Integrating prevention of mother to child HIV transmission competencies into the nursing curriculum: Methodological lessons from a university-based undergraduate programme

South Africa (SA) has the highest number of women infected with HIV and AIDS during pregnancy, which results in more than 70 000 infected babies being born each year AIDS is the major contributor to maternal and child morbidities and mortalities in the country. To combat this, the SA government has developed a national policy to prevent mother-to-child HIV transmission (PMTCT). However, for effective implementation of this policy, there is a dire need for a competent, skilled health worker to render the service. In response to this, the School of Nursing at the University of the Western Cape has integrated PMTCT competencies into the undergraduate Bachelor of Nursing Science curriculum. In this paper, we described teaching and learning approaches used to integrate PMTCT competencies, including the skills laboratory methodology and case-based learning, as well as a portfolio of evidence assessment tool. A quantitative descriptive design was used to analyse data collected from students in regard to assessment of PMTCT competencies achieved. The study used the conceptual framework of Lenburg’s competency outcomes and performance assessment model, which focuses on competency development and assessment in a clinical environment. HIV competencies, including PMTCT, should be integrated both theoretically and at service delivery into other nursing and midwifery competencies, including assessment strategies. Provincial policies in provision of antiretrovirals by nurses and midwives become barriers to successful implementation of PMTCT, resulting in limited learning opportunities for students to practice PMTCT competencies. Further research is required to assess an attribute, affect, which is another prong for competencies.Department of HE and Training approved lis

Program Pemberdayaan Desa (Studi Kasus Ued-sp Dharma Bakti Desa Gabung Makmur Kabupaten Siak)

Village Empowerment Program The program is aimed to review penangulangan Accelerate Poverty through Economic Empowerment UED-SP WITH provision Against Pemanfaat / or rural communities What do loans for a review of the business, Institutional Capacity and Empowerment AT village UED-SP. to review meujudkan Village Community Development The participatory and self-reliant. Of Research Singer substance is to determine the extent of development review UED-SP Dharma Bakti And The agency encourages empowerment hearts IN Village Community Economic businesses.Concept Theory The researchers use is empowerment Economic empowerment Institutional Capacity Productive And UED-SP Dharma Bakti. Methods used hearts singer research is qualitative descriptive WITH data collection instruments include Interview, Observation and Data Documents UED-SP Dharma Bakti.Research results show that the singer their taxable income through Empowerment Program Fund revolves UED-SP Dharma Bakti, the empowerment of society and Institutional capacity is increasing. ON refund arrears OR Loans Still experiencing congestion due to lack of training and mentoring Against USE Loan funds UED-SP Dharma Bakti. In addition to ITU, socioeconomic factors Pemanfaat The majority is Farmers, mostly oil, the price of palm fruit bunches (FFB) The fluaktif and social conditions laiinnya Opt Against Giving effect of economic business development Pemanfaat And Institutions UED-SP Dharma Bakti

Violent interaction between the AGN and the hot gas in the core of the galaxy cluster Sersic 159-03

We present a multi-wavelength study of the energetic interaction between the central active galactic nucleus (AGN), the intra-cluster medium, and the optical emission line nebula in the galaxy cluster Sersic 159-03. We use X-ray data from Chandra, high resolution X-ray spectra and UV images from XMM-Newton, Halpha images from the SOAR telescope, HST optical imaging, and VLA and GMRT radio data. The cluster center displays signs of powerful AGN feedback, which has cleared the central regions (r<7.5 kpc) of dense, X-ray emitting ICM. X-ray spectral maps reveal a high pressure ring surrounding the central AGN at a radius of r~15 kpc, indicating an AGN driven weak shock. The cluster harbors a bright, 44 kpc long Halpha+[NII] filament extending from the centre of the cD galaxy to the north. Along the filament, we see low entropy, high metallicity, cooling X-ray gas. The gas in the filament has most likely been uplifted by `radio mode' AGN activity and subsequently stripped from the galaxy due to its relative southward motion. Because this X-ray gas has been removed from the direct influence of the AGN jets, part of it cools and forms stars as indicated by the observed dust lanes, molecular and ionized emission line nebulae, and the excess UV emission.Comment: submitted to MNRA

A search for rapidly pulsating hot subdwarf stars in the GALEX survey

NASA's Galaxy Evolution Explorer (GALEX) provided near- and far-UV observations for approximately 77 percent of the sky over a ten-year period; however, the data reduction pipeline initially only released single NUV and FUV images to the community. The recently released Python module gPhoton changes this, allowing calibrated time-series aperture photometry to be extracted easily from the raw GALEX data set. Here we use gPhoton to generate light curves for all hot subdwarf B (sdB) stars that were observed by GALEX, with the intention of identifying short-period, p-mode pulsations. We find that the spacecraft's short visit durations, uneven gaps between visits, and dither pattern make the detection of hot subdwarf pulsations difficult. Nonetheless, we detect UV variations in four previously known pulsating targets and report their UV pulsation amplitudes and frequencies. Additionally, we find that several other sdB targets not previously known to vary show promising signals in their periodograms. Using optical follow-up photometry with the Skynet Robotic Telescope Network, we confirm p-mode pulsations in one of these targets, LAMOST J082517.99+113106.3, and report it as the most recent addition to the sdBVr class of variable stars.Comment: 11 Pages, 8 Figures, Accepted for publication in the Astrophysical Journa

Level of evidence used in recommendations by the National Comprehensive Cancer Network (NCCN) guidelines beyond Food and Drug Administration approvals.

BackgroundA previous analysis of 113 National Comprehensive Cancer Network® (NCCN®) recommendations reported that NCCN frequently recommends beyond Food and Drug Administration (FDA)-approved indications (44 off-label recommendations) and claimed that the evidence for these recommendations was weak.MethodsIn order to determine the strength of the evidence, we carried out an in-depth re-analysis of the 44 off-label recommendations listed in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®).ResultsOf the 44 off-label recommendations, 14 were later approved by the FDA and/or are supported by randomized controlled trial (RCT) data. In addition, 13 recommendations were either very minor extrapolations from the FDA label (n = 8) or were actually on-label (n = 5). Of the 17 remaining extrapolations, 8 were for mechanism-based agents applied in rare cancers or subsets with few available treatment options (median response rate = 43%), 7 were based on non-RCT data showing significant efficacy (&gt;50% response rates), and 2 were later removed from the NCCN Guidelines because newer therapies with better activity and/or safety became available.ConclusionOff-label drug use is a frequent component of care for patients with cancer in the United States. Our findings indicate that when the NCCN recommends beyond the FDA-approved indications, the strength of the evidence supporting such recommendations is robust, with a significant subset of these drugs later becoming FDA approved or supported by RCT. Recommendations without RCT data are often for mechanism-based drugs with high response rates in rare cancers or subsets without effective therapies

Investigation of phase-separated electronic states in 1.5µm GaInNAs/GaAs heterostructures by optical spectroscopy

We report on the comparative electronic state characteristics of particular GaInNAs/GaAs quantum well structures that emit near 1.3 and 1.5 µm wavelength at room temperature. While the electronic structure of the 1.3 µm sample is consistent with a standard quantum well, the 1.5 µm sample demonstrate quite different characteristics. By using photoluminescence sPLd excitation spectroscopy at various detection wavelengths, we demonstrate that the macroscopic electronic states in the 1.5 µm structures originate from phase-separated quantum dots instead of quantum wells. PL measurements with spectrally selective excitation provide further evidence for the existence of composition-separated phases. The evidence is consistent with phase segregation during the growth leading to two phases, one with high In and N content which accounts for the efficient low energy 1.5 µm emission, and the other one having lower In and N content which contributes metastable states and only emits under excitation in a particular wavelength range

The gas electron multiplier (GEM)

We describe operating priciples and results obtained with a new detector component: the Gas Electrons Multiplier (GEM). Consisting of a thin composite sheet with two metal layers separated by a thin insulator, and pierced by a regular matrix of open channels, the GEM electrode, inserted on the path of electrons in a gas detector, allows to transfer the charge with an amplification factor approaching ten. Uniform response and high rate capability are demonstrated. Coupled to another device, multiwire or micro-strip chamber, the GEM electrode permit to obtain higher gains or less critical operation; separation of the sensitive (conversion) volume and the detection volume has other advantages, as a built-in delay (useful for triggering purposes) and the possibility of applying high fields on the photo-cathode of ring imaging detectors to improve efficiency. Multiple GEM grids in the same gas volume allow to obtain large amplification factors in a succession of steps, leading to the realization of an effective gas-filled photomultiplier