Continuous borehole optical televiewing reveals variable englacial debris concentrations at Khumbu Glacier, Nepal

Surface melting of High Mountain Asian debris-covered glaciers shapes the seasonal water supply to millions of people. This melt is strongly influenced by the spatially variable thickness of the supraglacial debris layer, which is itself partially controlled by englacial debris concentration and melt-out. Here, we present measurements of deep englacial debris concentrations from debris-covered Khumbu Glacier, Nepal, based on four borehole optical televiewer logs, each up to 150 m long. The mean borehole englacial debris content is ≤ 0.7% by volume in the glacier’s mid-to-upper ablation area, and increases to 6.4% by volume near the terminus. These concentrations are higher than those reported for other valley glaciers, although those measurements relate to discrete samples while our approach yields a continuous depth profile. The vertical distribution of englacial debris increases with depth, but is also highly variable, which will complicate predictions of future rates of surface melt and debris exhumation at such glaciers

Multi-agent-based dynamic optical subcarrier allocation for near real-time P2MP operation

We propose a multi-agent system (MAS) to manage subcarrier allocation in point-to-multipoint connectivity based on Digital Subcarrier Multiplexing. Similar performance to a centralized approach is shown, which allows for near-real time operation with increased scalability.This work has received funding from the EC through the H2020 B5G-OPEN (G.A. 101016663), the MICINN IBON (PID2020-114135RB-I00) project, and the ICREA Institution.Peer ReviewedPostprint (author's final draft

Dynamic subcarrier allocation for multipoint-to-point optical connectivity

A mathematical programming model is proposed to dynamically allocate subcarriers in the upstream direction of point-to-multipoint connections based on Digital Subcarrier Multiplexing. Numerical results show significant capital and energy cost reduction.The research leading to these results has received funding from the H2020 B5G-OPEN (G.A. 101016663), the MICINN IBON (PID2020-114135RB-I00), and the ICREA Institution.Peer ReviewedPostprint (author's final draft

The Role of Differential Ablation and Dynamic Detachment in Driving Accelerating Mass Loss From a Debris-Covered Himalayan Glacier

Sustained mass loss from Himalayan glaciers is causing supraglacial debris to expand and thicken, with the expectation that thicker debris will suppress ablation and extend glacier longevity. However, debris-covered glaciers are losing mass at similar rates to clean-ice glaciers in High Mountain Asia. This rapid mass loss is attributed to the combined effects of; (a) low or reversed mass balance gradients across debris-covered glacier tongues, (b) differential ablation processes that locally enhance ablation within the debris-covered section of the glacier, for example, at ice cliffs and supraglacial ponds, and (c) a decrease in ice flux from the accumulation area in response to climatic warming. Adding meter-scale spatial variations in supraglacial debris thickness to an ice-flow model of Khumbu Glacier, Nepal, increased mass loss by 47% relative to simulations assuming a continuous debris layer over a 31-year period (1984–2015 CE) but overestimated the reduction in ice flux. Therefore, we investigated if simulating the effects of dynamic detachment of the upper active glacier from the debris-covered tongue would give a better representation of glacier behavior, as suggested by observations of change in glacier dynamics and structure indicating that this process occurred during the last 100 years. Observed glacier change was reproduced more reliably in simulations of the active, rather than entire, glacier extent, indicating that Khumbu Glacier has passed a dynamic tipping point by dynamically detaching from the heavily debris-covered tongue that contains 20% of the former ice volume

On real-time optical subcarrier management in P2MP networks with mixed-strategy gaming

We developed a mixed-strategy gaming approach for distributed and real-time optical subscarrier management in point-to-multipoint networks, achieving traffic loss rates close to those by ILP-based centralized optimization.This work was supported in part by NSFC under Project 62201627, by the European Commission though the HORIZON SEASON (G.A. 101096120) projects, by the MICINN IBON (PID2020-114135RB-I00) project and from the ICREA institution.Peer ReviewedPostprint (author's final draft

Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma

<p>Abstract</p> <p>Background</p> <p>Interleukin-2 (IL-2) induces durable objective responses in a small cohort of patients with metastatic renal cell carcinoma (RCC) but the antigen(s) responsible for tumor rejection are not known. 5T4 is a non-secreted membrane glycoprotein expressed on clear cell and papillary RCCs. A modified vaccinia virus Ankara (MVA) encoding 5T4 was tested in combination with high-dose IL-2 to determine the safety, objective response rate and effect on humoral and cell-mediated immunity.</p> <p>Methods</p> <p>25 patients with metastatic RCC who qualified for IL-2 were eligible and received three immunizations every three weeks followed by IL-2 (600,000 IU/kg) after the second and third vaccinations. Blood was collected for analysis of humoral, effector and regulatory T cell responses.</p> <p>Results</p> <p>There were no serious vaccine-related adverse events. While no objective responses were observed, three patients (12%) were rendered disease-free after nephrectomy or resection of residual metastatic disease. Twelve patients (48%) had stable disease which was associated with improved median overall survival compared to patients with progressive disease (not reached vs. 28 months, p = 0.0261). All patients developed 5T4-specific antibody responses and 13 patients had an increase in 5T4-specific T cell responses. Although the baseline frequency of Tregs was elevated in all patients, those with stable disease showed a trend toward increased effector CD8+ T cells and a decrease in Tregs.</p> <p>Conclusion</p> <p><b>V</b>accination with MVA-5T4 did not improve objective response rates of IL-2 therapy but did result in stable disease associated with an increase in the ratio of 5T4-specific effector to regulatory T cells in selected patients.</p> <p>Trial registration number</p> <p>ISRCTN83977250</p

Development of a UK core dataset for geriatric medicine research: : a position statement and results from a Delphi consensus process

Funding AS and MW are funded by the Newcastle National Institute for Health (NIHR) Biomedical Research Centre, which also funded the initial meeting of academic clinicians in geriatric medicine during the Delphi process. The views expressed in this article are those of the authors and not necessarily those of the NIHR, the NHS, or the Department of Health. Acknowledgements The authors acknowledge the contributions of members of the UK Geriatric Medicine Core Dataset Extended Working Group.Peer reviewedPublisher PD