3,770 research outputs found

    Hair Today, Gone Tomorrow: Upsherin, Alef-Bet, and the Childhood Navigation of Jewish Gender Identity Symbol Sets

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    In this essay, I introduce the theoretical framework of hairlore, discussing its challenges when applied to the hair of infants and very young children. I contextualize the ritual of upsherin, reviewing its history, describing contemporary applications, and discussing variations of the practice. Finally, I offer an analysis of upsherin, considering its role in the shifting relationship between mother and son, as well as in the maintenance of a gendered Orthodox symbol set, and discuss the possibility of egalitarian parallels for young girls. I ultimately argue that upsherin is ripe for adaptation by liberal Jewish communities in its celebration of Jewish core values

    Bodylore and Dress

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    Bodylore includes the ways in which the body is used as a canvas for inherited and chosen identity. Bodylore considers the symbolic inventory of dress and hair, addressing a range of identities from conservative religious groups like the Amish and the Hasidim to edgy goth and punk devotees. The body is scripted in portrayals of race, ethnicity, gender, age, religion, and politics, including such topics as tattoos, piercing, scarification, hair covering and styling, traditional and folk dress, fashion, and body modification. The central bodylore questions are whether individuals choose consciously or subconsciously to engage with their performative body, as well as why the body is often overlooked as a text within academic studies. This essay identifies the body as a malleable folkloric space, allowing for its symbols to function in both personal and public ways

    Seasonal Malaria Chemoprevention Coverage Survey Guinea, 2017

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    A review of integrated surveys for resource inventory and monitoring of pastoral production systems in sub-Saharan Africa

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    Reviews various approaches and techniques used in a number of sub-Saharan African countries to collect and analyze data on large-scale ecological changes with particular reference to remote sensing and monitoring techniques in resource inventory; suggests ways to build more effective data bases

    Integration of remote sensing techniques for resource evaluation in pastoral systems research

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    Reviews most recent applications of methodologies for resource surveys appropriate to pastoral & agro-pastoral regions in Africa, with particular reference to remote sensing methodologies, viz. satellite imagery, aerial photography, side-looking radar (SLR), spectral radiance and low-altitutde aerial survey. Discusses the integration of remote sensing techniques with ground truth within the context of rapid appraisal methods and early warning procedures within a livestock systems research approach

    Tsetse, trypanosomiasis and cattle in a changing environment

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    Identifies interrelationships between modifications of the environment and the growth of Nigeria's population and consequent agricultural expansion in the subhumid zone resulting in the disappearance of habitats & hosts of tsetse. Discusses impacts of these changes in the distribution of the national cattle herd, particularly in relation to incidence of tsetse & trypanosomiasis

    Development and characterization of a fluorescent tracer for the free fatty acid receptor 2 (FFA2/GPR43)

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    The free fatty acid receptor 2 (FFA2/GPR43) is considered a potential target for treatment of metabolic and inflammatory diseases. Here we describe the development of the first fluorescent tracer for FFA2 intended as a tool for assessment of thermodynamic and kinetic binding parameters of unlabeled ligands. Starting with a known azetidine FFA2 antagonist, we used a carboxylic acid moiety known not to be critical for receptor interaction as attachment point for a nitrobenzoxadiazole (NBD) fluorophore. This led to the development of 4 (TUG-1609), a fluorescent tracer for FFA2 with favorable spectroscopic properties and high affinity, as determined by bioluminescence resonance energy transfer (BRET)-based saturation and kinetic binding experiments, as well as a high specific to nonspecific BRET binding signal. A BRET-based competition binding assay with 4 was also established and used to determine binding constants and kinetics of unlabeled ligands

    Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands

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    Short chain fatty acids (SCFAs) are produced in the gut by bacterial fermentation of poorly digested carbohydrates. A key mediator of their actions is the G protein-coupled Free Fatty Acid 2 (FFA2) receptor and this has been suggested as a therapeutic target for the treatment of both metabolic and inflammatory diseases. However, a lack of understanding of the molecular determinants dictating how ligands bind to this receptor has hindered development. We have developed a novel radiolabelled FFA2 antagonist in order to probe ligand binding to FFA2 and in combination with mutagenesis and molecular modelling studies define how agonist and antagonist ligands interact with the receptor. Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII of FFA2, there are clear differences in how these interactions occur. Specifically, while agonists require interaction with both arginine residues to bind the receptor, antagonists require an interaction with only one of the two. Moreover, different chemical series of antagonist interact preferentially with different arginine residues. A homology model capable of rationalizing these observations was developed and provides a tool that will be invaluable for identifying improved FFA2 agonists and antagonists to further define function and therapeutic opportunities of this receptor

    Thissavros Hydropower Plant Managing Geotechnical Problems in the Construction

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    The Thissavros hydropower and pumped storage project on the Nestos river in northern Greece involved construction of a 172 m high rockfill dam and an underground power house with 300 MW installed capacity. Bedrock at the site consists of gneiss with complex geological structure and complicated hydrogeological conditions. On the right abutment, the dam partially rests on a large landslide and the toe of another large landslide extends into the plunge pool from the left bank. Initial excavations activated the dormant slides. Unloading, buttressing and drainage successfully stabilized the landslides. Core material for the dam is a silty sand and required special precautions in design and construction. Starting with an extremely rapid reservoir filling the dam has performed highly satisfactorily. The power house had to be excavated in a relatively unfavorable geological orientation but application of structural discontinuity analysis avoided wedge failures
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