52 research outputs found
Detecting synchronization of self-sustained oscillators by external driving with varying frequency
We propose a method for detecting the presence of synchronization of
self-sustained oscillator by external driving with linearly varying frequency.
The method is based on a continuous wavelet transform of the signals of
self-sustained oscillator and external force and allows one to distinguish the
case of true synchronization from the case of spurious synchronization caused
by linear mixing of the signals. We apply the method to driven van der Pol
oscillator and to experimental data of human heart rate variability and
respiration.Comment: 9 pages, 7 figure
Detection of synchronization from univariate data using wavelet transform
A method is proposed for detecting from univariate data the presence of
synchronization of a self-sustained oscillator by external driving with varying
frequency. The method is based on the analysis of difference between the
oscillator instantaneous phases calculated using continuous wavelet transform
at time moments shifted by a certain constant value relative to each other. We
apply our method to a driven asymmetric van der Pol oscillator, experimental
data from a driven electronic oscillator with delayed feedback and human
heartbeat time series. In the latest case, the analysis of the heart rate
variability data reveals synchronous regimes between the respiration and slow
oscillations in blood pressure.Comment: 10 pages, 9 figure
Simulating Dynamics of Circulation in the Awake State and Different Stages of Sleep Using Non-autonomous Mathematical Model With Time Delay
We propose a mathematical model of the human cardiovascular system. The model allows one to simulate the main heart rate, its variability under the influence of the autonomic nervous system, breathing process, and oscillations of blood pressure. For the first time, the model takes into account the activity of the cerebral cortex structures that modulate the autonomic control loops of blood circulation in the awake state and in various stages of sleep. The adequacy of the model is demonstrated by comparing its time series with experimental records of healthy subjects in the SIESTA database. The proposed model can become a useful tool for studying the characteristics of the cardiovascular system dynamics during sleep
Gravitational Wave Astronomy: in Anticipation of First Sources to be Detected
The first generation of long-baseline laser interferometric detectors of
gravitational waves will start collecting data in 2001-2003. We carefully
analyse their planned performance and compare it with the expected strengths of
astrophysical sources. The scientific importance of the anticipated discovery
of various gravitatinal wave signals and the reliability of theoretical
predictions are taken into account in our analysis. We try to be conservative
both in evaluating the theoretical uncertainties about a source and the
prospects of its detection. After having considered many possible sources, we
place our emphasis on (1) inspiraling binaries consisting of stellar mass black
holes and (2) relic gravitational waves. We draw the conclusion that
inspiraling binary black holes are likely to be detected first by the initial
ground-based interferometers. We estimate that the initial interferometers will
see 2-3 events per year from black hole binaries with component masses
10-15M_\odot, with a signal-to-noise ratio of around 2-3, in each of a network
of detectors consisting of GEO, VIRGO and the two LIGOs. It appears that other
possible sources, including coalescing neutron stars, are unlikely to be
detected by the initial instruments. We also argue that relic gravitational
waves may be discovered by the space-based interferometers in the frequency
interval 2x10^{-3}-10^{-2} Hz, at the signal-to-noise ratio level around 3.Comment: latex, 100 pages, including 20 postscript figures. Small typos
corrected, references adde
A Cryogenic Silicon Interferometer for Gravitational-wave Detection
The detection of gravitational waves from compact binary mergers by LIGO has opened the era of gravitational wave astronomy, revealing a previously hidden side of the cosmos. To maximize the reach of the existing LIGO observatory facilities, we have designed a new instrument able to detect gravitational waves at distances 5 times further away than possible with Advanced LIGO, or at greater than 100 times the event rate. Observations with this new instrument will make possible dramatic steps toward understanding the physics of the nearby Universe, as well as observing the Universe out to cosmological distances by the detection of binary black hole coalescences. This article presents the instrument design and a quantitative analysis of the anticipated noise floor
A Cryogenic Silicon Interferometer for Gravitational-wave Detection
The detection of gravitational waves from compact binary mergers by LIGO has
opened the era of gravitational wave astronomy, revealing a previously hidden
side of the cosmos. To maximize the reach of the existing LIGO observatory
facilities, we have designed a new instrument that will have 5 times the range
of Advanced LIGO, or greater than 100 times the event rate. Observations with
this new instrument will make possible dramatic steps toward understanding the
physics of the nearby universe, as well as observing the universe out to
cosmological distances by the detection of binary black hole coalescences. This
article presents the instrument design and a quantitative analysis of the
anticipated noise floor
Novel High Molecular Weight Aromatic Fluorinated Polymers from One-Pot, Metal-Free Step Polymerizations
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTICâHF: baseline characteristics and comparison with contemporary clinical trials
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTICâHF) trial. Here we describe the baseline characteristics of participants in GALACTICâHF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA)ââ„âII, EF â€35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokineticâguided dosing: 25, 37.5 or 50âmg bid). 8256 patients [male (79%), nonâwhite (22%), mean age 65âyears] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NTâproBNP 1971âpg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTICâHF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressureâ<â100âmmHg (n = 1127), estimated glomerular filtration rate <â30âmL/min/1.73 m2 (n = 528), and treated with sacubitrilâvalsartan at baseline (n = 1594).
Conclusions:
GALACTICâHF enrolled a wellâtreated, highârisk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
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