1,341 research outputs found
T Regulatory Cells: An Overview and Intervention Techniques to Modulate Allergy Outcome
Dysregulated immune response results in inflammatory symptoms in the respiratory mucosa leading to asthma and allergy in susceptible individuals. The T helper type 2 (Th2) subsets are primarily involved in this disease process. Nevertheless, there is growing evidence in support of T cells with regulatory potential that operates in non-allergic individuals. These regulatory T cells occur naturally are called natural T regulatory cells (nTregs) and express the transcription factor Foxp3. They are selected in the thymus and move to the periphery. The CD4 Th cells in the periphery can be induced to become regulatory T cells and hence called induced or adaptive T regulatory cells. These cells can make IL-10 or TGF-b or both, by which they attain most of their suppressive activity. This review gives an overview of the regulatory T cells, their role in allergic diseases and explores possible interventionist approaches to manipulate Tregs for achieving therapeutic goals
Cytochrome P450 CYP1B1 in breast cancer.
This poster gives an overview of recent research into cytochrome P450 CYP1B1, which has previously been shown to present increased expression in several types of human cancer. This study specifically used immunohistochemistry to investigate the expression of CYP1B1 in a series of primary breast cancers. The majority of breast cancers showed positive immunoreactivity for CYP1B1 and this enzyme was specifically localised to tumour cells. This is likely to contribute to breast cancer cells' metabolism of oestradiol and also means that CYP1B1 provides a molecular target for anti-cancer drugs that are specifically activated by this form of P450
A Study of a Wireless Smart Sensor Platform for Practical Training
[[abstract]]In order to overcome the obstacles in traditional experimenting and practical training courses, as well as in enhancing the functions of the present e-learning system, the study took sensor network technology as the foundation in developing a web services system. The system will be able to make presentations of the students ‘operations and results on an immediate basis, allowing the students to be guided adequately as they face problems during experiment and practical training.[[booktype]]紙
Gold slows down the growth of helium bubble in iron
We predict by first-principles calculations that Au have strong affinity to
He in bcc Fe. The Au-Au bonding in the segregated Au layer at the He bubble
surface is stronger than Fe-Fe and Au-Fe interactions; therefore this layer
becomes an effective barrier to further He and slows down the bubble growth.Comment: 9 pages, 4 figures, 1 tabl
Superconductors with Magnetic Impurities: Instantons and Sub-gap States
When subject to a weak magnetic impurity potential, the order parameter and
quasi-particle energy gap of a bulk singlet superconductor are suppressed.
According to the conventional mean-field theory of Abrikosov and Gor'kov, the
integrity of the energy gap is maintained up to a critical concentration of
magnetic impurities. In this paper, a field theoretic approach is developed to
critically analyze the validity of the mean field theory. Using the
supersymmetry technique we find a spatially homogeneous saddle-point that
reproduces the Abrikosov-Gor'kov theory, and identify instanton contributions
to the density of states that render the quasi-particle energy gap soft at any
non-zero magnetic impurity concentration. The sub-gap states are associated
with supersymmetry broken field configurations of the action. An analysis of
fluctuations around these configurations shows how the underlying supersymmetry
of the action is restored by zero modes. An estimate of the density of states
is given for all dimensionalities. To illustrate the universality of the
present scheme we apply the same method to study `gap fluctuations' in a normal
quantum dot coupled to a superconducting terminal. Using the same instanton
approach, we recover the universal result recently proposed by Vavilov et al.
Finally, we emphasize the universality of the present scheme for the
description of gap fluctuations in d-dimensional superconducting/normal
structures.Comment: 18 pages, 9 eps figure
Donor states in modulation-doped Si/SiGe heterostructures
We present a unified approach for calculating the properties of shallow
donors inside or outside heterostructure quantum wells. The method allows us to
obtain not only the binding energies of all localized states of any symmetry,
but also the energy width of the resonant states which may appear when a
localized state becomes degenerate with the continuous quantum well subbands.
The approach is non-variational, and we are therefore also able to evaluate the
wave functions. This is used to calculate the optical absorption spectrum,
which is strongly non-isotropic due to the selection rules. The results
obtained from calculations for Si/SiGe quantum wells allow us to
present the general behavior of the impurity states, as the donor position is
varied from the center of the well to deep inside the barrier. The influence on
the donor ground state from both the central-cell effect and the strain arising
from the lattice mismatch is carefully considered.Comment: 17 pages, 10 figure
Production and Decay of D_1(2420)^0 and D_2^*(2460)^0
We have investigated and final states and
observed the two established charmed mesons, the with mass
MeV/c and width MeV/c and
the with mass MeV/c and width
MeV/c. Properties of these final states, including
their decay angular distributions and spin-parity assignments, have been
studied. We identify these two mesons as the doublet predicted
by HQET. We also obtain constraints on {\footnotesize } as a function of the cosine of the relative phase of the two
amplitudes in the decay.Comment: 15 pages in REVTEX format. hardcopies with figures can be obtained by
sending mail to: [email protected]
Measurement of the branching fraction for
We have studied the leptonic decay of the resonance into tau
pairs using the CLEO II detector. A clean sample of tau pair events is
identified via events containing two charged particles where exactly one of the
particles is an identified electron. We find . The result is consistent with
expectations from lepton universality.Comment: 9 pages, RevTeX, two Postscript figures available upon request, CLNS
94/1297, CLEO 94-20 (submitted to Physics Letters B
Measurement of the Decay Asymmetry Parameters in and
We have measured the weak decay asymmetry parameters (\aLC ) for two \LC\
decay modes. Our measurements are \aLC = -0.94^{+0.21+0.12}_{-0.06-0.06} for
the decay mode and \aLC = -0.45\pm 0.31 \pm
0.06 for the decay mode . By combining these
measurements with the previously measured decay rates, we have extracted the
parity-violating and parity-conserving amplitudes. These amplitudes are used to
test models of nonleptonic charmed baryon decay.Comment: 11 pages including the figures. Uses REVTEX and psfig macros. Figures
as uuencoded postscript. Also available as
http://w4.lns.cornell.edu/public/CLNS/1995/CLNS95-1319.p
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