Digital simulation and experimental evaluation of the CO2-H(plus) control of pulmonary ventilation

Previous models of the CO2-H(+) control of ventilation have been concerned either with the response to CO2 inhalation, or the response to perfusion of the surface of the medulla with mock cerebrospinal fluid having a high P sub CO2. Simulation of both responses with the same model has not been attempted. The purpose of the present study was two fold; first to develop such a model and, second, to obtain experimental data from human subjects for both developing this model and for evaluating this and future models

Simulation of the Respiratory Control System

This paper describes the development over the last two decades of mathematical models of the mamalian respira tory system

Exponential Peeling\u27 of Ventilatory Transients Following Inhalation of 5, 6 and 7% CO\u3csub\u3e2\u3c/sub\u3e

The \u27exponential peeling\u27 technique has been applied to minute ventilation and tidal volume transients occurring after the abrupt removal of 7,6 and 5% CO2 in inspired air. These transients, in many cases, were found to be composed of three exponential components, each contributing to the total ventilatory response and each having individual time responses. Gelfand and Lambertsen (1973) have attributed these components to the peripheral chemoreceptors as a group and to two central chemoreceptors. Statistical analysis to determine the constancy of the contribution of the three components over the the range of CO2 values studied showed that, although the values for each at the different stimulus levels were not significantly different, the great subject-to-subject variation in the data precluded a firm conclusion about the constancy of the components. Because of a number of considerations it was concluded that exponential peeling of respiratory transients following abrupt removal of CO2 inhalation is not a satisfactory way to approach the problem of the numbers, relative contributions and time responses of the various receptor groups comprising the respiratory controller