7,629 research outputs found
National and Regional Estimates of the Prevalence of Opiate and/or Crack Cocaine use 2008-09: A summary of key findings
<p>This report summarises the results of a follow-up study
to a three year project to estimate the prevalence of
âproblem drug useâ (defined as use of opiates and/or
crack cocaine) nationally (England only), regionally and
locally. The follow-up was carried out two years after the
final sweep of the original project, so could therefore
be considered as âsweep 5â. An overview of the national
and regional estimates are presented in this report, as are
comparisons with the estimates produced by the third
(2006-07) sweep of the study. Estimates for 2007-08 are
not available as a study was not commissioned for that
year.</p>
<p>Information about the number of people who use illicit
drugs such as heroin, other opiates or crack cocaine
is key to formulating effective policies for tackling
drug-related harm as these drugs are associated with
the highest levels of harm. It also helps inform service
provision at the local level and provides a context
in which to understand the population impact of
interventions to reduce drug-related harm.</p>
<p>Direct enumeration of those engaged in a largely covert
activity such as the use of class A drugs is difficult
and standard household survey techniques tend to
underestimate the extent of such activity. Indirect
techniques making use of various data sources offer a
more reliable way of calculating prevalence estimates for
the use of opiates and/or crack cocaine. The estimates
presented in this report are derived using two indirect
measurement techniques: the capture-recapture
method (CRC ); and the multiple indicator (MIM ) method.
These methods are described in detail in Hay et al., 2006
and Hay et al., 2007a. Methodological developments
throughout the course of the previous three sweeps are
discussed elsewhere (Hay et al., 2007b, Hay et al., 2008).
The individuals covered by this study were people aged
15 to 64 and resident in each DAT area, and known to
be using heroin, methadone, other opiate drugs or
crack cocaine.</p>
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CCH <i>N</i> = 4-3 emission from dense interstellar clouds
The authors have searched for N = 4 - 3 rotational line emission from the ethynyl radical CCH, at 349 GHz toward a number of galactic molecular clouds. They have detected emission from ten giant molecular clouds and have derived CCH column densities on the order of 1014 - 1015cm-2. They find that CCH emission arises from dense gas, n(H2) ~ 104 - 105cm-3, but not from very dense material, n(H2) > 106cm-3, nor from hot gas such as the "hot core" region in Orion
Ethics in the Oil Patch⊠Or A Review of Random Things I Read About So You Wouldn\u27t Have To
Axion-photon conversion caused by dielectric interfaces: quantum field calculation
Axion-photon conversion at dielectric interfaces, immersed in a
near-homogeneous magnetic field, is the basis for the dielectric haloscope
method to search for axion dark matter. In analogy to transition radiation,
this process is possible because the photon wave function is modified by the
dielectric layers ("Garibian wave function") and is no longer an eigenstate of
momentum. A conventional first-order perturbative calculation of the transition
probability between a quantized axion state and these distorted photon states
provides the microwave production rate. It agrees with previous results based
on solving the classical Maxwell equations for the combined system of axions
and electromagnetic fields. We argue that in general the average photon
production rate is given by our result, independently of the detailed quantum
state of the axion field. Moreover, our result provides a new perspective on
axion-photon conversion in dielectric haloscopes because the rate is based on
an overlap integral between unperturbed axion and photon wave functions, in
analogy to the usual treatment of microwave-cavity haloscopes.Comment: 15 pages, 2 figures; v2: minor changes to match published versio
Grid infrastructures for the electronics domain: requirements and early prototypes from an EPSRC pilot project
The fundamental challenges facing future electronics design is to address the decreasing â atomistic - scale of transistor devices and to understand and predict the impact and statistical variability these have on design of circuits and systems. The EPSRC pilot project âMeeting the Design Challenges of nanoCMOS Electronicsâ (nanoCMOS) which began in October 2006 has been funded to explore this space. This paper outlines the key requirements that need to be addressed for Grid technology to support the various research strands in this domain, and shows early prototypes demonstrating how these requirements are being addressed
Supporting security-oriented, collaborative nanoCMOS electronics research
Grid technologies support collaborative e-Research typified by multiple institutions and resources seamlessly shared to tackle common research problems. The rules for collaboration and resource sharing are commonly achieved through establishment and management of virtual organizations (VOs) where policies on access and usage of resources by collaborators are defined and enforced by sites involved in the collaboration. The expression and enforcement of these rules is made through access control systems where roles/privileges are defined and associated with individuals as digitally signed attribute certificates which collaborating sites then use to authorize access to resources. Key to this approach is that the roles are assigned to the right individuals in the VO; the attribute certificates are only presented to the appropriate resources in the VO; it is transparent to the end user researchers, and finally that it is manageable for resource providers and administrators in the collaboration. In this paper, we present a security model and implementation improving the overall usability and security of resources used in Grid-based e-Research collaborations through exploitation of the Internet2 Shibboleth technology. This is explored in the context of a major new security focused project at the National e-Science Centre (NeSC) at the University of Glasgow in the nanoCMOS electronics domain
Review: emerging concepts in the pathogenesis of tendinopathy
Tendinopathy is a common clinical problem and has a significant disease burden attached, not only in terms of health care costs, but also for patients directly in terms of time off work and impact upon quality of life. Controversy surrounds the pathogenesis of tendinopathy, however the recent systematic analysis of the evidence has demonstrated that many of the claims of an absence of inflammation in tendinopathy were more based around belief than robust scientific data. This review is a summary of the emerging research in this topical area, with a particular focus on the role of neuronal regulation and inflammation in tendinopathy
Towards a grid-enabled simulation framework for nano-CMOS electronics
The electronics design industry is facing major challenges as transistors continue to decrease in size. The next generation of devices will be so small that the position of individual atoms will affect their behaviour. This will cause the transistors on a chip to have highly variable characteristics, which in turn will impact circuit and system design tools. The EPSRC project "Meeting the Design Challenges of Nano-CMOS Electronics" (Nana-CMOS) has been funded to explore this area. In this paper, we describe the distributed data-management and computing framework under development within Nano-CMOS. A key aspect of this framework is the need for robust and reliable security mechanisms that support distributed electronics design groups who wish to collaborate by sharing designs, simulations, workflows, datasets and computation resources. This paper presents the system design, and an early prototype of the project which has been useful in helping us to understand the benefits of such a grid infrastructure. In particular, we also present two typical use cases: user authentication, and execution of large-scale device simulations
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