Association of polymorphic markers rs243865 and rs3025058 with the development of arterial hypertension

Association of polymorphic markers rs243865 and rs3025058 with the development of arterial hypertension Essential hypertension is a multifactorial polygenic disease with a highest incidence in the world. The purpose of the study was to assess the relationship between gene polymorphisms MMP2-1586S>T (rs243865) and -1612 5A/6A MMP3 (rs3025058) with the development of arterial hypertension in population of the Central Chernozem region of Russi

Linux kernel compaction through cold code swapping

There is a growing trend to use general-purpose operating systems like Linux in embedded systems. Previous research focused on using compaction and specialization techniques to adapt a general-purpose OS to the memory-constrained environment, presented by most, embedded systems. However, there is still room for improvement: it has been shown that even after application of the aforementioned techniques more than 50% of the kernel code remains unexecuted under normal system operation. We introduce a new technique that reduces the Linux kernel code memory footprint, through on-demand code loading of infrequently executed code, for systems that support virtual memory. In this paper, we describe our general approach, and we study code placement algorithms to minimize the performance impact of the code loading. A code, size reduction of 68% is achieved, with a 2.2% execution speedup of the system-mode execution time, for a case study based on the MediaBench II benchmark suite

Associations of cytokines genetic polymorphisms with hypertension progress

The article presents results of comparative analysis of cytokines genes polymorphous variants occurrence among hypertension patients with burdened familial history regarding this disease and in a control grou

Electrostatic Charge Polarity Effect on Respiratory Deposition in the Glass Bead Tracheobronchial Airways Model

The effects of unipolar and bipolar electrostatic charges on the deposition efficiency of therapeutic aerosols in the physical model of human tracheobronchial (TB) airways have been investigated. Respirable size aerosol particles were generated by a commonly prescribed and commercially available nebulizer and charged by a corona charger and then their size and charge distributions were characterized by an Electronic Single ParticleAerodynamic Relaxation Time analyzer to study the drug aerosol particles\u27 deposition pattern. The experiments were performed with a glass bead tracheobronchial model (GBTBM) (physical model) which was designed and developed based upon widely used and adopted dichotomous lung morphometric data presented in the Ewald R. Weibel model. The model was validated with the respiratory deposition data predicted by the International Commission on Radiological Protection and the United States Pharmacopeia (USP) approved Andersen Cascade Impactor (ACI). Unipolarly and bipolarly charged particles were characterized for two configurations: a) without TB model in place and b) with TB model in place. Findings showed that the deposition of unipolarly charged particles was about 3 times of the bipolarly charged particles. It was also found that bioengineered therapeutic aerosols with good combinations ofaerodynamic size and electrostatic charge are good candidates for the administration of respiratory medicinal drugs

Electrostatic Charge Polarity Effect on Respiratory Deposition in the Glass Bead Tracheobronchial Airways Model

The effects of unipolar and bipolar electrostatic charges on the deposition efficiency of therapeutic aerosols in the physical model of human tracheobronchial (TB) airways have been investigated. Respirable size aerosol particles were generated by a commonly prescribed and commercially available nebulizer and charged by a corona charger and then their size and charge distributions were characterized by an Electronic Single Particle Aerodynamic Relaxation Time analyzer to study the drug aerosol particles\u27 deposition pattern. The experiments were performed with a glass bead tracheobronchial model (GBTBM) (physical model) which was designed and developed based upon widely used and adopted dichotomous lung morphometric data presented in the Ewald R. Weibel model. The model was validated with the respiratory deposition data predicted by the International Commission on Radiological Protection and the United States Pharmacopeia (USP) approved Andersen Cascade Impactor (ACI). Unipolarly and bipolarly charged particles were characterized for two configurations: a) without TB model in place and b) with TB model in place. Findings showed that the deposition of unipolarly charged particles was about 3 times of the bipolarly charged particles. It was also found that bioengineered therapeutic aerosols with good combinations of aerodynamic size and electrostatic charge are good candidates for the administration of respiratory medicinal drugs

Effect of treatment with enrofloxacin and Lactobacillus probiotics on ABCB1, ABCC2 and ABCG2 mRNA expression in poultry

Poultry feed is often supplemented by Lactobacillus probiotics which may alter drug bioavailability by affecting the expression of intestinal ATP-binding cassette (ABC) efflux transporters. Therefore the effect of probiotics, administered alone or in combination with enrofloxacin, on the expression of ABCB1, ABCC2 and ABCG2 mRNAs in chickens was evaluated. Day-old Ross chicks (n=24) were divided in four equal groups. Control group was not treated. The second group received feed with addition of probiotics Lactobacillus brevis, L. plantarum and L. bulgaricus 5 days after hatching, for 15 days. The third group received probiotics as described above and enrofloxacin at the age of 15 days (10 mg/kg, via drinking water for 5 days). The last group received enrofloxacin at age of 15 days (10 mg/kg, via drinking water for 5 days). Expression of ABC transporters in liver, duodenum and jejunum was determined by qRT-PCR. Down-regulation of ABCG2 mRNA in the liver (P<0.05), its up-regulation in the duodenum (P<0.05) and increased ABCB1 mRNA levels in the jejunum (P<0.05) can be attributed to enrofloxacin treatment. Decrease in ABCC2 mRNA expression in the duodenum can be associated with enrofloxacin administration. The observed changes were related to enrofloxacin administration and to lesser extent to Lactobacillus supplementation

Investigation of melt-grown dilute GaAsN and GaInAsN nanostructures for photovoltaics

AbstractThe present work demonstrates the possibility to use liquid phase epitaxy to incorporate nitrogen in epitaxial GaAsN/GaAs and GaInAsN/GaAs heterostructures, including nanoscaled ones. The structures are grown from Ga - and GaIn - melts containing polycrystalline GaN as a nitrogen source. The red shift of the absorption spectra corresponds to nitrogen content in the epitaxial layers near or less than 0.2 at %. Photoluminescence spectra of dilute nitride GaAsN and GaInAsN show emission from localized nitrogen states - N-nanoclusters of more than two N atoms. These studies show that the melt grown dilute GaAsN and GaInAsN nanostructures can be used for solar cells with extended long wavelength edge