Cosmic Pathways for Compact Groups in the Milli-Millennium Simulation

We detected 10 compact galaxy groups (CGs) at $z=0$ in the semi-analytic galaxy catalog of Guo et al. (2011) for the milli-Millennium Cosmological Simulation (sCGs in mGuo2010a). We aimed to identify potential canonical pathways for compact group evolution and thus illuminate the history of observed nearby compact groups. By constructing merger trees for $z=0$ sCG galaxies, we studied the cosmological evolution of key properties, and compared them with $z=0$ Hickson CGs (HCGs). We found that, once sCG galaxies come within 1 (0.5) Mpc of their most massive galaxy, they remain within that distance until $z=0$, suggesting sCG "birth redshifts". At $z=0$ stellar masses of sCG most-massive galaxies are within $10^{10} \lesssim M_{\ast}/M_{\odot} \lesssim 10^{11}$. In several cases, especially in the two 4- and 5-member systems, the amount of cold gas mass anti-correlates with stellar mass, which in turn correlates with hot gas mass. We define the angular difference between group members' 3D velocity vectors, $\Delta\theta_{\rm vel}$, and note that many of the groups are long-lived because their small values of $\Delta\theta_{\rm vel}$ indicate a significant parallel component. For triplets in particular, $\Delta\theta_{\rm vel}$ values range between $20^{\circ}$ and $40^{\circ}$ so that galaxies are coming together along roughly parallel paths, and pairwise separations do not show large pronounced changes after close encounters. The best agreement between sCG and HCG physical properties is for $M_{\ast}$ galaxy values, but HCG values are higher overall, including for SFRs. Unlike HCGs, due to a tail at low SFR and $M_{\ast}$, and a lack of $M_{\ast}\gtrsim 10^{11}M_{\odot}$ galaxies, only a few sCG galaxies are on the star-forming main sequence.Comment: Style fixes to better match ApJ published version. Uses likeapj1.1 style files: 17 pages, 13 figures, 2 tables. LaTex style files available at https://github.com/qtast/likeapj/releases/lates

Supersonic boundary-layer transition on the LaRC F-106 and the DFRF F-15 aircraft. Part 1: Transition measurements and stability analysis

For the case of the F-15 flight tests, boundary layer transition was observed up to Mach numbers of 1.2. For very limited and specific flight conditions, laminar flow existed back to about 20 percent chord on the surface clean up glove. Hot film instrumentation was effective for locating the region of transition. For the F-106 flight tests, transition on the wing or vertical tail generally occurred very near the attachment line. Transition was believed to be caused by either attachment line contamination or strong cross flow development due to the high sweep angles of the test articles. The compressibility analysis showed that cross flow N-factors were in the range of 5 to 12 at transition

Efficient, designable, and broad-bandwidth optical extinction via aspect-ratio-tailored silver nanodisks

Subwavelength resonators, ranging from single atoms to metallic nanoparticles, typically exhibit a narrow-bandwidth response to optical excitations. We computationally design and experimentally synthesize tailored distributions of silver nanodisks to extinguish light over broad and varied frequency windows. We show that metallic nanodisks are two-to-ten-times more efficient in absorbing and scattering light than common structures, and can approach fundamental limits to broadband scattering for subwavelength particles. We measure broadband extinction per volume that closely approaches theoretical predictions over three representative visible-range wavelength windows, confirming the high efficiency of nanodisks and demonstrating the collective power of computational design and experimental precision for developing new photonics technologies

A Large-Diameter Hollow-Shaft Cryogenic Motor Based on a Superconducting Magnetic Bearing for Millimeter-Wave Polarimetry

In this paper we present the design and measured performance of a novel cryogenic motor based on a superconducting magnetic bearing (SMB). The motor is tailored for use in millimeter-wave half-wave plate (HWP) polarimeters, where a HWP is rapidly rotated in front of a polarization analyzer or polarization-sensitive detector. This polarimetry technique is commonly used in cosmic microwave background (CMB) polarization studies. The SMB we use is composed of fourteen yttrium barium copper oxide (YBCO) disks and a contiguous neodymium iron boron (NdFeB) ring magnet. The motor is a hollow-shaft motor because the HWP is ultimately installed in the rotor. The motor presented here has a 100 mm diameter rotor aperture. However, the design can be scaled up to rotor aperture diameters of approximately 500 mm. Our motor system is composed of four primary subsystems: (i) the rotor assembly, which includes the NdFeB ring magnet, (ii) the stator assembly, which includes the YBCO disks, (iii) an incremental encoder, and (iv) the drive electronics. While the YBCO is cooling through its superconducting transition, the rotor is held above the stator by a novel hold and release mechanism (HRM). The encoder subsystem consists of a custom-built encoder disk read out by two fiber optic readout sensors. For the demonstration described in this paper, we ran the motor at 50 K and tested rotation frequencies up to approximately 10 Hz. The feedback system was able to stabilize the the rotation speed to approximately 0.4%, and the measured rotor orientation angle uncertainty is less than 0.15 deg. Lower temperature operation will require additional development activities, which we will discuss

Pan-squamous genomic profiling stratified by anatomic tumor site and viral association

Background: Squamous cell carcinomas (SCC) have diverse anatomic etiologies but may share common genomic biomarkers. We profiled 7,871 unique SCCs across nine anatomic sites to investigate commonality in genomic alterations (GA), tumor mutational burden (TMB), human papillomavirus (HPV) association, and mutational signatures. Methods: Tissue from over 8,100 unique SCC samples originating from nine anatomic sites (anogenital (anus, cervix, penis, vagina, vulva), esophagus, head and neck, lung, and skin) were sequenced by hybrid capture-based comprehensive genomic profiling to evaluate GA and TMB. About 3% of non-cutaneous SCC samples had UV signatures, indicative of potential primary site misdiagnoses, and were filtered from the analysis. Detection of HPV, including high-risk strains 16, 18, 31, 33, and 45, was implemented through de novo assembly of non-human sequencing reads and BLASTn comparison against all viral nucleotide sequences in the NCBI database. Results: The proportion of HPV+ patients by anatomic site varied, with the highest being anal (91%) and cervical (83%). The mutational landscape of each cohort was similar, regardless of anatomic origin, but clustered based on HPV status. The largest differences in GA frequency as stratified by HPV- vs. HPV+ were TP53 (87% vs. 12%), CDKN2A (45% vs. 6%), and PIK3CA (22% vs. 33%). The median TMB in cases originating from HPV-associated sites was similar, regardless of HPV status. Higher median TMB was observed in lung and skin cases, which exhibited significant enrichment of mutational signatures indicative of tobacco- and UV-induced DNA damage, respectively. Conclusions: HPV+ and HPV- SCC populations have distinct genomic profiles and, for the latter, anatomic site is correlated with TMB distribution, secondary to associated carcinogen exposure. As such, biomarkers such as TMB and UV signature can provide unexpected insight into site of origin misdiagnoses and may correlate with benefit from immune checkpoint inhibitors

PAYLEAN® Improves Growth and Carcass Merit of Pigs with 25% and 50% Nebraska Index Line Genes

The Nebraska Index Line excels in reproduction and is being used in industry breeding programs. However, because it has been selected only for litter size since 1981, growth and carcass merit of pure-line pigs are below industry standards. The objectives of this experiment were 1) to compare growth and carcass traits of Index cross pigs with either 50% or 25% Line I genes in a crossbreeding system typical of how the line is used in the industry and 2) to determine the effects of feeding 18 g PAYLEAN® per ton during the last 28 days of the feeding period on Index cross pigs. Line I was crossed with Danbred® USA Landrace (L) boars and Duroc-Hampshire terminal boars to produce F1 pigs with 50% Line I genes and terminal cross pigs with 25% Line I genes. Pigs with 25% Line I genes grew faster (2.03 vs. 1.97 lb/d) from 65 days of age to approximately 240 lb than pigs with 50% Line I genes (P \u3c 0.05). They also ate more feed per day although the difference was not significant (5.82 vs 5.76 lb per d). Thus, the difference between groups in feed conversion was small and not significant. Terminal cross pigs with 25% Line I genes had only 0.02 in less backfat at the end of the experiment than F1 pigs with 50% Line I genes, but they had significantly larger longissimus muscle area (6.42 vs 6.10 in2) and greater percentage carcass lean (52.4 vs 51 %). Pigs of both genetic groups and both barrows and gilts responded similarly to a diet with 18 g PAYLEAN® per ton. Feeding PAYLEAN® at 18 g/ton for 28 days significantly increased growth rate (2.19 vs. 1.80 lb/d), reduced feed intake (6.49 vs. 6.81 lb/d) improved efficiency of growth (0.33 vs 0.26 gain/ feed ratio, corresponding with 3.03 and 3.85 feed/gain ratios), increased carcass weight (185.4 vs 177.2 lb), increased dressing percentage (75.2 vs 74.3%), and increased carcass lean (53.6 vs 49.9%). Performance and carcass merit of pigs with 25% Line I genes were greater than for F1 pigs with 50% Line I genes, and feeding PAYLEAN® at the rate of 18 g per ton produced similar increases in performance and carcass merit of both groups

Human immunodeficiency virus rebound after suppression to < 400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression

This study evaluated 1433 human immunodeficiency virus (HIV)-infected patients starting highly active antiretroviral therapy (HAART), 409 (28%) of whom had prior nucleoside experience and achieved an HIV load of <400 copies/mL by 24 weeks of therapy. Three hundred seven patients experienced virus rebound during a total of 2773.3 person-years of follow-up. There was a higher rate of virus rebound among the patients with pre-HAART nucleoside experience (relative hazard [RH], 2.86; 95% confidence interval, 2.22-3.84; P < .0001) and a decreasing rate of virus rebound with increasing duration of virus suppression (i.e., time since achieving a virus load of <400 HIV RNA copies/mL) among both the nucleoside-experienced and naive patients (P < .0001), but the difference between the groups persisted into the third year of follow-up (P = .0007). Even patients who had experienced <2 months of nucleoside therapy before beginning HAART had an increased risk of virus rebound (RH, 1.95; P = .009). It appears that only a small period of pre-HAART nucleoside therapy is sufficient to confer a disadvantage, in terms of risk of virus rebound, that persists for several years

Effects of regional differences and demography in modelling foot-and-mouth disease in cattle at the national scale

Foot-and-mouth disease (FMD) is a fast-spreading viral infection that can produce large and costly outbreaks in livestock populations. Transmission occurs at multiple spatial scales, as can the actions used to control outbreaks. The US cattle industry is spatially expansive, with heterogeneous distributions of animals and infrastructure. We have developed a model that incorporates the effects of scale for both disease transmission and control actions, applied here in simulating FMD outbreaks in US cattle. We simulated infection initiating in each of the 3049 counties in the contiguous US, 100 times per county. When initial infection was located in specific regions, large outbreaks were more likely to occur, driven by infrastructure and other demographic attributes such as premises clustering and number of cattle on premises. Sensitivity analyses suggest these attributes had more impact on outbreak metrics than the ranges of estimated disease parameter values. Additionally, although shipping accounted for a small percentage of overall transmission, areas receiving the most animal shipments tended to have other attributes that increase the probability of large outbreaks. The importance of including spatial and demographic heterogeneity in modelling outbreak trajectories and control actions is illustrated by specific regions consistently producing larger outbreaks than others

The structure of the infinite models in integer programming

The infinite models in integer programming can be described as the convex hull of some points or as the intersection of halfspaces derived from valid functions. In this paper we study the relationships between these two descriptions. Our results have implications for corner polyhedra. One consequence is that nonnegative, continuous valid functions suffice to describe corner polyhedra (with or without rational data)