Polyphenols in the Waste Water Produced during the Hydrodistillation of ‘Narcea Roses’ Cultivated in the Cibea River Valley (Northern Spain)

The ‘Narcea rose’ is a recently described yet ancient rose cultivar of interest to the perfume industry. Given its excellent adaptation to the conditions of the place where it was rediscovered, the possibilities of its horticultural/industrial production have been under examination for some time. The hydrodistillation process produces a red-to-brownish mixture of water and rose petals that could contain compounds that could be used in other industrial procedures. Their recovery and further utilization would reduce disposal costs and improve the sustainability of relevant industries. This work reports the quantification, by high-performance liquid chromatography (HPLC–MS) and quadrupole time of flight Q-TOF analyses, of the polyphenol content in the waste water. This waste was found to contain high concentrations of quercetin, gallic acid and ellagic acid, as well as smaller concentrations of kaempferol and its derivatives, all of which can influence plant, human and animal health.This research received no external funding

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present