Alien Registration- Miller, Clara M. (Monticello, Aroostook County)

https://digitalmaine.com/alien_docs/33987/thumbnail.jp

The birds and the bees can have canes and wheels : the sexual identity formation of women with visible physical disabilities

The study descriptively examines the views women with visible physical disabilities have on their sexual identity formation. For the purposes of this study, the term sexual identity is defined as an awareness of one\u27s self as a sexual being. 158 self-identified women with visible physical disabilities answered survey questions about their experiences during their adolescent years. Overall, this study found that women with disabilities face the same difficulties as their abled-bodied peers, but face additional struggles having to do with their disability when forming their sexual identity

A Promising Place-Based Collaborative Impact Investing Fund Strengthens Community and Informs Philanthropic Practice

A recent evaluation of the Western New York Impact Investment Fund adds to the proof-of-concept literature regarding “doing good and doing well” while pointing to experience-based best practices in philanthropic impact investing. Born of a collaboration between regional and national philanthropies, the fund brings together corporate, individual, and philanthropic investors to deliver an inclusive impact investment mechanism. Founded in 2017, the fund evolved from concept to operating entity, focusing on mitigating capital gaps, longterm economic decline, and wealth divides. Evaluation at Year 5 describes how the professionally managed, collaboratively governed fund has attracted and deployed capital, contributing to ecosystem improvements and concrete results. Portfolio companies have created jobs with livable wages, reduced carbon footprints, reclaimed abandoned space, and committed to maintain operations in the region long term. Alongside these impacts, investors’ stakes have increased in value and realized returns. Performance bred opportunity and its second round of fundraising, 42% larger than the first, brought the total under management to over $20 million. With this evaluation, the Western New York Impact Investment Fund articulates lessons for the fund, foundation investors, and intermediaries seeking to nurture place-based impact investing

Cape York Kidney Care: service description and baseline characteristics of a client-centred multidisciplinary specialist kidney health service in remote Australia

Background: Chronic Kidney disease (CKD) is over-represented amongst First Nation people with more than triple the rate of CKD in those aged 15 years and over. The impact of colonisation, including harmful experiences of health practices and research, has contributed to these health inequities. Cape York Kidney Care (CYKC) has been created as an unique service which provides specialist care that aims to centre the client within a multidisciplinary team that is integrated within the primary care setting of the remote health clinics in six communities in western Cape York, Australia. This research aims to describe the Cape York Kidney Care service delivery model, and baseline service data, including aggregated client health measures. Methods: The model of care is described in detail. Review of the first 12 months of service provision has been undertaken with client demographic and clinical profile baseline data collected including kidney health measures. Participants are adults (> 18 years if age) with CKD grades 1–5. This data has been de-identified and aggregated. Results: CYKC reviewed 204 individuals, with 182 not previously been reviewed by specialist kidney health services. Three quarters of clients identified as Aboriginal. The average age was 55 with a high level of comorbidity, with majority having a history of hypertension and Type 2 diabetes (average Hba1c 8.2%). Just under one third had cardiovascular disease. A large proportion of people had either Grade 2 CKD (32%) or Grade 3 CKD (~ 30%), and over half had severely increased albuminuria (A3), with Type 2 diabetes being the predominant presumed cause of CKD. Most clients did not meet evidence-based targets for diabetes, blood pressure or lipids and half were self-reported smokers. The proportion of clients reviewed represents 6.2% of the adult population in the participating First Nation communities. Conclusion: The CYKC model was able to target those clients at high risk of progression and increase the number of people with chronic kidney disease reviewed by specialist kidney services within community. Baseline data demonstrated a high burden of chronic disease that subsequently will increase risk of CKD progression and cardiovascular disease. People were seen to have more severe disease at younger ages, with a substantial number demonstrating risk factors for rapid progression of kidney disease including poorly controlled Type 2 diabetes and severely increased albuminuria. Further evaluation concerning implementation challenges, consumer and community satisfaction, and health outcomes is required

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.

PGAM5 is a mitochondrial protein phosphatase whose genetic ablation in mice results in mitochondria-related disorders, including neurodegeneration. Functions of PGAM5 include regulation of mitophagy, cell death, metabolism and aging. However, mechanisms regulating PGAM5 activation and signaling are poorly understood. Using electron cryo-microscopy, we show that PGAM5 forms dodecamers in solution. We also present a crystal structure of PGAM5 that reveals the determinants of dodecamer formation. Furthermore, we observe PGAM5 dodecamer assembly into filaments both in vitro and in cells. We find that PGAM5 oligomerization into a dodecamer is not only essential for catalytic activation, but this form also plays a structural role on mitochondrial membranes, which is independent of phosphatase activity. Together, these findings suggest that modulation of the oligomerization of PGAM5 may be a regulatory switch of potential therapeutic interest

Effect of Weekly and Triweekly Application of Growth Hormone Gibberellin on Dwarf Millet Plants

Plant biology students teamed up with statistics students to examine the effects of the plant growth hormone gibberellin on mutant millet plants. Dwarf mutant millets exhibit stunted growth either because they do not produce gibberellin on their own, or because they lack the mechanisms to effectively use gibberellin. By growing some of these mutants in the greenhouse, applying a gibberellin solution to them, and observing their growth response, we can identify which kind of mutant the plant is. We are also examining the importance of frequency of gibberellin application, with some plants receiving one application of gibberellin per week, and some receiving three

Experiences and perceptions regarding clinical breast exam screening by trained laywomen in Malawi

Despite the increasing burden, breast cancer control in sub-Saharan Africa is insufficient. Late diagnosis and lack of early detection and screening services contribute to high mortality. Clinical breast exam (CBE) screening can be valuable in low-income countries, including use of community health workers and non-health professionals to conduct exams. We assessed experiences of women who underwent CBE screening by trained laywomen in Lilongwe, Malawi, as part of a pilot program

Respiration cycle duration and seawater flux through open blowholes of humpback (Megaptera novaeangliae) and North Atlantic right (Eubalaena glacialis) whales

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Martins, M. C. I., Miller, C., Hamilton, P., Robbins, J., Zitterbart, D. P., & Moore, M. Respiration cycle duration and seawater flux through open blowholes of humpback (Megaptera novaeangliae) and North Atlantic right (Eubalaena glacialis) whales. Marine Mammal Science, (2020): 1-20, doi:10.1111/mms.12703.Little is known about the dynamics of baleen whale respiratory cycles, especially the mechanics and activity of the blowholes and their interaction with seawater. In this study, the duration of complete respiration cycles (expiration/inhalation events) were quantified for the first time in two species: North Atlantic right whale (NARW) and humpback whale (HW) using high resolution, detailed imagery from an unoccupied aerial system (UAS). The mean duration of complete respiration cycles (expiration/inhalation event) in the NARW and HW were 3.07 s (SD = 0.503, n = 15) and 2.85 s (SD = 0.581, n = 21), respectively. Furthermore, we saw no significant differences in respiration cycle duration between age and sex classes in the NARW, but significant differences were observed between age classes in the HW. The observation of seawater covering an open blowhole was also quantified, with NARW having 20% of all breaths with seawater presence versus 90% in HW. Seawater incursion has not been described previously and challenges the general consensus that water does not enter the respiratory tract in baleen whales. Prevalent seawater has implications for the analysis and interpretation of exhaled respiratory vapor/mucosa samples, as well as for the potential inhalation of oil in spills.Samples were collected under NMFS NOAA Permits 17355, 17355‐01, and 21371, and with approval from the Woods Hole Oceanographic Institution Institutional Animal Care and Use Committee. Funding by Ocean Life Institute of the Woods Hole Oceanographic Institution, NOAA NA14OAR4320158 and University College London Master of Research in Biodiversity, Evolution and Conservation program

The history of Ashland College, 1878-1953

Gerald W. Williams Collectio