121,534 research outputs found
Second order parameter-uniform convergence for a finite difference method for a singularly perturbed linear reaction-diffusion system
A singularly perturbed linear system of second order ordinary differential
equations of reaction-diffusion type with given boundary conditions is
considered. The leading term of each equation is multiplied by a small positive
parameter. These singular perturbation parameters are assumed to be distinct.
The components of the solution exhibit overlapping layers. Shishkin
piecewise-uniform meshes are introduced, which are used in conjunction with a
classical finite difference discretisation, to construct a numerical method for
solving this problem. It is proved that the numerical approximations obtained
with this method is essentially second order convergent uniformly with respect
to all of the parameters
Composition profiling InAs quantum dots and wetting layers by atom probe tomography and cross-sectional scanning tunnelling microscopy
This study compares cross-sectional scanning tunnelling microscopy (XSTM) and
atom probe tomography (APT). We use epitaxially grown self-assembled InAs
quantum dots (QDs) in GaAs as an exemplary material with which to compare these
two nanostructural analysis techniques. We studied the composition of the
wetting layer and the QDs, and performed quantitative comparisons of the indium
concentration profiles measured by each method. We show that computational
models of the wetting layer and the QDs, based on experimental data, are
consistent with both analytical approaches. This establishes a link between the
two techniques and shows their complimentary behaviour, an advantage which we
exploit in order to highlight unique features of the examined QD material.Comment: Main article: 8 pages, 6 figures. Appendix: 3 pages, 5 figure
Inelastic semiclassical Coulomb scattering
We present a semiclassical S-matrix study of inelastic collinear
electron-hydrogen scattering. A simple way to extract all necessary information
from the deflection function alone without having to compute the stability
matrix is described. This includes the determination of the relevant Maslov
indices. Results of singlet and triplet cross sections for excitation and
ionization are reported. The different levels of approximation -- classical,
semiclassical, and uniform semiclassical -- are compared among each other and
to the full quantum result.Comment: 9 figure
Alloreactive cytotoxic T lymphocytes generated in the presence of viral- derived peptides show exquisite peptide and MHC specificity
The nature of alloreactivity to MHC molecules has been enigmatic, primarily because of the observation that allogeneic responses are considerably stronger than syngeneic responses. To better determine the specificity potential of allogeneic responses, we have generated alloreactive CTL specific for exogenous, viral-derived peptide ligands. This approach allowed us to critically evaluate both the peptide- and MHC-specificity of these alloreactive T cells. Exploiting the accessibility of the H-2Ld class I molecule for exogenous peptide ligands, alloreactive CTL were generated that are specific for either murine cytomegalovirus (MCMV) or lymphocytic choriomeningitis virus (LCMV) peptides bound by Ld alloantigens. Peptide specificity was initially observed in bulk cultures of alloreactive CTL only when tested on peptide-sensitized T2.Ld target cells that have defective presentation of endogenous peptides. Subsequent cloning of bulk alloreactive CTL lines generated to MCMV yielded CTL clones that had exquisitely specific MCMV peptide recognition requirement. All of the MCMV/Ld alloreactive CTL clones were also exquisitely MHC-specific in that none of the CTL clones lysed targets expressing MCMV/Lq complexes, even though Lq differs from Ld by only six amino acid residues and Lq also binds the MCMV peptide. This observation clearly demonstrates that alloreactive CTL are capable of the same degree of specificity for target cell recognition as are syngeneic CTL in MHC-restricted responses
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