Un procedeu original de construcţie şi utilizare a lamboului nazogenian

Introduction. The classical naso-labial fl ap used for the reconstruction of tongue and oral floor presents multiple drawbacks. As an alternative to the classical one we present an original procedure of preparation of the naso-labial fl ap evaluated after seven years of use. Material and Method. The procedure we used was fi rst applied in the Oral and Maxillofacial Surgery Clinic in Cluj-Napoca seven years ago on patients suffering from tongue and/or oral floor malignancies in order to reconstruct these anatomical areas after the excision of the tumours in oncological safe limits. Most of its preparation procedure was made according to the classical method with some modifi cations in the preparation of its base. In order to enhance its covering area and functional availability and to eliminate some drawbacks, the route to the receptor area was changed. The submandibular course was used instead of the transbuccal one. Results. In all 21 patients who underwent surgery, a considerable enhancement of fl ap covering availability was obtained. It was able to cover defects ranging from the posterior limits of the tongue and oral fl oor to the tongue tip even beyond the midline. Unlike in the classical method there was no need to perform tooth extractions in dentulous patients. It is a one step procedure. Thus, the second step of the classical method was eliminated. Conclusions. The naso-labial fl ap with submandibular course offers covering and functional availability superior than the classical one with transbuccal route. It preserves and reconstructs the perimandibular anatomical sites. It also shortens the surgical treatment period of tongue and oral floor malignancies

The Presence of Periodontitis in Patients with Von Willebrand Disease: A Systematic Review

The aim of this systematic review and meta-analysis was to analyze the available evidence on the assessment of periodontal disease in patients with von Willebrand disease (VWD). An electronic search in three databases (PubMed, Web of Science, and Scopus) was conducted by three independent reviewers to identify cross-sectional, cohort, and clinical trial studies. Studies considered eligible for this review were evaluated according to the quality and risk assessment tool proposed by the CLARITY Group at McMaster University. In order to analyze the possible correlation of VWD patients and periodontitis and their susceptibility to bleeding during the periodontal screening phase, periodontal parameters evaluated were probing pocket depth (PPD), bleeding on probing (BOP), gingival bleeding index (GBI), and periodontal inflamed surface area (PISA). After a screening of 562 articles, three articles were selected for the qualitative analysis. Within the limitation of our review, VWD patients are not more susceptible to periodontitis as compared with non-VWD patients. Nevertheless, bleeding on probing and gingival index needs to be carefully taken into consideration during periodontal screening of VWD due to the possible presence of false positives

The Prevalence Of Hypodontia In Children With Cleft And Nonrelated Controls

The aim of this study was to compare the occurrence of hypodontia, dental age, and asymmetric dental development in children with cleft with a non- sibling control group. The study sample consisted of 30 children with cleft (aged 7.2 to 17.1 years) and 60 controls without cleft (aged between 7 and 18.8 years). Hypodontia, dental age, and asymmetric dental development were assessed on panoramic radiographs of the children with cleft and the control children without cleft. The cleft (p.001) group showed a significantly higher frequency of hypodontia and a significantly higher occurrence (cleft p.01) of asymmetric dental development, compared with the control group. Only a small, but insignificant delay in dental development could be found in the cleft group. The cleft subjects showed a significantly higher occurrence of hypodontia and asymmetric dental development than the non-cleft control group. This may suggest a genetic component for the occurrence of hypodontia and asymmetric dental development

THE PREVALENCE OF HYPODONTIA IN CHILDREN WITH CLEFT AND NONRELATED CONTROLS

The aim of this study was to compare the occurrence of hypodontia, dental age, and asymmetric dental development in children with cleft with a nonsibling control group. The study sample consisted of 30 children with cleft (aged 7.2 to 17.1 years) and 60 controls without cleft (aged between 7 and 18.8 years). Hypodontia, dental age, and asymmetric dental development were assessed on panoramic radiographs of the children with cleft and the control children without cleft. The cleft (p.001) group showed a significantly higher frequency of hypodontia and a significantly higher occurrence (cleft p.01) of asymmetric dental development, compared with the control group. Only a small, but insignificant delay in dental development could be found in the cleft group. The cleft subjects showed a significantly higher occurrence of hypodontia and asymmetric dental development than the non-cleft control group. This may suggest a genetic component for the occurrence of hypodontia and asymmetric dental development

ORAL INTERDISCIPLINARY REHABILITATION IN THE CONTEXT OF NUMERICAL DEFICIT DENTAL ABNORMALITIES

Objectives: The purpose of this study was to track the frequency of agenesis in a group of children and adolescents who underwent treatment at the Orthodontic Clinic in Cluj-Napoca between 2014 and 2017. Material and Method: We studied a group of 700 children aged 7-18 years. Classification was based on gender, clinical abnormalities, teeth, associated anomalies. Results: In our study, 4% of patients had at least one dental agenesis, the upper lateral incisors being the most frequently affected (47%). In terms of gender, the female was affected with a higher percentage (69%). Conclusions: Treatment of hypodontia is often an individualized interdisciplinary treatment, depending on the severity of the anomaly and associated general disease

Comparison of the Eggshell and the Porcine Pericardium Membranes for Guided Tissue Regeneration Applications

Guided bone regeneration is frequently used to reconstruct the alveolar bone to rehabilitate the mastication using dental implants. The purpose of this article is to research the properties of eggshell membrane (ESM) and its potential application in tissue engineering. The study focuses on the structural, mechanical, and histological characteristics of ESM extracted from Gallus domesticus eggs and to compare them to a commercially available porcine pericardium membrane (Jason® membrane, botiss biomaterials GmbH, Zossen, Germany). Thus, histology was performed on the ESM, and a comparison of the microstructure through scanning electron microscopy and atomic force microscopy (AFM) was conducted. Also, mechanical tensile strength was evaluated. Samples of ESM were prepared and treated with alcohol for fixation and disinfection. Histological analysis revealed that the ESM architecture is constituted out of loose collagen fibers. However, due to the random arrangement of collagen fibers within the membrane, it might not be an effective barrier and occlusive barrier. Comparative analyses were performed between the ESM and the AFM examinations and demonstrated differences in the surface topography and mechanical properties between the two membranes. The ESM exhibited rougher surfaces and weaker mechanical cohesion attributed to its glycoprotein content. The study concludes that while the ESM displays favorable biocompatibility and resorb ability, its non-uniform collagen arrangement limits its suitability as a guided bone regeneration membrane in the current non-crosslinked native form. Crosslinking techniques may enhance its properties for such applications. Further research is needed to explore modifications and processing methods that could leverage the ESM’s unique properties for tissue engineering purposes

The Connection between MicroRNAs and Oral Cancer Pathogenesis: Emerging Biomarkers in Oral Cancer Management

Oral cancer is a common human malignancy that still maintains an elevated mortality rate despite scientific progress. Tumorigenesis is driven by altered gene expression patterns of proto-oncogenes and tumor-suppressor genes. MicroRNAs, a class of short non-coding RNAs involved in gene regulation, seem to play important roles in oral cancer development, progression, and tumor microenvironment modulation. As properties of microRNAs render them stable in diverse liquid biopsies, together with their differential expression signature in cancer cells, these features place microRNAs at the top of promising biomarkers for diagnostic and prognostic values. In this review, we highlight eight expression levels and functions of the most relevant microRNAs involved in oral cancer development, progression, and microenvironment sustainability. Furthermore, we emphasize the potential of using these small RNA species as non-invasive biomarkers for the early detection of oral cancerous lesions. Conclusively, we highlight the perspectives and limitations of microRNAs as novel diagnostic tools, as well as therapeutic models

Raman Micro-Spectroscopy of Dental Pulp Stem Cells: An Approach to Monitor the Effects of Cone Beam Computed Tomography Low-Dose Ionizing Radiation

© 2018, © 2018 Taylor & Francis. The objective of this study was to determine the molecular and biochemical changes in dental pulp stem cells (DPSCs) due to consecutive low-dose ionizing radiation exposures using label-free Raman micro-spectroscopy (RMS). Ionizing radiation produces biological damage leading to health effects of varying severity. The effects and subsequent health implications caused by exposure to low-dose radiation, such as diagnostic exposure, remain ambiguous. We identified Raman biomarkers characteristic to low-dose cone beam computed tomography (CBCT) irradiation of the DPSCs. The biomarkers were monitored inside the cells using the relative intensity distribution of the 785 and 1734 cm −1 bands. The control cells presented a higher relative intensity of the nucleic acid specific Raman bands, whereas the irradiated cells revealed an increased intensity of the lipid-induced bands. The results obtained in this study demonstrate the capability of RMS for the detection of cell response to diagnostic radiation dose levels. This may indicate the potential of the technique for future applications such as monitoring the radiation responses in pediatric patients suffering repeated radiological exposures.status: publishe