Multiple rectal carcinoids with diffuse ganglioneuromatosis

BACKGROUND: Rectal carcinoids comprise only about 1% of all anorectal neoplasms. In addition, ganglioneuroma of the gastrointestinal tract is a rare tumor composed ganglion cells, nerve fibers, and supporting cells. Multiple carcinoid tumors with diffuse ganglioneuromatosis limited to the rectum are quite unusual. CASE PRESENTATION: A 69-year-old man was referred to us because of about 100 small submucosal rectal tumors. He underwent abdominoperineal resection. Pathology revealed carcinoid tumors for about 30 submucosal nodules and diffuse ganglioneuromotosis. To date (6 months later) he remains well with no recurrence. CONCLUSION: Although the optimal treatment for the multiple rectal carcinoids remains to be clearly established, it is believed that not all patients with multiple rectal carcinoids (measuring less than 1 cm in diameter) need to have a radical operation. However, the treatment plan for each case should be individualized and a careful follow-up is mandatory

Bridging the great divide? Making sense of the human rights-CSR relationship in UK multinational companies

Human rights (HR) and corporate social responsibility (CSR) are both fields of knowledge and research that have been shaped by, and examine, the role of multi-national enterprises in society. Whilst scholars have highlighted the overlapping nature of CSR and HR, our understanding of this relationship within business practice remains vague and under-researched. To explore the interface between CSR and HR, this paper presents empirical data from a qualitative study involving 22 international businesses based in the UK. Through an analysis based on sensemaking, the paper examines how and where CSR and HR overlap, contrast and shape one another, and the role that companies’ international operations has on this relationship. The findings reveal a complex and multi-layered relationship between the two, and concludes that in contrast to management theory, companies have bridged the ‘great divide’ in varying degrees most notably in their implementation strategies

A Study on Child-Rearing Anxiety : In case of fathers

1.育児不安研究の問題,2.育児不安の規定と類型,(1)育児不安の規定,(2)育児不安の類型,3.研究の目的と分析の枠組(以上,住田),4.調査の概要,5.調査結果の分析,(1)父親の育児参加と育児不安,(2)夫婦関係と父親の育児不安,(3)母親の育児不安と父親の育児不安の関係,6.まとめ(以上,藤井)The aim of this research is to clarify the actual condition of fathers\u27 child-rearing anxiety. Some researches have dealt with mothers\u27 child-rearing anxiety, because the idea was widely accepted that child-rearing is a role of mothers. Increasing participation of mothers in public affairs, fathers are expected to participate in the housekeeping and child-rearing, and actually they do. Then we made an investigation on child-rearing anxiety into 570 pairs of kindergarten pupils\u27 parents. At this time, we classified child-rearing anxiety into three types. One is the feeling of discomfort which is brought by child-rearing, one is the anxiety about child\u27s growth and development, and another is the anxiety about one\u27s own ability of child-rearing. The principle findings are as follows. 1) The fathers who participate in child-rearing tend to feel anxiety about child\u27s growth and development. They observe their children closely when they take care of them and would become anxious about their growth and development. But they have the discomfort feeling less than the fathers who leave child-rearing to their wives. The experiences of taking care of their children would lead to deep understanding on them and they reduce their discomfort feeling brought by child-rearing. 2) The fathers who are not satisfied with the way of child-rearing of their wives have the discomfort feeling more than the fathers who are satisfied with it. Fathers\u27 dissatisfaction with the way of child-rearing of their wives means their children\u27s are ill-mannered. Fathers would feel discomfort when they are with their ill-mannered children. 3) Communication between father and mother influences the father\u27s feeling of discomfort brought by child-rearing. The less communication brings the discomfort feeling and the more communication reduces it. But in case of fathers who think they communicate enough with their wives and their wives don\u27t think so, their feelings of discomfort are higher than that of fathers who think their communication is not enough. 4) The child-rearing anxiety of mothers influences that of their husbands. For example, the higher the mothers\u27 discomfort feeling, the higher their husbands\u27. The fathers also feel anxious about their children\u27s growth and development and about their own ability of child-rearing, if their wives have the anxiety about them. And when mothers have frustration through their child-rearing, their husbands feel anxious about their own ability of child-rearing

Stereoselective Synthesis of <i>Z</i>‑α,β-Unsaturated Sulfones Using Peterson Reagents

New Peterson reagents were prepared by introducing alkyloxy groups on the silicon atom in order to fix the conformation of the sulfone anion. The reagents <b>1d</b> and <b>1e</b> reacted with a variety of aldehydes after the treatment with Li-base to give <i>Z</i>-α,β-unsaturated sulfones with up to >99:1 selectivity in good to excellent yields. For the reaction with aliphatic aldehydes, CPME (cyclopentyl methyl ether) is the choice of solvent, while DME (1,2-dimethoxyethane) gave higher selectivity for the reaction with aromatic aldehydes

育児不安に関する研究 : 父親の場合

The aim of this research is to clarify the actual condition of fathers' child-rearing anxiety. Some researches have dealt with mothers' child-rearing anxiety, because the idea was widely accepted that child-rearing is a role of mothers. Increasing participation of mothers in public affairs, fathers are expected to participate in the housekeeping and child-rearing, and actually they do. Then we made an investigation on child-rearing anxiety into 570 pairs of kindergarten pupils' parents. At this time, we classified child-rearing anxiety into three types. One is the feeling of discomfort which is brought by child-rearing, one is the anxiety about child's growth and development, and another is the anxiety about one's own ability of child-rearing. The principle findings are as follows. 1) The fathers who participate in child-rearing tend to feel anxiety about child's growth and development. They observe their children closely when they take care of them and would become anxious about their growth and development. But they have the discomfort feeling less than the fathers who leave child-rearing to their wives. The experiences of taking care of their children would lead to deep understanding on them and they reduce their discomfort feeling brought by child-rearing. 2) The fathers who are not satisfied with the way of child-rearing of their wives have the discomfort feeling more than the fathers who are satisfied with it. Fathers' dissatisfaction with the way of child-rearing of their wives means their children's are ill-mannered. Fathers would feel discomfort when they are with their ill-mannered children. 3) Communication between father and mother influences the father's feeling of discomfort brought by child-rearing. The less communication brings the discomfort feeling and the more communication reduces it. But in case of fathers who think they communicate enough with their wives and their wives don't think so, their feelings of discomfort are higher than that of fathers who think their communication is not enough. 4) The child-rearing anxiety of mothers influences that of their husbands. For example, the higher the mothers' discomfort feeling, the higher their husbands'. The fathers also feel anxious about their children's growth and development and about their own ability of child-rearing, if their wives have the anxiety about them. And when mothers have frustration through their child-rearing, their husbands feel anxious about their own ability of child-rearing.1.育児不安研究の問題,2.育児不安の規定と類型,(1)育児不安の規定,(2)育児不安の類型,3.研究の目的と分析の枠組(以上,住田),4.調査の概要,5.調査結果の分析,(1)父親の育児参加と育児不安,(2)夫婦関係と父親の育児不安,(3)母親の育児不安と父親の育児不安の関係,6.まとめ(以上,藤井

Intraventricular cerebrospinal fluid temperature analysis using MR diffusion-weighted imaging thermometry in Parkinson's disease patients, multiple system atrophy patients, and healthy subjects

[Purpose]We examined the temperature of the intraventricular cerebrospinal fluid (Tv) in patients with Parkinson's disease (PD) and those with multiple system atrophy (MSA) in comparison with healthy subjects, and we examined normal changes in this temperature with aging. [Methods]Tv was estimated by magnetic resonance (MR) diffusion-weighted imaging (DWI) thermometry in 36 PD patients (19 males, 17 females), 34 MSA patients (17 males, 17 females), 64 age-matched controls (27 men, 37 women), and 114 all-age adult controls (47 men, 67 women; 28–89 years old). The volume of lateral ventricles was also estimated using FreeSurfer in all subjects. Tv and ventricular volume data were compared among the PD and MSA patients and age-matched controls. We also evaluated the relationship between Tv and age in the 114 all-age controls, controlling for ventricular volume. Men and women were analyzed separately. [Results]The male PD and MSA patients had significantly higher Tv values compared to the male controls, with no significant difference in ventricular volume among them. There was no significant difference in Tv between the female patients and controls. In the all-age male controls, there was a significant negative correlation between Tv and age controlling for ventricular volume, and this was not observed in the women. [Conclusion]DWI thermometry is a useful and easy method for demonstrating an altered intracranial environment in male patients and healthy controls, but not in females. DWI thermometry can thus be used to help to explore the pathophysiology of Parkinsonian syndromes and to differentiate individuals affected by neurodegenerative disease with autonomic dysfunction from those without it

Human induced pluripotent stem cell line (ONHi001-A) generated from a patient with infantile neuroaxonal dystrophy having PLA2G6 c.517C > T (p.Q173X) and c.1634A > G (p.K545R) compound heterozygous mutations

Infantile neuroaxonal dystrophy (INAD) is a rare neurodegenerative disease caused mainly by homozygous or compound heterozygous mutations in the PLA2G6 gene. We generated a human induced pluripotent stem cell (hiPSC) line (ONHi001-A) using fibroblasts derived from a patient with INAD. The patient exhibited c.517C > T (p.Q173X) and c.1634A > G (p.K545R) compound heterozygous mutations in the PLA2G6 gene. This hiPSC line may be useful for studying the pathogenic mechanism underlying INAD