11 research outputs found
Surface supported bilayer platform for studies of lateral association of proteins in membranes (Mini Review)
A simple “proximity” correction for Förster resonance energy transfer efficiency determination in membranes using lifetime measurements
Sa1058 Quality of Colonoscopy in Russia: Report of the Quacol (Quality of Colonoscopy) Study
Polar residues in transmembrane helices can decrease electrophoretic mobility in polyacrylamide gels without causing helix dimerization
Energetics of ErbB1 Transmembrane Domain Dimerization in Lipid Bilayers
One of the most extensively studied receptor tyrosine kinases is EGFR/ErbB1. Although our knowledge of the role of the extracellular domains and ligands in ErbB1 activation has increased dramatically based on solved domain structures, the exact mechanism of signal transduction across the membrane remains unknown. The transmembrane domains are expected to play an important role in the dimerization process, but the contribution of ErbB1 TM domain to dimer stability is not known, with published results contradicting one another. We address this controversy by showing that ErbB1 TM domain dimerizes in lipid bilayers and by calculating its contribution to stability as −2.5 kcal/mol. The stability calculations use two different methods based on Förster resonance energy transfer, which give the same result. The ErbB1 TM domain contribution to stability exceeds the change in receptor tyrosine kinases dimerization propensities that can convert normal signaling processes into pathogenic processes, and is thus likely important for biological function
Transmembrane Helix Heterodimerization in Lipid Bilayers: Probing the Energetics behind Autosomal Dominant Growth Disorders
Occultation results by ACS TIRVIM at ExoMars TGO: aerosols and gases
International audienceACS is a set of three spectrometers (NIR, MIR, and TIRVIM observing the Mars atmosphere in solar occultations, nadir and limb geometry. It was built by Research Institute (IKI) in Moscow (Russia