A relationship between US healthcare worker smallpox vaccination rates in 2003 and presidential election results in 2004

A statistical relationship exists between state per capita smallpox vaccination rates of healthcare workers in 2003 and state presidential election results in 2004. The potential implications of political influence on national biosecurity decision making are discussed

Experimental flight test vibration measurements and nondestructive inspection on a USCG HC-130H aircraft

This paper presents results of experimental flight test vibration measurements and structural inspections performed by the Federal Aviation Administration`s Airworthiness Assurance NDI Validation Center (AANC) at Sandia National Laboratories and the US Coast Guard Aircraft Repair and Supply Center (ARSC). Structural and aerodynamic changes induced by mounting a Forward Looking Infrared (FLIR) system on a USCG HC-130H aircraft are described. The FLIR adversely affected the air flow characteristics and structural vibration on the external skin of the aircraft`s right main wheel well fairing. Upon initial discovery of skin cracking and visual observation of skin vibration in flight by the FLIR, a baseline flight without the FLIR was conducted and compared to other measurements with the FLIR installed. Nondestructive inspection procedures were developed to detect cracks in the skin and supporting structural elements and document the initial structural condition of the aircraft. Inspection results and flight test vibration data revealed that the FLIR created higher than expected flight loading and was the possible source of the skin cracking. The Coast Guard performed significant structural repair and enhancement on this aircraft, and additional in-flight vibration measurements were collected on the strengthened area both with and without the FLIR installed. After three months of further operational FLIR usage, the new aircraft skin with the enhanced structural modification was reinspected and found to be free of flaws. Additional US Coast Guard HC-130H aircraft are now being similarly modified to accommodate this FLIR system. Measurements of in-flight vibration levels with and without the FLIR installed, and both before and after the structural enhancement and repair were conducted on the skin and supporting structure in the aircraft`s right main wheel fairing. Inspection results and techniques developed to verify the aircraft`s structural integrity are discussed

Crack detection on HU-25 Guardian aircraft

An ultrasonic inspection method was developed at FAA`s Airworthiness Assurance NDI Validation Center (AANC) to easily and rapidly detect hidden fatigue cracks in the copilot vertical windshield post on USCG (Coast Guard) HU-25 `Guardian` aircraft. The inspection procedure locates hidden cracks as small as 3.2 mm emanating from internal fastener holes and determines their length. A test procedure was developed and a baseline assessment of the USCG fleet conducted. Inspection results on 41 aircraft revealed good correlation with results made during subsequent structural disassembly and visual inspection of selected aircraft

The Florey Adelaide Male Ageing Study (FAMAS): Design, procedures & participants

<p>Abstract</p> <p>Background</p> <p>The Florey Adelaide Male Ageing Study (FAMAS) examines the reproductive, physical and psychological health, and health service utilisation of the ageing male in Australia. We describe the rationale for the study, the methods used participant response rates, representativeness and attrition to date.</p> <p>Methods</p> <p>FAMAS is a longitudinal study involving approximately 1200 randomly selected men, aged 35–80 years and living in the north – west regions of Adelaide. Respondents were excluded at screening if they were considered incapable of participating because of immobility, language, or an inability to undertake the study procedures. Following a telephone call to randomly selected households, eligible participants were invited to attend a baseline clinic measuring a variety of biomedical and socio-demographic factors. Beginning in 2002, these clinics are scheduled to reoccur every five years. Follow-up questionnaires are completed annually. Participants are also invited to participate in sub-studies with selected collaborators.</p> <p>Results</p> <p>Of those eligible to participate, 45.1% ultimately attended a clinic. Non-responders were more likely to live alone, be current smokers, have a higheevalence of self-reported diabetes and stroke, and lower levels of hypercholesterolemia. Comparisons with the Census 2001 data showed that participants matched the population for most key demographics, although younger groups and never married men were under-represented and elderly participants were over-represented. To date, there has been an annual loss to follow-up of just over 1%.</p> <p>Conclusion</p> <p>FAMAS allows a detailed investigation into the effects of bio-psychosocial and behavioural factors on the health and ageing of a largely representative group of Australian men.</p

Reconstruction versus conservative treatment after rupture of the anterior cruciate ligament: cost effectiveness analysis

BACKGROUND: The decision whether to treat conservatively or reconstruct surgically a torn anterior cruciate ligament (ACL) is an ongoing subject of debate. The high prevalence and associated public health burden of torn ACL has led to continuous efforts to determine the best therapeutic approach. A critical evaluation of benefits and expenditures of both treatment options as in a cost effectiveness analysis seems well-suited to provide valuable information for treating physicians and healthcare policymakers. METHODS: A literature review identified four of 7410 searched articles providing sufficient outcome probabilities for the two treatment options for modeling. A transformation key based on the expert opinions of 25 orthopedic surgeons was used to derive utilities from available evidence. The cost data for both treatment strategies were based on average figures compiled by Orthopaedic University Hospital Balgrist and reinforced by Swiss national statistics. A decision tree was constructed to derive the cost-effectiveness of each strategy, which was then tested for robustness using Monte Carlo simulation. RESULTS: Decision tree analysis revealed a cost effectiveness of 16,038 USD/0.78 QALY for ACL reconstruction and 15,466 USD/0.66 QALY for conservative treatment, implying an incremental cost effectiveness of 4,890 USD/QALY for ACL reconstruction. Sensitivity analysis of utilities did not change the trend. CONCLUSION: ACL reconstruction for reestablishment of knee stability seems cost effective in the Swiss setting based on currently available evidence. This, however, should be reinforced with randomized controlled trials comparing the two treatment strategies

Osteointegration of soft tissue grafts within the bone tunnels in anterior cruciate ligament reconstruction can be enhanced

Anterior cruciate ligament reconstruction with a soft tissue autograft (hamstring autograft) has grown in popularity in the last 10 years. However, the issues of a relatively long healing time and an inferior histological healing result in terms of Sharpey-like fibers connection in soft tissue grafts are still unsolved. To obtain a promising outcome in the long run, prompt osteointegration of the tendon graft within the bone tunnel is essential. In recent decades, numerous methods have been reported to enhance osteointegration of soft tissue graft in the bone tunnel. In this article, we review the current literature in this research area, mainly focusing on strategies applied to the local bone tunnel environment. Biological strategies such as stem cell and gene transfer technology, as well as the local application of specific growth factors have been reported to yield exciting results. The use of biological bone substitute and physical stimulation also obtained promising results. Artificially engineered tissue has promise as a solution to the problem of donor site morbidity. Despite these encouraging results, the current available evidence is still experimental. Further clinical studies in terms of randomized control trial in the future should be conducted to extrapolate these basic science study findings into clinical practice. © 2009 Springer-Verlag.postprin