Squamous cell carcinoma of the oral cavity: a follow up study of 85 cases and analysis of prognostic variables

We have studied clinical and morphological variables of 85 patients with squamous cell carcinoma of the oral cavity. After a follow up which varied between 2 months and 6 years, we carried out an analysis of the survival rate, and obtained significant differences (p<0.05) for the Breslow and Mantel-Cox tests in relation to the clinical stage, size and presence of lymphadenopathy. Furthermore we have carried out a predictive-prognostic statistical analysis through a multiple regression study, from which we have concluded that the size of the lesion and the number of peritumoral eosinophils were the variables with prognostic significance with respect to the survival rate of the patients. Furthermore, once the variables in relation to the incidence of relapse were analyzed, we found that the size, the presence of lymphadenopathy, the number of peritumoral eosinophils and the number of mitoses were those variables considered to be of the greatest prognostic value.Nous avons étudié les caractères cliniques et morphologiques de 85 cas de carcinome épidermoide de la cavité orale. Après un suivi de 2 mois à 6 ans, nous avons réalisé une analyse du taux de survie. Nous avons constaté des différences significatives (p< 0,05) concernant les tests de Breslow et Mantel Cox, en relation avec le stade clinique, la taille de la tumeur et l’existence d’adénopathies.Ensuite nous avons effectué une analyse statistique à l’aide d’une étude de régression multiple, qui nous a permis de conclure que la taille de la lésion et le nombre d’oesinophiles péritumoraux sont des variables dont le pronostic significatif est en rapport avec le pourcentage de survie des patients.Une fois analysées les variables en relation avec les incidences de rechute, nous avons observé que la taille de la tumeur, l’existence d’adénopathies et le nombre de mitoses sont les variables de plus grande valeur pour le pronostique

Laser-assisted guiding of electric discharges around objects

Electric breakdown in air occurs for electric fields exceeding 34 kV/cm and results in a large current surge that propagates along unpredictable trajectories. Guiding such currents across specific paths in a controllable manner could allow protection against lightning strikes and high-voltage capacitor discharges. Such capabilities can be used for delivering charge to specific targets, for electronic jamming, or for applications associated with electric welding and machining. We show that judiciously shaped laser radiation can be effectively used to manipulate the discharge along a complex path and to produce electric discharges that unfold along a predefined trajectory. Remarkably, such laser-induced arcing can even circumvent an object that completely occludes the line of sight

Assessment of and Response to Data Needs of Clinical and Translational Science Researchers and Beyond

Objective and Setting: As universities and libraries grapple with data management and “big data,” the need for data management solutions across disciplines is particularly relevant in clinical and translational science (CTS) research, which is designed to traverse disciplinary and institutional boundaries. At the University of Florida Health Science Center Library, a team of librarians undertook an assessment of the research data management needs of CTS researchers, including an online assessment and follow-up one-on-one interviews. Design and Methods: The 20-question online assessment was distributed to all investigators affiliated with UF’s Clinical and Translational Science Institute (CTSI) and 59 investigators responded. Follow-up in-depth interviews were conducted with nine faculty and staff members. Results: Results indicate that UF’s CTS researchers have diverse data management needs that are often specific to their discipline or current research project and span the data lifecycle. A common theme in responses was the need for consistent data management training, particularly for graduate students; this led to localized training within the Health Science Center and CTSI, as well as campus-wide training. Another campus-wide outcome was the creation of an action-oriented Data Management/Curation Task Force, led by the libraries and with participation from Research Computing and the Office of Research. Conclusions: Initiating conversations with affected stakeholders and campus leadership about best practices in data management and implications for institutional policy shows the library’s proactive leadership and furthers our goal to provide concrete guidance to our users in this area