerator (linac) with a free-electron laser (FEL) system capable of producing Terahertz (THz) radiation, a laser laboratory, a microwave test laboratory, and a magnetic test laboratory. The photocathode-driven linac will be used in conjunction with a hybrid undulator capable of producing THz radiation. Here, a summary of the systems used at the CSU Accelerator Facility is discussed. The building construction is completed and equipment move-in has begun. The first beam is expected to occur by mid 2015
- …