Co-seismic deformation of deep slabs based on summed CMT data

We assess the co-seismic deformation inferred from earthquake moment tensor solutions for subducting slabs at depths greater than 50 km globally. We rotate each moment tensor into a local slab reference frame, then sum tensors within 50 km depth bins to approximate long term deformation characteristics. This builds upon previous analyses by using the up-to-date global Centroid Moment Tensor catalog, incorporating a more complete slab geometry, and focusing on the 3-D aspects of slab deformation. Results show a general consistency with Isacks and Molnar (1969), who found that most slabs can be divided into intermediate-extensional, intermediate-extensional-deep-compressional, and intermediate to deep-compressional categories. Exceptions to these three categories can be related to slab bending in the top 100 km, plate convergence that is oblique to the trench normal direction, and regions of higher focal mechanism heterogeneity. The regions of higher focal mechanism heterogeneity appear where there are along-strike changes in slab geometry and/or evidence of double-seismic zones. We find that the sense of deformation in the intermediate strain axis direction is opposite to that of the down-dip direction, in agreement with Kuge and Kawakatsu (1993). By quantitative comparison to numerical models of global mantle flow, we show that these observations are consistent with deformation of viscous slabs responding to their own negative buoyancy and an upper to lower mantle viscosity increas

V s and density structure beneath the Colorado Plateau constrained by gravity anomalies and joint inversions of receiver function and phase velocity data

The Colorado Plateau is a physiographic province in the western US with an average elevation of ∼1.9 km where, in contrast to neighboring provinces, there is little evidence of large scale tectonic deformation or magmatism. Recent availability of Earthscope/USArray seismic data allow us to better examine the crust and upper mantle structure beneath the region and test proposed explanations for the plateau's uplift and relative stability. Using phase velocities for fundamental mode Rayleigh waves and P receiver functions, we perform over 800 joint inversions for 1-D shear wave velocity VS profiles sampling the plateau and surrounding regions down to 150 km depth. We image a sharp change in crustal thickness at the western edge of the Colorado Plateau with a more gradual increase eastward moving into the Rocky Mountains. A relatively thick (≳100 km) lithosphere beneath the plateau extends into the Rocky Mountains to the north. We use empirical scaling relations to estimate densities from our VS results, and predict the associated gravity anomalies, which are inconsistent with the observed distribution of the Bouguer gravity anomalies. We somewhat reconcile the prediction and observations by assuming that lateral density variations below 50 km can be ignored and the lithospheric root is therefore neutrally buoyant. While there is some evidence for small scale convection and lithospheric removal at its edges, the shape of the lithospheric mantle anomaly is consistent with a large scale uplift of the plateau by heating since removal of the Farallon slab. We conclude that the lithospheric root is key to the long term stability of the Colorado Plateau, leading to a colder, stronger crust

Developing Students’ Energy Literacy in Higher Education

Purpose This paper aims to investigate students’ energy literacy at a UK university, and recommends ways in which it can be enhanced using a behaviour change model. Developing students’ energy literacy is a key part of the “greening” agenda, yet little is known about how students develop their ideas about energy use and energy saving at a university. Design/methodology/approach The research utilised a mixed-methods approach including an online survey (with 1,136 responses) and focus groups. Findings The research identified strengths and weaknesses in students’ energy literacy, and noted the relative influence of formal and informal curricula. The potential for aligning these curricula is highlighted through the 4Es model of enable, engage, exemplify and encourage. Research limitations/implications The research involved a single instrumental case-study site. The wider applicability of the findings should therefore be tested further in other institutions. Practical implications The research suggests ways in which universities might better support their students in making more sustainable energy-related behaviour choices, and it indicates the importance of knowledge as well as attitudes. Social implications The research may have implications for the energy-saving behaviours of individuals in the wider society. Originality/value Attempts to reduce energy use in higher education are widely seen in campus operations. This research provides an indication of the potential for enhancing energy-saving through different forms of curricula

Knowledge, agency and collective action as barriers to energy-saving behaviour

peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=cloe20Energy saving is becoming a rising priority as a response to climate change and fossil fuel depletion in recent years. However, despite energy-related behaviour change being an important part of many environmental education initiatives, “energy literacy” among citizens remains patchy in both the USA and the UK, with evidence of strong positive attitudes but less consistent knowledge. Whilst it is clear that increasing knowledge does not automatically produce behaviour changes, potential questions must be asked about the logic of focusing solely on behaviour without simultaneously exploring and enhancing understanding of energy issues. This research, undertaken at a higher education institution with a strong focus on sustainability, illustrates the potential risks of targeting behaviour change and individual action at the expense of increasing knowledge, or encouraging collaborative and democratic endeavours. Results from an online survey indicate widespread misconceptions about energy which may reduce the effectiveness of energy-saving behaviours, alongside variable levels of motivation and engagement with energy issues. Respondents report a strong belief in the efficacy of personal changes, yet uncertainty about their capacity to influence business and government alongside a persistent faith in science to provide solutions to energy issues. The paper concludes by reflecting on the challenges arising from these findings for understanding agency and effectiveness in energy relationships

Hanford waste vitrification systems risk assessment

A systematic Risk Assessment was performed to identify the technical, regulatory, and programmatic uncertainties and to quantify the risks to the Hanford Site double-shell tank waste vitrification program baseline (as defined in December 1990). Mitigating strategies to reduce the overall program risk were proposed. All major program elements were evaluated, including double-shell tank waste characterization, Tank Farms, retrieval, pretreatment, vitrification, and grouting. Computer-based techniques were used to quantify risks to proceeding with construction of the Hanford Waste Vitrification Plant on the present baseline schedule. Risks to the potential vitrification of single-shell tank wastes and cesium and strontium capsules were also assessed. 62 refs., 38 figs., 26 tabs

Mesocorticolimbic monoamine correlates of methamphetamine sensitization and motivation.

Methamphetamine (MA) is a highly addictive psychomotor stimulant, with life-time prevalence rates of abuse ranging from 5-10% world-wide. Yet, a paucity of research exists regarding MA addiction vulnerability/resiliency and neurobiological mediators of the transition to addiction that might occur upon repeated low-dose MA exposure, more characteristic of early drug use. As stimulant-elicited neuroplasticity within dopamine neurons innervating the nucleus accumbens (NAC) and prefrontal cortex (PFC) is theorized as central for addiction-related behavioral anomalies, we used a multi-disciplinary research approach in mice to examine the interactions between sub-toxic MA dosing, motivation for MA and mesocorticolimbic monoamines. Biochemical studies of C57BL/6J (B6) mice revealed short- (1 day), as well as longer-term (21 days), changes in extracellular dopamine, DAT and/or D2 receptors during withdrawal from 10, once daily, 2 mg/kg MA injections. Follow-up biochemical studies conducted in mice selectively bred for high vs. low MA drinking (respectively, MAHDR vs. MALDR mice), provided novel support for anomalies in mesocorticolimbic dopamine as a correlate of genetic vulnerability to high MA intake. Finally, neuropharmacological targeting of NAC dopamine in MA-treated B6 mice demonstrated a bi-directional regulation of MA-induced place-conditioning. These results extend extant literature for MA neurotoxicity by demonstrating that even subchronic exposure to relatively low MA doses are sufficient to elicit relatively long-lasting changes in mesocorticolimbic dopamine and that drug-induced or idiopathic anomalies in mesocorticolimbic dopamine may underpin vulnerability/resiliency to MA addiction

Carbonate determination in soils by mid-IR spectroscopy with regional and continental scale models

A Partial Least Squares (PLS) carbonate (CO3) prediction model was developed for soils throughout the contiguous United States using mid-infrared (MIR) spectroscopy. Excellent performance was achieved over an extensive geographic and chemical diversity of soils. A single model for all soil types performed very well with a root mean square error of prediction (RMSEP) of 12.6 g kg-1 and was further improved if Histosols were excluded (RMSEP 11.1 g kg-1). Exclusion of Histosols was particularly beneficial for accurate prediction of CO3 values when the national model was applied to an independent regional dataset. Little advantage was found in further narrowing the taxonomic breadth of the calibration dataset, but higher precision was obtained by running models for a restricted range of CO3. A model calibrated using only on the independent regional dataset, was unable to accurately predict CO3 content for the more chemically diverse national dataset. Ten absorbance peaks enabling CO3 prediction by mid-infrared (MIR) spectroscopy were identified and evaluated for individual and combined predictive power. A single-band model derived from an absorbance peak centered at 1796 cm-yielded the lowest RMSEP of 13.5 g kg-1 for carbonate prediction compared to other single-band models. This predictive power is attributed to the strength and sharpness of the peak, and an apparent minimal overlap with confounding co-occurring spectral features of other soil components. Drawing from the 10 identified bands, multiple combinations of 3 or 4 peaks were able to predict CO3 content as well as the full-spectrum national models. Soil CO3 is an excellent example of a soil parameter that can be predicted with great effectiveness and generality, and MIR models could replace direct laboratory measurement as a lower cost, high quality alternative

Prospectus, June 12, 1972

GOVERNOR CITES PARKLAND STUDENT FOR COMMUNITY SERVICE; Harris Moeller Selected As New Dean of Students; Charles Gerron Is Student Senate President For 1972-73 School Year; Scholarships Awarded To Parkland Students; Parkland College Personnel Receive Recognition; Teacher Aides Hold Banquet; New Registration Procedures Will Begin In Fall \u2772 Quarter; Parkland Foundation Holds First Charter Meeting; Board of Trustees Have Two Very Eventful Meetings: Results of the Meeting of April 18, 1972, Results of the Meeting of May 16, 1972; Parkland Summer Session Begins June 19; New Non-Credit Courses Slated For Summer; Graebner to Speak at Parkland Commencement; Parkland Notices: Schedule changes, Vocational Information, Summer Jobs, Summer Graduate?, For Sale-Bargain!, Summer Registration, Lost; News From William J. Scott, Attorney General - State of Illinois; Parkland Student Government Passes Viet Nam Resolution; Journalism Club; A Day In The Park Has Large Turn-Out; The Editor\u27s View: Europe This Year - A-1; Student Senate Resolution; Seed For Thought; Unique Summer-Winter Program Developed In Maine; Youth Caucus \u2772 Organized In Illinois; Portfolios to Replace Grades; Coeds Bring Fraternity Ban, Other Campus News in Brief; New Academic Calendars; Entertainment & Fine Arts, Or ( We Got Culture Too! ); Movie Review: One Day In The Life Of Ivan Denisovich; Ear Wax; Orpheus Reborn: Been around the block twice..., greece looks good..., ast i..., A babe be born..., Sweet sweets..., Away To The Mountain; WLS - Wavelength; Book Review: The Assassins (Elia Kazan); Summer Session \u2772; Summer Session; Course Offerings; Angel & Clayborn in Nationals; Hart Beathttps://spark.parkland.edu/prospectus_1972/1007/thumbnail.jp

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer‐related mortality. Despite significant advances made in the treatment of other cancers, current chemotherapies offer little survival benefit in this disease. Pancreaticoduodenectomy offers patients the possibility of a cure, but most will die of recurrent or metastatic disease. Hence, preventing metastatic disease in these patients would be of significant benefit. Using principal component analysis (PCA), we identified a LOX/hypoxia signature associated with poor patient survival in resectable patients. We found that LOX expression is upregulated in metastatic tumors from Pdx1‐Cre KrasG12D/+ Trp53R172H/+ (KPC) mice and that inhibition of LOX in these mice suppressed metastasis. Mechanistically, LOX inhibition suppressed both migration and invasion of KPC cells. LOX inhibition also synergized with gemcitabine to kill tumors and significantly prolonged tumor‐free survival in KPC mice with early‐stage tumors. This was associated with stromal alterations, including increased vasculature and decreased fibrillar collagen, and increased infiltration of macrophages and neutrophils into tumors. Therefore, LOX inhibition is able to reverse many of the features that make PDAC inherently refractory to conventional therapies and targeting LOX could improve outcome in surgically resectable disease