Aldosterone antagonism in heart failure

Aldosterone, a neurohormone known to affect electrolytes, has recently been implicated as playing a major role in the progression of heart failure, particularly in patients with systolic dysfunction. Major clinical trials designed to analyze clinical outcomes using an aldosterone antagonist have been done in two groups with heart failure. The first was the Randomized Aldactone Evaluation Study, which was done in symptomatic chronic advanced heart failure patients and showed that an aldosterone antagonist, spironolactone, reduced mortality significantly compared with placebo. Very few of these patients were on standard therapy with beta blockade. Another study, the Eplerenone Post myocardial infarction Heart failure Efficacy and SUrvival Study (EPHESUS), done in post-myocardial infarction patients with heart failure, demonstrated a significant reduction in mortality and hospitalizations for patients randomized to the aldosterone antagonist eplerenone. These trial results provide the background for aldosterone antagonist therapy in chronic advanced heart failure patients as well as post-myocardial infarction heart failure patients with reduced ejection

Pseudoscalar singlet physics with staggered fermions

We report on progress in measuring disconnected correlators associated with pseudoscalar flavor-singlet mesons. This will eventually allow us to compute the masses of the eta and eta' mesons. Flavor-singlet physics also presents an interesting test of the staggered fermion formulation, as disconnected correlators are sensitive to whether the same action governs both sea quarks and valence quarks. It can also help test the validity of the ``fourth-root trick'' used in unquenched lattice calculations where the number of flavors $N_f<4$.Comment: Talk presented at Lattice 2005 (Hadron spectrum and quark masses), 6 pages, 3 figure

Scalar glueball and meson spectroscopy in unquenched lattice QCD with improved staggered quarks

We present results of an exploratory study of singlet scalar states in unquenched QCD using both glueball and meson operators. Results for non-singlet non-strange scalar mesons are also presented. We use Asqtad improved staggered fermions and gauge configurations generated by the MILC collaboration at lattice spacings of .12 and .09 fm. In this formulation, the glueball mass is not significantly different from the quenched value at finite lattice spacing. Significant taste violations are present in the scalar sector. At light quark masses, decay channels complicate the mass determinations. There is some evidence that the non-strange singlet meson lies below the non-singlet meson.Comment: Lattice 2005 (hadron spectrum and quark masses), 6 pages, 4 figure

Recording brain activity can function as an implied social presence and alter neural connectivity.

People often behave differently when they know they are being watched. Here, we report the first investigation of whether such social presence effects also include brain monitoring technology, and also their impacts on the measured neural activity. We demonstrate that merely informing participants that fMRI has the potential to observe (thought-related) brain activity is sufficient to trigger changes in functional connectivity within and between relevant brain networks that have been previously associated selectively with executive and attentional control as well as self-relevant processing, social cognition, and theory of mind. These results demonstrate that an implied social presence, mediated here by recording brain activity with fMRI, can alter brain functional connectivity. These data provide a new manipulation of social attention, as well as shining light on a methodological hazard for researchers using equipment to monitor brain activity

Ultrafast electroabsorption dynamics in an InAs quantum dot saturable absorber at 1.3 mu m

The authors report a direct measurement of the absorption dynamics in an InAs p-i-n ridge waveguide quantum dot modulator. The carrier escape mechanisms are investigated via subpicosecond pump-probe measurements at room temperature, under reverse bias conditions. The optical pulses employed are degenerate in wavelength with the quantum dot ground state transition at 1.28 mu m. The absorption change recovers with characteristic times ranging from 62 ps (0 V) to similar to 700 fs (-10 V), showing a decrease of nearly two orders of magnitude. The authors show that at low applied fields, this recovery is attributed to thermionic emission while for higher applied fields, tunneling becomes the dominant mechanism. (c) 2006 American Institute of Physics.</p

A Teaching Note on the Role of Distance Learning in Case Instruction: The Course in Sustainability Management at Columbia University

This paper describes the role of online instruction in one traditional case-based course at Columbia University. We first discuss the benefits of online instruction, then detail the experience within one course, Sustainability Management, which experimented with incorporating elements of online learning into its traditional face-to-face instruction, and then analyze our experience with this innovation. The purpose of this paper is primarily descriptive: to provide a summary of the methods by which online education can be formatted within the context of case-based in-person courses to help other universities that may be planning similar courses of study

Measurement of the B Semileptonic Branching Fraction with Lepton Tags

We have used the CLEO II detector and 2.06fb^(-1) of ϒ(4S) data to measure the B-meson semileptonic branching fraction. The B→Xeν momentum spectrum was obtained over nearly the full momentum range by using charge and kinematic correlations in events with a high-momentum lepton tag and an additional electron. We find B(B→Xeν) = (10.49±0.17±0.43)%, with overall systematic uncertainties less than those of untagged single-lepton measurements. We use this result to calculate the magnitude of the Cabibbo-Kobayashi-Maskawa matrix element V_(cb) and to set an upper limit on the fraction of ϒ(4S) decays to final states other than BB̅

Search for color-suppressed B hadronic decay processes at the Υ(4S) resonance

Using 3.1fb^(-1) of data accumulated at the Υ(4S) by the CLEO-II detector, corresponding to 3.3×10^6 BB̅ pairs, we have searched for the color-suppressed B hadronic decay processes B^(0) → D^(0)(D^(*0))X^0, where X^0 is a light neutral meson π^0, ρ^0, η, η′ or ω. The D^(*0) mesons are reconstructed in D^(*0) → D^(0)π^(0) and the D^0 mesons in D^(0) → K^(-)π^(+), K^(-)π^(+)π^(0) and K^(-)π^(+)π^(+)π^(-) decay modes. No obvious signal is observed. We set 90% C.L. upper limits on these modes, varying from 1.2×10^(-4) for B^(0) → D^(0)π^(0) to 1.9×10^(-3) for B^(0) → D^(*0)η′

Two-Body B Meson Decays to η and η': Observation of B → η'K

In a sample of 6.6×10^6 produced B mesons we have observed decays B→η′K, with branching fractions B(B^+→η′K^+) = (6.5_(-1.4)^(+1.5)±0.9)×10^(-5) and B(B^0→η′K^0) = (4.7_(-2.0)^(+2.7)±0.9)×10^(-5). We have searched with comparable sensitivity for 17 related decays to final states containing an η or η′ meson accompanied by a single particle or low-lying resonance. Our upper limits for these constrain theoretical interpretations of the B→η′K signal