Acoustica's international expansion: The French market

This project consists of a market study. It holds as aim to identify if the selected country will be receptive to a foreign sound insulation offer. The opening section will be dedicated to discovering how badly France is affected by noise. General data will prove the seriousness of the issue in different environments. The global impact on the French population’ health, at their workspace and in transport. The following section will be an in-depth analysis of the internal aspects of the company. Thus, giving a wide spectre of their current business situation and their ability to take on such a project. Succeeding in the same section will be a market observation. Enabling the identification of France’s market potential and highlighting the local competition. Afterward will be the practical development plan, consisting of different export scenarios as well as key contacts to put forward the project. Ultimately, will be the recommendations and porter five forces. These two sections will provide a conclusive aspect to the project and help summarise if the company receives a green or red light for their exportation.Este projeto consiste em um estudo de mercado. Tem por objetivo identificar se o país selecionado será receptivo a uma oferta estrangeira de isolamento acústico. A seção de abertura será dedicada a descobrir como a França é afetada pelo ruído. Dados gerais comprovarão a gravidade do problema em diferentes ambientes. O impacto global na saúde da população francesa, em seu local de trabalho e nos transportes. A seção seguinte fará uma análise aprofundada dos aspectos internos da empresa. Assim, dando um amplo espectro de sua situação atual de negócios e sua capacidade de assumir tal projeto. O sucesso na mesma seção será uma observação do mercado. Permitindo a identificação do potencial de mercado da França e destacando a concorrência local. Posteriormente, estará o plano de desenvolvimento prático, consistindo em diferentes cenários de exportação, bem como os principais contatos para apresentar o projeto. Em última análise, serão as recomendações e cinco forças porter. Essas duas seções fornecerão um aspecto conclusivo do projeto e ajudarão a resumir se a empresa recebe sinal verde ou vermelho para sua exportação

Ice-Ocean Interactions in North West Greenland

Ice shelves play an important role in the mass balance of an ice sheet, by providing a link between the ocean and ice. Melting at the base of an ice shelf can play a vital role in its mass balance and stability. Topographic channel features have been found on the base of ice shelves, and have been found to alter melting, however the mechanism behind this alteration is unknown. Petermann Glacier is a major outlet glacier in North West Greenland, draining approximately 6% of Greenland Ice Sheet. It terminates in a long, thin ice shelf, constrained within a high-walled fjord. The ice shelf has pronounced longitudinal channel features on its base, which limited observations suggest direct ocean currents in a mixed layer of ocean and melt waters, focusing melt in these regions. Petermann Glacier underwent two large calving events in 2010 and 2012, and the impact of these events, or possible further calving events, on basal melting is unknown. Using the MITgcm to model the ocean cavity beneath an idealised ice shelf, this thesis discusses the impact of basal channels on interactions at the ice base and circulation within the cavity. This is supplemented with a modelling investigation into the interactions beneath Petermann Glacier, and the impact of recent calving events. The inclusion of channels was found to have a stabilising effect on the ice shelf by decreasing the mean basal melt rate, caused by the refocusing, and decrease in intensity of, the meltwater layer flow beneath the ice shelf. This stabilisation and resulting `survivor bias' explains why channels are commonly found on the base of warm water ice shelves. The model of Petermann Glacier found similar melt patterns to observational studies, however with a lesser magnitude. The calving events of 2010 and 2012 removed areas of ice shelf with low melt rates, resulting in little impact on the overall volume of ice removed through ocean melting, though further calving would vastly reduce the volume of ice melted. One consequence of calving is the increase in melting-induced undercutting at the ice front, leading to the potential for enhanced secondary calving. Part of the results contained within this thesis are published as: Millgate, T., P.R. Holland, A. Jenkins and H.L. Johnson (2013), The effect of basal channels on oceanic ice-shelf melting, Journal of Geophysical Research Oceans, 118, doi:10.1002/2013JC009402

Closure planning in a developing country - a case study from the Phu Kham Mine, Laos, Southeast Asia

Mining in developing regions face significant challenges for effective closure planning. A maturing mine closure regulatory environment and limited capacity within government to regulate mine closure issues can present considerable risk from an operation to the regional community and environment. Alternatively, if the operation adopts leading practice international standards in recognition of their corporate responsibilities and social license‐to‐mine in developing countries, there may be significant opportunities for enhanced social and environmental outcomes for host country and mining company. Using a case study from the Phu Kham Mine, Lao People’s Democratic Republic (Laos), we discuss some of the key challenges to closure planning, including the limitations of closure regulation and community capacity to assimilate closure issues, in a developing country. We describe how leading mine closure planning can be achieved in a developing country using leading practice international standards. The practical application of these standards is already leading to significant social outcomes in the areas of community development through initiatives targeting health, education and economic opportunities. When planning for closure, the focus must shift towards a longer term view, which endeavours to use the remaining years of the operation to prepare local communities for post‐mining independence and sustainable benefits. We highlight the potential for both social and environmental benefits post‐closure and the degree of planning required to get there

Neuropsychological differences between treatment-resistant and treatment-responsive schizophrenia:a meta-analysis

Antipsychotic treatment resistance affects up to a third of individuals with schizophrenia. Of those affected, 70–84% are reported to be treatment resistant from the outset. This raises the possibility that the neurobiological mechanisms of treatment resistance emerge before the onset of psychosis and have a neurodevelopmental origin. Neuropsychological investigations can offer important insights into the nature, origin and pathophysiology of treatment-resistant schizophrenia (TRS), but methodological limitations in a still emergent field of research have obscured the neuropsychological discriminability of TRS. We report on the first systematic review and meta-analysis to investigate neuropsychological differences between TRS patients and treatment-responsive controls across 17 published studies (1864 participants). Five meta-analyses were performed in relation to (1) executive function, (2) general cognitive function, (3) attention, working memory and processing speed, (4) verbal memory and learning, and (5) visual−spatial memory and learning. Small-to-moderate effect sizes emerged for all domains. Similarly to previous comparisons between unselected, drug-naïve and first-episode schizophrenia samples v. healthy controls in the literature, the largest effect size was observed in verbal memory and learning [dl = −0.53; 95% confidence interval (CI) −0.29 to −0.76; z = 4.42; p < 0.001]. A sub-analysis of language-related functions, extracted from across the primary domains, yielded a comparable effect size (dl = −0.53, 95% CI −0.82 to −0.23; z = 3.45; p < 0.001). Manipulating our sampling strategy to include or exclude samples selected for clozapine response did not affect the pattern of findings. Our findings are discussed in relation to possible aetiological contributions to TRS

A taxonomy of theory of mind measures and their relationship with alexithymia

Theory of Mind (ToM), the ability to represent the mental states of oneself and others, is an essential social skill disrupted across many psychiatric conditions. The transdiagnostic nature of ToM impairment means it is plausible that ToM impairment is related to alexithymia (difficulties identifying and describing one’s own emotions), as alexithymia is seen across psychiatric conditions. Whilst many studies have examined links between alexithymia and ToM, results are mixed. Therefore, the purpose of this systematic review is to provide a taxonomy of ToM tests and assess their relationship with alexithymia. Tests are grouped according to whether they assess propensity to engage spontaneously in ToM or accuracy of ToM inferences, with tests further subdivided into those that do, and do not, require emotion recognition. A review of 63 suitable studies suggests that alexithymia is often associated with reduced ToM, and inaccurate ToM when tasks require emotion recognition. This latter finding appears due to impaired emotion recognition, rather than ToM impairment per se. Further directions and considerations for future research are discussed

Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study

Background 70%–84% of individuals with antipsychotic treatment resistance show non-response from the first episode. Emerging cross-sectional evidence comparing cognitive profiles in treatment resistant schizophrenia to treatment-responsive schizophrenia has indicated that verbal memory and language functions may be more impaired in treatment resistance. We sought to confirm this finding by comparing cognitive performance between antipsychotic non-responders (NR) and responders (R) using a brief cognitive battery for schizophrenia, with a primary focus on verbal tasks compared against other measures of cognition. Design Cross-sectional. Setting This cross-sectional study recruited antipsychotic treatment R and antipsychotic NR across four UK sites. Cognitive performance was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS). Participants One hundred and six participants aged 18–65 years with a diagnosis of schizophrenia or schizophreniform disorder were recruited according to their treatment response, with 52 NR and 54 R cases. Outcomes Composite and subscale scores of cognitive performance on the BACS. Group (R vs NR) differences in cognitive scores were investigated using univariable and multivariable linear regressions adjusted for age, gender and illness duration. Results Univariable regression models observed no significant differences between R and NR groups on any measure of the BACS, including verbal memory (ß=−1.99, 95% CI −6.63 to 2.66, p=0.398) and verbal fluency (ß=1.23, 95% CI −2.46 to 4.91, p=0.510). This pattern of findings was consistent in multivariable models. Conclusions The lack of group difference in cognition in our sample is likely due to a lack of clinical distinction between our groups. Future investigations should aim to use machine learning methods using longitudinal first episode samples to identify responder subtypes within schizophrenia, and how cognitive factors may interact within this

Cognitive performance at first episode of psychosis and the relationship with future treatment resistance: Evidence from an international prospective cohort study

Background: Antipsychotic treatment resistance affects up to a third of individuals with schizophrenia, with recent research finding systematic biological differences between antipsychotic resistant and responsive patients. Our aim was to determine whether cognitive impairment at first episode significantly differs between future antipsychotic responders and resistant cases. Methods: Analysis of data from seven international cohorts of first-episode psychosis (FEP) with cognitive data at baseline (N = 683) and follow-up data on antipsychotic treatment response: 605 treatment responsive and 78 treatment resistant cases. Cognitive measures were grouped into seven cognitive domains based on the preexisting literature. We ran multiple imputation for missing data and used logistic regression to test for associations between cognitive performance at FEP and treatment resistant status at follow-up. Results: On average patients who were future classified as treatment resistant reported poorer performance across most cognitive domains at baseline. Univariate logistic regressions showed that antipsychotic treatment resistance cases had significantly poorer IQ/general cognitive functioning at FEP (OR = 0.70, p = .003). These findings remained significant after adjusting for additional variables in multivariable analyses (OR = 0.76, p = .049). Conclusions: Although replication in larger studies is required, it appears that deficits in IQ/general cognitive functioning at first episode are associated with future treatment resistance. Cognitive variables may be able to provide further insight into neurodevelopmental factors associated with treatment resistance or act as early predictors of treatment resistance, which could allow prompt identification of refractory illness and timely interventions.Funding: This work was supported by a Stratified Medicine Programme grant to J.H.M from the Medical Research Council (grant number MR/L011794/1 which funded the research and supported S.E.S., A.F.P., R.M.M., J.T.R.W. & J.H.M.) E.M’s PhD is funded by the MRC-doctoral training partnership studentship in Biomedical Sciences at King’s College London. J.H.M, E.K, R.M.M are part funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. A.P.K. is funded by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. O.A. is further funded by an NIHR Post-Doctoral Fellowship (PDF2018-11-ST2-020). The views expressed are those of the authors and not necessarily those of the NHS, the MRC, the NIHR or the Department of Health. E.M.J. is supported by the UCL/UCLH Biomedical Research Centre. The AESOP (London, UK) cohort was funded by the UK Medical Research Council (Ref: G0500817). The Bologna (Italy) cohort was funded by the European Community’s Seventh Framework Program under grant agreement (agreement No. HEALTH-F2-2010–241909, Project EU-GEI). The GAP (London, UK) cohort was funded by the UK National Institute of Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health, South London and Maudsley NHS Mental Health Foundation Trust (SLaM) and the Institute of Psychiatry, Psychology, and Neuroscience at King’s College London; Psychiatry Research Trust; Maudsley Charity Research Fund; and the European Community’s Seventh Framework Program grant (agreement No. HEALTH-F2-2009-241909, Project EU-GEI). The Oslo (Norway) cohort was funded by the Stiftelsen KG Jebsen, Research Council of Norway (#223273, under the Centers of Excellence funding scheme, and #300309, #283798) and the South-Eastern Norway Regional Health Authority (#2006233, #2006258, #2011085, #2014102, #2015088, #2017-112). The Paris (France) cohort was funded by European Community’s Seventh Framework Program grant (agreement No. HEALTHF2-2010–241909, Project EU-GEI). The Santander (Spain) cohort was funded by the following grants (to B.C.F): Instituto de Salud Carlos III, FIS 00/3095, PI020499, PI050427, PI060507, Plan Nacional de Drogas Research Grant 2005-Orden sco/3246/2004, and SENY Fundatio Research Grant CI 2005-0308007, Fundacion Marques de Valdecilla A/02/07 and API07/011. SAF2016-76046-R and SAF2013-46292-R (MINECO and FEDER). The West London (UK) cohort was funded The Wellcome Trust (Grant Numbers: 042025; 052247; 064607)

PsyCog:A computerised mini battery for assessing cognition in psychosis

Despite the functional impact of cognitive deficit in people with psychosis, objective cognitive assessment is not typically part of routine clinical care. This is partly due to the length of traditional assessments and the need for a highly trained administrator. Brief, automated computerised assessments could help to address this issue. We present data from an evaluation of PsyCog, a computerised, non-verbal, mini battery of cognitive tests. Healthy Control (HC) ( N = 135), Clinical High Risk (CHR) ( N = 233), and First Episode Psychosis (FEP) ( N = 301) participants from a multi-centre prospective study were assessed at baseline, 6 months, and 12 months. PsyCog was used to assess cognitive performance at baseline and at up to two follow-up timepoints. Mean total testing time was 35.95 min (SD = 2.87). Relative to HCs, effect sizes of performance impairments were medium to large in FEP patients (composite score G = 1.21, subtest range = 0.52-0.88) and small to medium in CHR patients (composite score G = 0.59, subtest range = 0.18-0.49). Site effects were minimal, and test-retest reliability of the PsyCog composite was good (ICC = 0.82-0.89), though some practice effects and differences in data completion between groups were found. The present implementation of PsyCog shows it to be a useful tool for assessing cognitive function in people with psychosis. Computerised cognitive assessments have the potential to facilitate the evaluation of cognition in psychosis in both research and in clinical care, though caution should still be taken in terms of implementation and study design. </p