5,521 research outputs found
Quasi-periodic X-ray brightness fluctuations in an accreting millisecond pulsar
The relativistic plasma flows onto neutron stars that are accreting material
from stellar companions can be used to probe strong-field gravity as well as
the physical conditions in the supranuclear-density interiors of neutron stars.
Plasma inhomogeneities orbiting a few kilometres above the stars are observable
as X-ray brightness fluctuations on the millisecond dynamical timescale of the
flows. Two frequencies in the kilohertz range dominate these fluctuations: the
twin kilohertz quasi-periodic oscillations (kHz QPOs). Competing models for the
origins of these oscillations (based on orbital motions) all predict that they
should be related to the stellar spin frequency, but tests have been difficult
because the spins were not unambiguously known. Here we report the detection of
kHz QPOs from a pulsar whose spin frequency is known. Our measurements
establish a clear link between kHz QPOs and stellar spin, but one not predicted
by any current model. A new approach to understanding kHz QPOs is now required.
We suggest that a resonance between the spin and general relativistic orbital
and epicyclic frequencies could provide the observed relation between QPOs and
spin.Comment: Published in the 2003 July 3 issue of Natur
The Diabetes Manual trial protocol – a cluster randomized controlled trial of a self-management intervention for type 2 diabetes [ISRCTN06315411]
Background
The Diabetes Manual is a type 2 diabetes self-management programme based upon the clinically effective 'Heart Manual'. The 12 week programme is a complex intervention theoretically underpinned by self-efficacy theory. It is a one to one intervention meeting United Kingdom requirements for structured diabetes-education and is delivered within routine primary care.
Methods/design
In a two-group cluster randomized controlled trial, GP practices are allocated by computer minimisation to an intervention group or a six-month deferred intervention group. We aim to recruit 250 participants from 50 practices across central England. Eligibility criteria are adults able to undertake the programme with type 2 diabetes, not taking insulin, with HbA1c over 8% (first 12 months) and following an agreed protocol change over 7% (months 13 to 18). Following randomisation, intervention nurses receive two-day training and delivered the Diabetes Manual programme to participants. Deferred intervention nurses receive the training following six-month follow-up. Primary outcome is HbA1c with total and HDL cholesterol; blood pressure, body mass index; self-efficacy and quality of life as additional outcomes. Primary analysis is between-group HbA1c differences at 6 months powered to give 80% power to detect a difference in HbA1c of 0.6%. A 12 month cohort analysis will assess maintenance of effect and assess relationship between self-efficacy and outcomes, and a qualitative study is running alongside.
Discussion
This trial incorporates educational and psychological diabetes interventions into a single programme and assesses both clinical and psychosocial outcomes. The trial will increase our understanding of intervention transferability between conditions, those diabetes related health behaviours that are more or less susceptible to change through efficacy enhancing mechanisms and how this impacts on clinical outcomes
Issues in the Pharmacokinetics of Trichloroethylene and Its Metabolites
Much progress has been made in understanding the complex pharmacokinetics of trichloroethylene (TCE). Qualitatively, it is clear that TCE is metabolized to multiple metabolites either locally or into systemic circulation. Many of these metabolites are thought to have toxicologic importance. In addition, efforts to develop physiologically based pharmacokinetic (PBPK) models have led to a better quantitative assessment of the dosimetry of TCE and several of its metabolites. As part of a mini-monograph on key issues in the health risk assessment of TCE, this article is a review of a number of the current scientific issues in TCE pharmacokinetics and recent PBPK modeling efforts with a focus on literature published since 2000. Particular attention is paid to factors affecting PBPK modeling for application to risk assessment. Recent TCE PBPK modeling efforts, coupled with methodologic advances in characterizing uncertainty and variability, suggest that rigorous application of PBPK modeling to TCE risk assessment appears feasible at least for TCE and its major oxidative metabolites trichloroacetic acid and trichloroethanol. However, a number of basic structural hypotheses such as enterohepatic recirculation, plasma binding, and flow- or diffusion-limited treatment of tissue distribution require additional evaluation and analysis. Moreover, there are a number of metabolites of potential toxicologic interest, such as chloral, dichloroacetic acid, and those derived from glutathione conjugation, for which reliable pharmacokinetic data is sparse because of analytical difficulties or low concentrations in systemic circulation. It will be a challenge to develop reliable dosimetry for such cases
Can a falling tree make a noise in two forests at the same time?
It is a commonplace to claim that quantum mechanics supports the old idea
that a tree falling in a forest makes no sound unless there is a listener
present. In fact, this conclusion is far from obvious. Furthermore, if a
tunnelling particle is observed in the barrier region, it collapses to a state
in which it is no longer tunnelling. Does this imply that while tunnelling, the
particle can not have any physical effects? I argue that this is not the case,
and moreover, speculate that it may be possible for a particle to have effects
on two spacelike separate apparatuses simultaneously. I discuss the measurable
consequences of such a feat, and speculate about possible statistical tests
which could distinguish this view of quantum mechanics from a ``corpuscular''
one. Brief remarks are made about an experiment underway at Toronto to
investigate these issues.Comment: 9 pp, Latex, 3 figs, to appear in Proc. Obsc. Unr. Conf.; Fig 2
postscript repaired on 26.10.9
Accreting Neutron Stars in Low-Mass X-Ray Binary Systems
Using the Rossi X-ray Timing Explorer (RossiXTE), astronomers have discovered
that disk-accreting neutron stars with weak magnetic fields produce three
distinct types of high-frequency X-ray oscillations. These oscillations are
powered by release of the binding energy of matter falling into the strong
gravitational field of the star or by the sudden nuclear burning of matter that
has accumulated in the outermost layers of the star. The frequencies of the
oscillations reflect the orbital frequencies of gas deep in the gravitational
field of the star and/or the spin frequency of the star. These oscillations can
therefore be used to explore fundamental physics, such as strong-field gravity
and the properties of matter under extreme conditions, and important
astrophysical questions, such as the formation and evolution of millisecond
pulsars. Observations using RossiXTE have shown that some two dozen neutron
stars in low-mass X-ray binary systems have the spin rates and magnetic fields
required to become millisecond radio-emitting pulsars when accretion ceases,
but that few have spin rates above about 600 Hz. The properties of these stars
show that the paucity of spin rates greater than 600 Hz is due in part to the
magnetic braking component of the accretion torque and to the limited amount of
angular momentum that can be accreted in such systems. Further study will show
whether braking by gravitational radiation is also a factor. Analysis of the
kilohertz oscillations has provided the first evidence for the existence of the
innermost stable circular orbit around dense relativistic stars that is
predicted by strong-field general relativity. It has also greatly narrowed the
possible descriptions of ultradense matter.Comment: 22 pages, 7 figures, updated list of sources and references, to
appear in "Short-period Binary Stars: Observation, Analyses, and Results",
eds. E.F. Milone, D.A. Leahy, and D. Hobill (Dordrecht: Springer,
http://www.springerlink.com
Bituminous mixtures with low percentage of natural aggregates and rubber modified bitumen with wax
The three mixtures included in the Spanish specifications (asphalt concrete, porous asphalt and very thin asphalt concrete) were designed replacing more than 80% of the natural aggregates by black slag of electric arc furnace and recycled asphalt pavement. Besides, a rubber modified bitumen was used as binder, analyzing the performance of a fatty acid amide wax as additive to decrease its viscosity at mixing temperature, and avoid the higher manufacturing temperature of this type of bitumen. Three stages were carried out to design the mixtures: first, the viscosity analysis of the rubber modified bitumen when the wax is added. Second, the experimental design of the mixtures with the alternative aggregates at conventional temperature, using the rubber modified bitumen without wax. Finally, the study of the behaviour of the three mixes with the same dosage of the previous phase, but manufactured at reduced temperature, that is including the fatty acid amide wax to the binder.
The tests of the Spanish specifications have been performed to design the mixtures and compare their performance in both conditions (with and without wax): void characteristics, water sensitivity test, wheel tracking test, and Cantabro loss particle test in dry and wet conditions. The results have shown that it is feasible to design mixtures in which practically the whole mineral skeleton comes from black slag and recycled asphalt, manufacturing them with a rubber modified bitumen but at the same range of temperatures than conventional 50/70 penetration grade binder, and fulfilling the standards for any climatic zone and heavy traffic level
Prime tight frames
We introduce a class of finite tight frames called prime tight frames and prove some of their elementary properties. In particular, we show that any finite tight frame can be written as a union of prime tight frames. We then characterize all prime harmonic tight frames and use this characterization to suggest effective analysis and synthesis computation strategies for such frames. Finally, we describe all prime frames constructed from the spectral tetris method, and, as a byproduct, we obtain a characterization of when the spectral tetris construction works for redundancies below two
Evolution of Landau Levels into Edge States at an Atomically Sharp Edge in Graphene
The quantum-Hall-effect (QHE) occurs in topologically-ordered states of
two-dimensional (2d) electron-systems in which an insulating bulk-state
coexists with protected 1d conducting edge-states. Owing to a unique
topologically imposed edge-bulk correspondence these edge-states are endowed
with universal properties such as fractionally-charged quasiparticles and
interference-patterns, which make them indispensable components for QH-based
quantum-computation and other applications. The precise edge-bulk
correspondence, conjectured theoretically in the limit of sharp edges, is
difficult to realize in conventional semiconductor-based electron systems where
soft boundaries lead to edge-state reconstruction. Using scanning-tunneling
microscopy and spectroscopy to follow the spatial evolution of bulk
Landau-levels towards a zigzag edge of graphene supported above a graphite
substrate we demonstrate that in this system it is possible to realize
atomically sharp edges with no edge-state reconstruction. Our results single
out graphene as a system where the edge-state structure can be controlled and
the universal properties directly probed.Comment: 16 pages, 4 figure
Quantum fluctuations can promote or inhibit glass formation
The very nature of glass is somewhat mysterious: while relaxation times in
glasses are of sufficient magnitude that large-scale motion on the atomic level
is essentially as slow as it is in the crystalline state, the structure of
glass appears barely different than that of the liquid that produced it.
Quantum mechanical systems ranging from electron liquids to superfluid helium
appear to form glasses, but as yet no unifying framework exists connecting
classical and quantum regimes of vitrification. Here we develop new insights
from theory and simulation into the quantum glass transition that surprisingly
reveal distinct regions where quantum fluctuations can either promote or
inhibit glass formation.Comment: Accepted for publication in Nature Physics. 22 pages, 3 figures, 1
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IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68
BACKGROUND: Herpesviruses can be neutralized in vitro but remain infectious in immune hosts. One difference between these settings is the availability of immunoglobulin Fc receptors. The question therefore arises whether a herpesvirus exposed to apparently neutralizing antibody can still infect Fc receptor(+) cells. PRINCIPAL FINDINGS: Immune sera blocked murine gamma-herpesvirus-68 (MHV-68) infection of fibroblasts, but failed to block and even enhanced its infection of macrophages and dendritic cells. Viral glycoprotein-specific monoclonal antibodies also enhanced infection. MHV-68 appeared to be predominantly latent in macrophages regardless of whether Fc receptors were engaged, but the infection was not abortive and new virus production soon overwhelmed infected cultures. Lytically infected macrophages down-regulated MHC class I-restricted antigen presentation, endocytosis and their response to LPS. CONCLUSIONS: IgG Fc receptors limit the neutralization of gamma-herpesviruses such as MHV-68
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