3,629 research outputs found

    Radio Emission from GRO J1655-40 during the 1994 Jet Ejection Episodes

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    We report multifrequency radio observations of GRO J1655-40 obtained with the Australia Telescope Compact Array, the Molonglo Observatory Synthesis Telescope and the Hartebeesthoek Radio Astronomy Observatory at the time of the major hard X-ray and radio outbursts in 1994 August-September. The radio emission reached levels of the order of a few Jy and was found to be linearly polarized by up to 10%, indicating a synchrotron origin. The light curves are in good agreement with those measured with the VLA, but our closer time sampling has revealed two new short-lived events and significant deviations from a simple exponential decay. The polarization data show that the magnetic field is well ordered and aligned at right angles to the radio jets for most of the monitoring period. The time evolution of the polarization cannot be explained solely in terms of a simple synchrotron bubble model, and we invoke a hybrid `core-lobe' model with a core which contributes both synchrotron and free-free emission and `lobes' which are classical synchrotron emitters.Comment: 36 pages, 5 tables, 9 figures; accepted for publication in Ap

    Radio Supernova 1987A at 843 MHz

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    We report the flux densities of the evolving radio source SN1987A at 843 MHz measured from observations made with the Molonglo Observatory Synthesis Telescope between 1994 September and 2000 May. The radio light curve shows that the rate of increase of the flux density jumped markedly around days 2800-3000 (i.e. in the first half of 1995), and that since then the radio evolution has been remarkably well fitted by a simple linear increase of (62.7 +- 0.5) microJansky/day. We discuss in detail the relationship between the radio light curve and the recent brightening of the system at optical wavelengths.Comment: To be published in the Astrophysical Journal, 11 pages, 4 postscript figure

    On the making and taking of professionalism in the further education workplace

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    This paper examines the changing nature of professional practice in English further education. At a time when neo-liberal reform has significantly impacted on this under-researched and over-market-tested sector, little is known about who its practitioners are and how they construct meaning in their work. Sociological interest in the field has tended to focus on further education practitioners as either the subjects of market and managerial reform or as creative agents operating within the contradictions of audit and inspection cultures. In challenging such dualism, which is reflective of wider sociological thinking, the paper examines the ways in which agency and structure combine to produce a more transformative conception of the further education professional. The approach contrasts with a prevailing policy discourse that seeks to re-professionalise and modernise further education practice without interrogating either the terms of its professionalism or the neo-liberal practices in which it resides

    Self-diffusion in binary blends of cyclic and linear polymers

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    A lattice model is used to estimate the self-diffusivity of entangled cyclic and linear polymers in blends of varying compositions. To interpret simulation results, we suggest a minimal model based on the physical idea that constraints imposed on a cyclic polymer by infiltrating linear chains have to be released, before it can diffuse beyond a radius of gyration. Both, the simulation, and recently reported experimental data on entangled DNA solutions support the simple model over a wide range of blend compositions, concentrations, and molecular weights.Comment: 10 pages, 2 figure

    Estimating Individual and Household Reproduction Numbers in an Emerging Epidemic

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    Reproduction numbers, defined as averages of the number of people infected by a typical case, play a central role in tracking infectious disease outbreaks. The aim of this paper is to develop methods for estimating reproduction numbers which are simple enough that they could be applied with limited data or in real time during an outbreak. I present a new estimator for the individual reproduction number, which describes the state of the epidemic at a point in time rather than tracking individuals over time, and discuss some potential benefits. Then, to capture more of the detail that micro-simulations have shown is important in outbreak dynamics, I analyse a model of transmission within and between households, and develop a method to estimate the household reproduction number, defined as the number of households infected by each infected household. This method is validated by numerical simulations of the spread of influenza and measles using historical data, and estimates are obtained for would-be emerging epidemics of these viruses. I argue that the household reproduction number is useful in assessing the impact of measures that target the household for isolation, quarantine, vaccination or prophylactic treatment, and measures such as social distancing and school or workplace closures which limit between-household transmission, all of which play a key role in current thinking on future infectious disease mitigation

    Envelope Determinants of Equine Lentiviral Vaccine Protection

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    Lentiviral envelope (Env) antigenic variation and associated immune evasion present major obstacles to vaccine development. The concept that Env is a critical determinant for vaccine efficacy is well accepted, however defined correlates of protection associated with Env variation have yet to be determined. We reported an attenuated equine infectious anemia virus (EIAV) vaccine study that directly examined the effect of lentiviral Env sequence variation on vaccine efficacy. The study identified a significant, inverse, linear correlation between vaccine efficacy and increasing divergence of the challenge virus Env gp90 protein compared to the vaccine virus gp90. The report demonstrated approximately 100% protection of immunized ponies from disease after challenge by virus with a homologous gp90 (EV0), and roughly 40% protection against challenge by virus (EV13) with a gp90 13% divergent from the vaccine strain. In the current study we examine whether the protection observed when challenging with the EV0 strain could be conferred to animals via chimeric challenge viruses between the EV0 and EV13 strains, allowing for mapping of protection to specific Env sequences. Viruses containing the EV13 proviral backbone and selected domains of the EV0 gp90 were constructed and in vitro and in vivo infectivity examined. Vaccine efficacy studies indicated that homology between the vaccine strain gp90 and the N-terminus of the challenge strain gp90 was capable of inducing immunity that resulted in significantly lower levels of post-challenge virus and significantly delayed the onset of disease. However, a homologous N-terminal region alone inserted in the EV13 backbone could not impart the 100% protection observed with the EV0 strain. Data presented here denote the complicated and potentially contradictory relationship between in vitro virulence and in vivo pathogenicity. The study highlights the importance of structural conformation for immunogens and emphasizes the need for antibody binding, not neutralizing, assays that correlate with vaccine protection. © 2013 Craigo et al
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