Partial Averaging Approach to Fourier Coefficient Path Integration

The recently introduced method of partial averaging is developed in a general formalism for computing simple Cartesian path integrals. Examples of its application to both harmonic and anharmonic systems are given. For harmonic systems, where analytical results can be derived, both imaginary and complex time evolution is discussed. For two representative anharmonic systems, Monte Carlo path integral simulations of the imaginary time propagator (statistical density matrix) are presented. Connections with other Cartesian path integral techniques are stressed

Creep in Photovoltaic Modules: Examining the Stability of Polymeric Materials and Components

Interest in renewable energy has motivated the implementation of new polymeric materials in photovoltaic modules. Some of these are non-cross-linked thermoplastics, in which there is a potential for new behaviors to occur, including phase transformation and visco-elastic flow. Differential scanning calorimetry and rheometry data were obtained and then combined with existing site-specific time-temperature information in a theoretical analysis to estimate the displacement expected to occur during module service life. The analysis identified that, depending on the installation location, module configuration and/or mounting configuration, some of the thermoplastics are expected to undergo unacceptable physical displacement. While the examples here focus on encapsulation materials, the concerns apply equally to the frame, junction-box, and mounting-adhesive technologies

The hard quiescent spectrum of the neutron-star X-ray transient EXO 1745-248 in the globular cluster Terzan 5

We present a Chandra observation of the globular cluster Terzan 5 during times when the neutron-star X-ray transient EXO 1745-248 located in this cluster was in its quiescent state. We detected the quiescent system with a (0.5-10 keV) luminosity of ~2 x 10^{33} ergs/s. This is similar to several other neutron-star transients observed in their quiescent states. However, the quiescent X-ray spectrum of EXO 1745--48 was dominated by a hard power-law component instead of the soft component that usually dominates the quiescent emission of other neutron-star X-ray transients. This soft component could not conclusively be detected in EXO 1745-248 and we conclude that it contributed at most 10% of the quiescent flux in the energy range 0.5-10 keV. EXO 1745-248 is only the second neutron-star transient whose quiescent spectrum is dominated by the hard component (SAX J1808.4-3658 is the other one). We discuss possible explanations for this unusual behavior of EXO 1745-248, its relationship to other quiescent neutron-star systems, and the impact of our results on understanding quiescent X-ray binaries. We also discuss the implications of our results on the way the low-luminosity X-ray sources in globular clusters are classified.Comment: Accepted by ApJ Main Journal, September 22, 2004. Figure 2 is a color figur

High-Resolution Chandra Spectroscopy Of Tau Scorpii: A Narrow-Line X-Ray Spectrum From A Hot Star

Long known to be an unusual early-type star by virtue of its hard and strong X-ray emission, tau Scorpii poses a severe challenge to the standard picture of O-star wind-shock X-ray emission. The Chandra HETGS spectrum now provides significant direct evidence that this B0.2 star does not fit this standard wind-shock framework. The many emission lines detected with the Chandra gratings are significantly narrower than what would be expected from a star with the known wind properties of tau Sco, although they are broader than the corresponding lines seen in late-type coronal sources. While line ratios are consistent with the hot plasma on this star being within a few stellar radii of the photosphere, from at least one He-like complex there is evidence that the X-ray emitting plasma is located more than a stellar radius above the photosphere. The Chandra spectrum of Sco is harder and more variable than those of other hot stars, with the exception of the young magnetized O star theta(1) Ori C. We discuss these new results in the context of wind, coronal, and hybrid wind-magnetic models of hot-star X-ray emission

MicroRNA profiling reveals marker of motor neuron disease in ALS models

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by the loss of motor neurons (MNs) in the brain and spinal cord, leading to fatally debilitating weakness. Because this disease predominantly affects MNs, we aimed to characterize the distinct expression profile of that cell type to elucidate underlying disease mechanisms and to identify novel targets that inform on MN health during ALS disease time course. microRNAs (miRNAs) are short, noncoding RNAs that can shape the expression profile of a cell and thus often exhibit cell-type-enriched expression. To determine MN-enriched miRNA expression, we used Cre recombinase-dependent miRNA tagging and affinity purification in mice. By defining thein vivomiRNA expression of MNs, all neurons, astrocytes, and microglia, we then focused on MN-enriched miRNAs via a comparative analysis and found that they may functionally distinguish MNs postnatally from other spinal neurons. Characterizing the levels of the MN-enriched miRNAs in CSF harvested from ALS models of MN disease demonstrated that one miRNA (miR-218) tracked with MN loss and was responsive to an ALS therapy in rodent models. Therefore, we have used cellular expression profiling tools to define the distinct miRNA expression of MNs, which is likely to enrich future studies of MN disease. This approach enabled the development of a novel, drug-responsive marker of MN disease in ALS rodents.SIGNIFICANCE STATEMENTAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons (MNs) in the brain and spinal cord are selectively lost. To develop tools to aid in our understanding of the distinct expression profiles of MNs and, ultimately, to monitor MN disease progression, we identified small regulatory microRNAs (miRNAs) that were highly enriched or exclusive in MNs. The signal for one of these MN-enriched miRNAs is detectable in spinal tap biofluid from an ALS rat model, where its levels change as disease progresses, suggesting that it may be a clinically useful marker of disease status. Furthermore, rats treated with ALS therapy have restored expression of this MN RNA marker, making it an MN-specific and drug-responsive marker for ALS rodents.</jats:p

Conditional Quantum Dynamics and Logic Gates

Quantum logic gates provide fundamental examples of conditional quantum dynamics. They could form the building blocks of general quantum information processing systems which have recently been shown to have many interesting non--classical properties. We describe a simple quantum logic gate, the quantum controlled--NOT, and analyse some of its applications. We discuss two possible physical realisations of the gate; one based on Ramsey atomic interferometry and the other on the selective driving of optical resonances of two subsystems undergoing a dipole--dipole interaction.Comment: 5 pages, RevTeX, two figures in a uuencoded, compressed fil

E-Type Delayed Fluorescence of a Phosphine-Supported Cu_2(μ-NAr_2)_2 Diamond Core: Harvesting Singlet and Triplet Excitons in OLEDs

A highly emissive bis(phosphine)diarylamido dinuclear copper(I) complex (quantum yield = 57%) was shown to exhibit E-type delayed fluorescence by variable temperature emission spectroscopy and photoluminescence decay measurement of doped vapor-deposited films. The lowest energy singlet and triplet excited states were assigned as charge transfer states on the basis of theoretical calculations and the small observed S_1−T_1 energy gap. Vapor-deposited OLEDs doped with the complex in the emissive layer gave a maximum external quantum efficiency of 16.1%, demonstrating that triplet excitons can be harvested very efficiently through the delayed fluorescence channel. The function of the emissive dopant in OLEDs was further probed by several physical methods, including electrically detected EPR, cyclic voltammetry, and photoluminescence in the presence of applied current

Sentinel Case of Candida auris in the Western United States Following Prolonged Occult Colonization in a Returned Traveler from India.

Candida auris is an emerging multidrug-resistant yeast with high mortality. We report the sentinel C. auris case on the United States West Coast in a patient who relocated from India. We identified close phylogenetic relatedness to the South Asia clade and ERG11 Y132F and FKS1 S639Y mutations potentially explaining antifungal resistance