Journey to discover the next magic bullet

Breast cancer is currently the most common cancer among women worldwide. There are several forms of treatment, which may include hormonal therapy, targeted therapy, chemotherapy, and radiation treatments. Different treatments work better for different types of breast cancers. For example, hormone-receptor-positive breast cancers are more treatable with hormone therapies, while targeted therapies are more effective for hormone-receptor-negative breast cancers. Most of the current treatments are accompanied by harsh side effects; some of which may even lead to death of the cancer patient. Studies show that possibly focusing and performing extensive research on a patient's genetics may lead to a better form of treatment for each individual person. Between this and finding a better method of delivery of the cancer treatment drugs, which will hopefully reduce the amount of harsh side effects, this may be the next step forward in finding cures for not only breast cancers, but cancers found throughout the body

What Connects Us: A User Experience Frame Analysis Comparison of Secular and Religious Online Dating Sites

This study uses a frame analysis comparison of the website design of secular and religious online dating websites and how these design choices may shape users’ self- presentation. Literature is reviewed regarding the history of dating in secular, religious, and online contexts, self-presentation within Goffman’s The Presentation of Self in Everyday Life, and user-experience design patterns. Methodology explored a user-experience frame analysis of the initial boarding experiences navigating the presentation (homepage) and interaction features (profile-building page) on three dating sites (two secular, Tinder and Bumble, and one religious, Christian Mingle). Frames analyzed were Options, Fun, Safety, and Control based on the dating literature. After analysis, it was determined that Tinder and Bumble features could be categorized under all four frames used for analysis, whereas Christian Mingle could only be categorized under Control and not the Options, Fun, and Safety frames. Profile-building and presentation features in Tinder’s website design imply that users have freedom of self- presentation and can use the platform for a wide variety of goals, including non-dating and non- sexual friendships. In contrast, Bumble’s website design implies that female-identifying users have control and encourage users to be detail-oriented in their self-presentation, while Christian Mingle’s website design implies that one should use the platform in order to find a traditional, faith-based, heterosexual marriage, and should self-present as wanting such relationship. Both Tinder and Bumble’s website design include user-experience features that are progressive and modern, while Christian Mingle’s website design features are conservative and less experimental

Can Multi-Regional Trajectory Based Operations Reduce Workload-Related Aviation Incidents?

Multi-Regional Trajectory Based Operations (MR TBO) was developed by Florida NextGen Test Bed (FTB) along with the Federal Aviation Administration (FAA) as a method for enhancing air traffic management (ATM), both domestically and internationally. TBO offers a shift from voice-based exchanges between Air Traffic Controllers and pilots to highly automated, digital communication exchanges. The purpose of this poster is twofold. First, it explains how TBO can help improve route amendments, speed change, strategic handling of ground events, and sharing and managing multiple aircraft. Second, the poster proposes the integration of MR TBO into the National Airspace System (NAS) to decrease the number of incidents caused by high workloads of ATM. Results of this poster suggest that the operational value of adopting MR TBO extends towards the airlines, pilots, and air traffic controllers. A resulting increase of efficiency and safety will revolutionize the NAS for future generations of the aviation industry

Deep learning-based Segmentation of Rabbit fetal skull with limited and sub-optimal annotations

In this paper, we propose a deep learning-based method to segment the skeletal structures in the micro-CT images of Dutch-Belted rabbit fetuses which can assist in the assessment of drug-induced skeletal abnormalities as a required study in developmental and reproductive toxicology (DART). Our strategy leverages sub-optimal segmentation labels of 22 skull bones from 26 micro-CT volumes and maps them to 250 unlabeled volumes on which a deep CNN-based segmentation model is trained. In the experiments, our model was able to achieve an average Dice Similarity Coefficient (DSC) of 0.89 across all bones on the testing set, and 14 out of the 26 skull bones reached average DSC >0.93. Our next steps are segmenting the whole body followed by developing a model to classify abnormalities.Comment: Accepted short paper - MIDL 202

Infrared Cloud Monitoring with UCIRC2

The second generation of the Extreme Universe Space Observatory on a Super Pressure Balloon (EUSO-SPB2) is a balloon instrument that searched for ultra high energy cosmic rays (UHECRs) with energies above 1 EeV and very high energy neutrinos with energies above 1 PeV. EUSO-SPB2 consists of two telescopes: a fluorescence telescope pointed downward for the detection of UHECRs and a Cherenkov telescope toward the limb for the detection of PeV-scale showers produced by neutrino-sourced tau decay (just below the limb) and by cosmic rays (just above the limb). Clouds inside the fields of view of these telescopes--particularly that of the fluorescence telescope--reduce EUSO-SPB2's geometric aperture. As such, cloud coverage and cloud-top altitude within the field of view of the fluorescence telescope must be monitored throughout data-taking. The University of Chicago Infrared Camera (UCIRC2) monitored these clouds using two infrared cameras centered at 10 and 12 $\mu$m. By capturing images at wavelengths spanning the cloud thermal emission peak, UCIRC2 measured cloud color-temperatures and thus cloud-top altitudes. In this contribution, we provide an overview of UCIRC2, including an update on its construction and performance. We also show first results from the flight.Comment: 10 pages, 7 figures, proceedings of the 38th International Cosmic Ray Conference (ICRC 2023). arXiv admin note: substantial text overlap with arXiv:2112.09618, arXiv:1909.0266

Intentional left subclavian artery coverage during thoracic endovascular aortic repair for traumatic aortic injury

BackgroundThoracic endovascular aortic repair (TEVAR) is widely used for treatment of traumatic aortic injury (TAI). Stent graft coverage of the left subclavian artery (LSA) may be required in up to 40% of patients. We evaluated the long-term effects of intentional LSA coverage (LSAC) on symptoms and return to normal activity in TAI patients compared with a similarly treated group whose LSA was uncovered (LSAU).MethodsPatients were identified from a prospective institutional trauma registry between September 2005 and July 2012. TAI was confirmed using computed tomography angiography. The electronic medical records, angiograms, and computed tomography angiograms were reviewed in a retrospective fashion. In-person or telephone interviews were conducted using the SF-12v2 (Quality Metrics, Lincoln, RI) to assess quality of life. An additional questionnaire was used to assess specific LSA symptoms and the ability to return to normal activities. Data were analyzed by Spearman rank correlation and multiple linear and logistic regression analysis with appropriate transformations using SAS software (SAS Institute, Cary, NC).ResultsDuring the study period, 82 patients (57 men; mean age 40.5 ± 20 years, mean Injury Severity Score, 34 ± 10.0) underwent TEVAR for treatment of TAI. Among them, LSAC was used in 32 (39.5%) and LSAU in 50. A group of the LSAU patients (n = 22) served as matched controls in the analysis. We found no statistically significant difference in SF-12v2 physical health scores (ρ = −0.08; P = .62) between LSAC and LSAU patients. LSAC patients had slightly better mental health scores (ρ = 0.62; P = .037) than LSAU patients. LSAC patients did not have an increased likelihood of experiencing pain (ρ = −0.0056; P = .97), numbness (ρ = −0.12; P = .45), paresthesia (ρ = −0.11; P = .48), fatigue (ρ = −0.066; P = .69), or cramping (ρ = −0.12; P = .45). We found no difference between groups in the ability to return to activities. The mean follow-up time was 3.35 years. Six LSAC patients (19%) died during the follow-up period of unrelated causes.ConclusionsIntentional LSAC during TEVAR for TAI appears safe, without compromising mental or physical health outcomes. Furthermore, LSAC does not increase the long-term risk of upper extremity symptoms or impairment of normal activities

Perturbative QCD and factorization of coherent pion photoproduction on the deuteron

We analyze the predictions of perturbative QCD for pion photoproduction on the deuteron, gamma D -> pi^0 D, at large momentum transfer using the reduced amplitude formalism. The cluster decomposition of the deuteron wave function at small binding only allows the nuclear coherent process to proceed if each nucleon absorbs an equal fraction of the overall momentum transfer. Furthermore, each nucleon must scatter while remaining close to its mass shell. Thus the nuclear photoproduction amplitude, M_{gamma D -> pi^0 D}(u,t), factorizes as a product of three factors: (1) the nucleon photoproduction amplitude, M_{gamma N_1 -> pi^0 N_1}(u/4,t/4), at half of the overall momentum transfer, (2) a nucleon form factor, F_{N_2}(t/4), at half the overall momentum transfer, and (3) the reduced deuteron form factor, f_d(t), which according to perturbative QCD, has the same monopole falloff as a meson form factor. A comparison with the recent JLAB data for gamma D -> pi^0 D of Meekins et al. [Phys. Rev. C 60, 052201 (1999)] and the available gamma p -> pi^0 p data shows good agreement between the perturbative QCD prediction and experiment over a large range of momentum transfers and center of mass angles. The reduced amplitude prediction is consistent with the constituent counting rule, p^11_T M_{gamma D -> pi^0 D} -> F(theta_cm), at large momentum transfer. This is found to be consistent with measurements for photon lab energies E_gamma > 3 GeV at theta_cm=90 degrees and \elab > 10 GeV at 136 degrees.Comment: RevTeX 3.1, 17 pages, 6 figures; v2: incorporates minor changes as version accepted by Phys Rev

Cardiac and Renal Delayed Effects of Acute Radiation Exposure: Organ Differences in Vasculopathy, Inflammation, Senescence and Oxidative Balance

We have previously shown significant pathology in the heart and kidney of murine hematopoietic-acute radiation syndrome (H-ARS) survivors of 8.7-9.0 Gy total-body irradiation (TBI). The goal of this study was to determine temporal relationships in the development of vasculopathy and the progression of renal and cardiovascular delayed effects of acute radiation exposure (DEARE) at TBI doses less than 9 Gy and to elucidate the potential roles of senescence, inflammation and oxidative stress. Our results show significant loss of endothelial cells in coronary arteries by 4 months post-TBI (8.53 or 8.72 Gy of gamma radiation). This loss precedes renal dysfunction and interstitial fibrosis and progresses to abnormalities in the arterial media and adventitia and loss of coronary arterioles. Major differences in radiation-induced pathobiology exist between the heart and kidney in terms of vasculopathy progression and also in indices of inflammation, senescence and oxidative imbalance. The results of this work suggest a need for different medical countermeasures for multiple targets in different organs and at various times after acute radiation injury to prevent the progression of DEARE

A Potential Role for Excess Tissue Iron in Development of Cardiovascular Delayed Effects of Acute Radiation Exposure

Murine hematopoietic-acute radiation syndrome (H-ARS) survivors of total body radiation (TBI) have a significant loss of heart vessel endothelial cells, along with increased tissue iron, as early as 4 months post-TBI. The goal of the current study was to determine the possible role for excess tissue iron in the loss of coronary artery endothelial cells. Experiments utilized the H-ARS mouse model with gamma radiation exposure of 853 cGy (LD50/30) and time points from 1 to 12 weeks post-TBI. Serum iron was elevated at 1 week post-TBI, peaked at 2 weeks, and returned to non-irradiated control values by 4 weeks post-TBI. A similar trend was seen for transferrin saturation, and both results correlated inversely with red blood cell number. Perls’ Prussian Blue staining used to detect iron deposition in heart tissue sections showed myocardial iron was present as early as 2 weeks following irradiation. Pretreatment of mice with the iron chelator deferiprone decreased tissue iron, but not serum iron, at 2 weeks. Coronary artery endothelial cell density was significantly decreased as early as two weeks vs. non-irradiated controls (P<0.05), and the reduced density persisted to 12 weeks after irradiation. Deferiprone treatment of irradiated mice prevented the decrease in endothelial cell density at 2 and 4 weeks post-TBI compared to irradiated, non-treated mice (P<0.03). Taken together, the results suggest excess tissue iron contributes to endothelial cell loss early following TBI and may be a significant event impacting the development of delayed effects of acute radiation exposure