Investigation on the Electrochemistry and Cytotoxicity of Organic Nitrates and Nitroamines

Laboratory scale quantities of a series of organic nitrates and nitroamines were obtained by nitration with dinitrogen pentoxide in dichloromethane medium. Twenty seven synthesized compounds were explored by voltammetry methods and their cytotoxicity for mice splenocytes was evaluated. N.N'-dinitropiperazine, DINA and hexandiol-1,6-dinitrate were determined as some of the most toxic compounds. Several compounds having non-planar cyclic, bicyclic or cage structures (IHN, TNAD, DINGU, TEX) were found as less toxic, possibly due to poorer penetration through the cell membrane