Retrieve and Refine: Improved Sequence Generation Models For Dialogue

Sequence generation models for dialogue are known to have several problems: they tend to produce short, generic sentences that are uninformative and unengaging. Retrieval models on the other hand can surface interesting responses, but are restricted to the given retrieval set leading to erroneous replies that cannot be tuned to the specific context. In this work we develop a model that combines the two approaches to avoid both their deficiencies: first retrieve a response and then refine it -- the final sequence generator treating the retrieval as additional context. We show on the recent CONVAI2 challenge task our approach produces responses superior to both standard retrieval and generation models in human evaluations

Rational Catalan Numbers for Complex Reflection Groups

Assuming standard conjectures, we show that the canonical symmetrizing trace evaluated at powers of a Coxeter element produces rational Catalan numbers for irreducible spetsial complex reflection groups. This extends a technique used by Galashin, Lam, Trinh, and Williams to uniformly prove the enumeration of their noncrossing Catalan objects for finite Coxeter groups.Comment: 28 pages, 2 figure

Strongly non embeddable metric spaces

Enflo constructed a countable metric space that may not be uniformly embedded into any metric space of positive generalized roundness. Dranishnikov, Gong, Lafforgue and Yu modified Enflo's example to construct a locally finite metric space that may not be coarsely embedded into any Hilbert space. In this paper we meld these two examples into one simpler construction. The outcome is a locally finite metric space $(\mathfrak{Z}, \zeta)$ which is strongly non embeddable in the sense that it may not be embedded uniformly or coarsely into any metric space of non zero generalized roundness. Moreover, we show that both types of embedding may be obstructed by a common recursive principle. It follows from our construction that any metric space which is Lipschitz universal for all locally finite metric spaces may not be embedded uniformly or coarsely into any metric space of non zero generalized roundness. Our construction is then adapted to show that the group $\mathbb{Z}_\omega=\bigoplus_{\aleph_0}\mathbb{Z}$ admits a Cayley graph which may not be coarsely embedded into any metric space of non zero generalized roundness. Finally, for each $p \geq 0$ and each locally finite metric space $(Z,d)$, we prove the existence of a Lipschitz injection $f : Z \to \ell_{p}$.Comment: 10 page

Elevated cerebral spinal fluid biomarkers in children with mucopolysaccharidosis I-H.

Mucopolysaccharidosis (MPS) type-IH is a lysosomal storage disease that results from mutations in the IDUA gene causing the accumulation of glycosaminoglycans (GAGs). Historically, children with the severe phenotype, MPS-IH (Hurler syndrome) develop progressive neurodegeneration with death in the first decade due to cardio-pulmonary complications. New data suggest that inflammation may play a role in MPS pathophysiology. To date there is almost no information on the pathophysiologic changes within the cerebral spinal fluid (CSF) of these patients. We evaluated the CSF of 25 consecutive patients with MPS-IH. While CSF glucose and total protein were within the normal range, we found a significantly mean elevated CSF opening pressure at 24 cm H2O (range 14-37 cm H2O). We observed a 3-fold elevation in CSF heparan sulfate and a 3-8 fold increase in MPS-IH specific non-reducing ends, I0S0 and I0S6. Cytokine analyses in CSF of children with MPS-IH showed significantly elevated inflammatory markers including: MCP-1 SDF-1a, IL-Ra, MIP-1b, IL-8, and VEGF in comparison to unaffected children. This is the largest report of CSF characteristics in children with MPS-IH. Identification of key biomarkers may provide further insight into the inflammatory-mediated mechanisms related to MPS diseases and perhaps lead to improved targeted therapies

State-of-the-art glycosaminoglycan characterization

Glycosaminoglycans (GAGs) are heterogeneous acidic polysaccharides involved in a range of biological functions. They have a significant influence on the regulation of cellular processes and the development of various diseases and infections. To fully understand the functional roles that GAGs play in mammalian systems, including disease processes, it is essential to understand their structural features. Despite having a linear structure and a repetitive disaccharide backbone, their structural analysis is challenging and requires elaborate preparative and analytical techniques. In particular, the extent to which GAGs are sulfated, as well as variation in sulfate position across the entire oligosaccharide or on individual monosaccharides, represents a major obstacle. Here, we summarize the current state-of-the-art methodologies used for GAG sample preparation and analysis, discussing in detail liquid chromatograpy and mass spectrometry-based approaches, including advanced ion activation methods, ion mobility separations and infrared action spectroscopy of mass-selected species

Hope for resurrecting a functionally extinct parrot or squandered social capital? Landholder attitudes towards the Orange-bellied Parrot (Neophema chrysogaster) in Victoria, Australia

In early 2010, after 27 years of recovery effort, the orange-bellied parrot (OBP; Neophema chrysogaster) was expected to be extinct in the wild within a few years. Shortly before the imminent wild extinction became evident, we surveyed landholders (114 responses of 783 surveys delivered) in part of the main non-breeding area, according to three classes of modelled habitat suitability (\u27high\u27, \u27medium\u27, and \u27low\u27). Predictions of the habitat models appear to correlate with landholder perceptions of the presence of OBP habitat on private land, thus the models appear a tractable way to identify key stakeholders worthy of priority consultation in relation to habitat works. Landholders were sympathetic to wetlands and birds, including OBPs (89.4% were aware of OBPs). Most indicated that they would be upset if the OBP went extinct and agreed that critical habitat should be protected; 80.7% were prepared to consider changes to the way they managed their land to benefit the species, and sought more information on how they could do so (64.0%). This study suggests that the habitat model usefully identified key stakeholders and the OBP enjoyed high awareness, concern, and engagement among many stakeholders, shortly before the species was considered functionally extinct. The maintenance of landholder support is likely to be critical if future attempts are made to reintroduce the species to the wild